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Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

Abstract：

:Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies that bind to P/Q voltage-gated calcium channels at the neuromuscular junction. Using cell-free direct peptide binding in 12 LEMS patients, we find linear B-cell epitopes that reside on the extracellular peptide linkers between the S5-S6 transmembrane peptides of Domains II and IV. A major epitope is located within the S5-S6 linker peptide of Domain IV defined by the acidic amino acid sequence EDEDSDEDE.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Parsons KT,Kwok WW

doi

10.1016/s0165-5728(02)00063-2

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

190-5

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572802000632

journal_volume

126

pub_type

杂志文章

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