Abstract:
:Carbon nantotubes (CNTs) are emerging as a new family of nanovectors for drug and gene delivery into biological systems. To evaluate potential application of this technology for brain tumor therapy, we studied uptake and toxicity of multi-walled CNTs (MWCNTs) in the GL261 murine intracranial glioma model. Within 24 h of a single intratumoral injection of labeled MWCNTs (5 microg), nearly 10-20% of total cells demonstrated CNT internalization. Most CNT uptake, however, occurred by tumor-associated macrophages (MP), which accounted for most (75%) MWCNT-positive cells. Within 24 h of injection, nearly 30% of tumor MP became MWCNT-positive. Despite a transient increase in inflammatory cell infiltration into both normal and tumor-bearing brains following MWCNT injection, no significant toxicity was noted in mice, and minor changes in tumor cytokine expression were observed. This study suggests that MWCNTs could potentially be used as a novel and non-toxic vehicle for targeting MP in brain tumors.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
VanHandel M,Alizadeh D,Zhang L,Kateb B,Bronikowski M,Manohara H,Badie Bdoi
10.1016/j.jneuroim.2008.12.006subject
Has Abstractpub_date
2009-03-31 00:00:00pages
3-9issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(08)00492-Xjournal_volume
208pub_type
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journal_title:Journal of neuroimmunology
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更新日期:2013-10-15 00:00:00
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
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更新日期:2014-03-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(95)00119-0
更新日期:1995-12-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2013.08.015
更新日期:2013-11-15 00:00:00
abstract::In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
abstract::Clinically isolated syndrome (CIS) is a first, usually recovering, episode of neurological disturbance(s) suggestive of multiple sclerosis (MS). CIS subjects might benefit from early disease-modifying drugs, provided that those at high risk of developing MS can be identified. Gene expression for dopaminergic receptors...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2016-09-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章,评审
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更新日期:1997-02-01 00:00:00
abstract::Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS ...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2005.04.012
更新日期:2005-08-01 00:00:00
abstract::Tumorigenesis requires interactions between tumor progenitors and their microenvironment. We found that low cAMP levels were sufficient for tumorigenesis in a mouse model of Neurofibromatosis-1 (NF1)-associated optic pathway glioma (OPG). We hypothesized that the distinct pattern of glioma in NF1 reflected spatiotempo...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2010-07-27 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(87)90118-4
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(82)90024-8
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journal_title:Journal of neuroimmunology
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更新日期:2016-01-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2005.09.015
更新日期:2006-02-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(90)90012-c
更新日期:1990-08-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2007.04.005
更新日期:2007-08-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2010.05.028
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:Autoreactive antibodies (ARAB) occur more frequently in patients with multiple sclerosis (MS) than in general population and the presence of these antibodies often causes uncertainty regarding the disease course, response to therapy and the diagnosis of MS. METHODS:Retrospective analyses of the ARAB, clinic...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2007.04.008
更新日期:2007-07-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2018-09-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2007.07.024
更新日期:2007-10-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with myelin basic protein (MBP) and adjuvants. Rats were treated with second daily injections of saline or cyclosporin A (CsA) from the day of inoculation. Saline-treated rats had an acute episode of disease followed by clinical r...
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pub_type: 杂志文章
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