当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Interactions between CD4+ T-cells and rat Schwann cells in vitro. 2. Cytotoxic effects of P2-specific CD4+ T-cell lines on Lewis rat Schwann cells.

Interactions between CD4+ T-cells and rat Schwann cells in vitro. 2. Cytotoxic effects of P2-specific CD4+ T-cell lines on Lewis rat Schwann cells.

Abstract：

:The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with 51Cr-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not necessary for the cytotoxic effect. The monoclonal antibody (mAb) OX6 directed against Major histocompatibility complex (MHC) class II molecules blocked cytotoxicity, indicating an essential role for MHC class II molecules in this interaction between CD4+ T-cell lines and Schwann cells.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Argall KG,Armati PJ,Pollard JD,Bonner J

doi

10.1016/0165-5728(92)90209-4

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

19-29

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165-5728(92)90209-4

journal_volume

40

pub_type

杂志文章

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