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Disruption of the beta2-integrin CD11d (alphaDbeta2) gene fails to protect against experimental autoimmune encephalomyelitis.

Abstract：

:The fourth member of the beta(2)-integrin family of adhesion molecules, CD11d (alpha(D)beta(2)), is expressed on a wide variety of immune cells, however its function in autoimmune diseases, including EAE remains unknown. We induced EAE in wild-type and CD11d(-/-) C57BL/6 mice using myelin oligodendrocyte glycoprotein (MOG(35-55)) peptide. The clinical course and histopathology of EAE were identical in both groups of mice throughout the disease course. There were no significant differences in the infiltration of leukocyte subsets into the central nervous system or in the production of cytokines from T cells isolated from the spleen or spinal cord from both groups of mice. Our data demonstrate that CD11d is not required for the development of EAE and, to date, is the only beta(2)-integrin molecule whose deletion does not result in attenuated disease.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Adams JE,Webb MS,Hu X,Staunton D,Barnum SR

doi

10.1016/j.jneuroim.2006.12.007

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

180-7

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00517-0

journal_volume

184

pub_type

杂志文章

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