Elevation of serum prostaglandin E levels following electrical stimulation of the midbrain.

abstract：:Three monoclonal antibodies reactive with human myelin basic protein have been used to develop immunoradiometric assays for this protein. Clone 1, a mouse IgG2a, is reactive with an epitope in the region 129-138. Clone 2, a mouse IgG1, is reactive with the region 119-131. Clone 12, a rat IgG, is reactive with the regi...

journal_title：Journal of neuroimmunology

authors： Groome NP,Dawkes A,Gales M,Hruby S,Alvord EC Jr

更新日期：1986-10-01 00:00:00

abstract：:The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies toward...

journal_title：Journal of neuroimmunology

authors： Krestova M,Ricny J,Bartos A

更新日期：2018-09-15 00:00:00

abstract：:In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was f...

journal_title：Journal of neuroimmunology

authors： Peelen E,Damoiseaux J,Smolders J,Knippenberg S,Menheere P,Tervaert JW,Hupperts R,Thewissen M

更新日期：2011-12-15 00:00:00

abstract：:Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the activation loop of ...

journal_title：Journal of neuroimmunology

authors： Jager LD,Dabelic R,Waiboci LW,Lau K,Haider MS,Ahmed CM,Larkin J 3rd,David S,Johnson HM

更新日期：2011-03-01 00:00:00

abstract：:Opioid-containing immunocytes migrate to inflamed sites where they release beta-endorphin which activates peripheral opioid receptors and produces analgesia. The immigration of immunocytes to sites of inflammation is mediated by adhesion molecules. In this study, the expression of L-, P-, E-selectin and platelet-endot...

journal_title：Journal of neuroimmunology

authors： Mousa SA,Machelska H,Schäfer M,Stein C

更新日期：2000-08-01 00:00:00

abstract：:Synthetic peptides of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) were screened for their ability to induce experimental allergic encephalomyelitis (EAE) in ABH (H-2A(g7)) and SJL (H-2(s)) mice. The use of overlapping 16mer...

journal_title：Journal of neuroimmunology

authors： Morris-Downes MM,McCormack K,Baker D,Sivaprasad D,Natkunarajah J,Amor S

更新日期：2002-01-01 00:00:00

abstract：:A new technique for a conglutinin ELISA using a microtiter plate has been developed for measuring circulating immune complexes. The sensitivity of our system ranges between 0.2 and 3.2 micrograms equivalents of aggregated human IgG. We have applied this system to 21 normal healthy controls and 80 neurological patients...

journal_title：Journal of neuroimmunology

authors： Araga S,Irie H,Takahashi K

更新日期：1984-06-01 00:00:00

abstract：:Little is known about the involvement of cytokines in the pathogenesis of primary progressive (PP) multiple sclerosis (MS). We evaluated in this cross-sectional study whether IL-18, IL-12p35, IL-12p40, TNF-alpha, IFN-gamma, IL-10, IL-4, TGF-beta, IL-12Rbeta1, and IL-12Rbeta2 mRNA expression in unstimulated white blood...

journal_title：Journal of neuroimmunology

authors： van Boxel-Dezaire AH,Smits M,van Trigt-Hoff SC,Killestein J,van Houwelingen JC,Polman CH,Nagelkerken L

更新日期：2001-11-01 00:00:00

abstract：:Mice may be protected from the invariably fatal consequences of intracerebral (i.c.) inoculation of A/WSN influnza virus by intravenous injection with 0.5 mg of virus-specific monoclonal anti-hemagglutinin antibody given 2 days after i.c. challenge. The integrity of the blood-cerebrospinal fluid (CSF) barrier in such ...

journal_title：Journal of neuroimmunology

authors： Doherty PC,Gerhard W

更新日期：1981-09-01 00:00:00

abstract：:We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate int...

journal_title：Journal of neuroimmunology

authors： Fabian RH,Hulsebosch CE

更新日期：1989-10-01 00:00:00

abstract：:In order to study the role of interleukin-1beta (IL-1beta) in homeostasis, hypoxia and recovery of neuronal cells, we studied the expression and release of tumor necrosis factor-alpha (TNF-alpha) and nerve growth factor (NGF), in relation to the presence or absence of this cytokine in culture medium. Moreover, we eval...

journal_title：Journal of neuroimmunology

authors： Di Loreto S,Corvetti L,Maccarone R,Piancatelli D,Adorno D

更新日期：2000-07-01 00:00:00

abstract：:Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that T...

journal_title：Journal of neuroimmunology

authors： Huang Q,Ma X,Zhu DL,Chen L,Jiang Y,Zhou L,Cen L,Pi R,Chen X

更新日期：2015-07-15 00:00:00

abstract：:Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by priming and tolerising T cells. DC capture and process antigens, express co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. In multiple sclerosis (MS), autoreactive T c...

journal_title：Journal of neuroimmunology

authors： Huang YM,Xiao BG,Ozenci V,Kouwenhoven M,Teleshova N,Fredrikson S,Link H

更新日期：1999-09-01 00:00:00

abstract：:The immunosuppressive nature of glucocorticoids has been well documented both in vitro and in vivo. This glucocorticoid-mediated immunosuppression has also been observed in immune cells within the central nervous system (CNS). For example, microglia have previously been shown to exhibit decreased proliferation, cytoki...

journal_title：Journal of neuroimmunology

authors： Nair A,Bonneau RH

更新日期：2006-02-01 00:00:00

abstract：:Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express ...

journal_title：Journal of neuroimmunology

authors： Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

更新日期：2006-09-01 00:00:00

abstract：:We report human leukocyte antigen (HLA) class I expression in 5-17% and class II in 0-9% of first trimester human spinal cord cells. After 8 days in culture with gamma-interferon, >87% of the spinal cord cells expressed HLA class II. However, mixed cultures of adult human peripheral lymphocytes and immature human spin...

journal_title：Journal of neuroimmunology

authors： Akesson E,Markling L,Kjaeldgaard A,Falci S,Ringdén O

更新日期：2000-11-01 00:00:00

abstract：:Serum levels of immunoreactive interleukin-2 (IL-2) were determined at monthly intervals from a group of placebo- and drug-treated chronic progressive multiple sclerosis patients before and during a cyclosporine A therapeutic trial. Significantly elevated levels of the lymphokine in active patients confirmed earlier s...

journal_title：Journal of neuroimmunology

authors： Trotter JL,van der Veen RC,Clifford DB

更新日期：1990-06-01 00:00:00

abstract：:Nogo-A is a protein associated with central nervous system (CNS) myelin thought to impair regenerative responses and to suppress sprouting and plastic changes of synaptic terminals. In this study, we report that serum IgM autoantibodies to the recombinant large N-terminal inhibitory domain of Nogo-A are a frequent fin...

journal_title：Journal of neuroimmunology

authors： Reindl M,Khantane S,Ehling R,Schanda K,Lutterotti A,Brinkhoff C,Oertle T,Schwab ME,Deisenhammer F,Berger T,Bandtlow CE

更新日期：2003-12-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is emerging as an important modulator of the function of the central nervous system. In the present study, we investigated a role of endogenous TNF-alpha in cognitive and emotional function using mice with targeted deletions of the TNF-alpha gene. TNF-alpha-(-/-) mice showed nor...

journal_title：Journal of neuroimmunology

authors： Yamada K,Iida R,Miyamoto Y,Saito K,Sekikawa K,Seishima M,Nabeshima T

更新日期：2000-11-01 00:00:00

abstract：:Transplantation of a pituitary graft under the kidney capsule and the resulting elevation of serum prolactin enhances the primary humoral antibody response to sheep red blood cells. Enhancement of the response is not due to marked changes in the percentage of T-cells and their subsets, B-cells, or the number of nuclea...

journal_title：Journal of neuroimmunology

authors： Cross RJ,Campbell JL,Roszman TL

更新日期：1989-11-01 00:00:00

abstract：:Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neur...

journal_title：Journal of neuroimmunology

authors： Guasp M,Solà-Valls N,Martínez-Hernández E,Gil MP,González C,Brieva L,Saiz A,Dalmau J,Graus F,Ariño H

更新日期：2016-11-15 00:00:00

abstract：:The expression of class I major histocompatibility complex (MHC) mRNA was compared in the brains of inflammatory susceptible, hypothalamic-pituitary-adrenal (HPA)-axis blunted Lewis rats and inflammatory resistant, HPA-axis hyperresponsive Fischer rats by quantitative in situ hybridization following lipopolysaccharide...

journal_title：Journal of neuroimmunology

authors： Puchowicz M,Tonelli LH,Sternberg EM

更新日期：2003-01-01 00:00:00

abstract：:Interleukin-10 is a potent immunomodulatory cytokine with possible implications for the pathogenesis of multiple sclerosis. Increased IL10 mRNA expression is associated with stable disease. The interleukin 10 gene is highly polymorphic and certain haplotypes result in differential interleukin-10 expression. The presen...

journal_title：Journal of neuroimmunology

authors： Mäurer M,Kruse N,Giess R,Toyka KV,Rieckmann P

更新日期：2000-04-03 00:00:00

abstract：:For the epigenetic characterization of myasthenia gravis (MG), we determined whether long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) are expressed differentially in subjects with and without MG. Compared with healthy control subjects, the MG patients had 1561 upregulated lncRNAs, 1034 downregulated lncRNAs, 9...

journal_title：Journal of neuroimmunology

authors： Zhang F,Liu G,Bu Y,Ma X,Hao J

更新日期：2016-10-15 00:00:00

abstract：:Rat thymocytes incubated in RPMI medium for 120-300 min release a soluble factor of molecular weight below 10,000 Da which inhibits the binding of 3H-labeled muscarinic antagonists in an uncompetitive manner, i.e. it reduces maximal specific binding (Bmax) without changing the affinity of the ligand (KD). This factor ...

journal_title：Journal of neuroimmunology

authors： Maslinski W,Ryzewski J,Bartfai T

更新日期：1988-03-01 00:00:00

abstract：:Transient global cerebral ischemia elicits a nearly total neuronal cell death in the hippocampal CA1 sector, accompanied by a marked microglial and astroglial proliferation. The molecular mechanisms regulating the postischemic glial reaction in the primate brain remain obscure. Here we present in situ evidence that pr...

journal_title：Journal of neuroimmunology

authors： Tonchev AB,Boneva NB,Kaplamadzhiev DB,Kikuchi M,Mori Y,Sahara S,Yamashima T

更新日期：2008-12-15 00:00:00

abstract：:CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Inv...

journal_title：Journal of neuroimmunology

authors： Jung C,Stoeckle C,Wiesmüller KH,Laub R,Emmrich F,Jung G,Melms A

更新日期：2008-09-15 00:00:00

abstract：:We examined the potential expression and function of alpha7 nicotinic acetylcholine receptors (nAChRs) in leukocytes. RT-PCR with alpha7 specific primers revealed the presence of the receptor mRNA in leukocytes. Immunoblotting and immunofluorescence experiments demonstrated the expression of a protein that is recogniz...

journal_title：Journal of neuroimmunology

authors： Villiger Y,Szanto I,Jaconi S,Blanchet C,Buisson B,Krause KH,Bertrand D,Romand JA

更新日期：2002-05-01 00:00:00

abstract：:The NF-κB signalling pathway plays an important role in controlling cellular immune responses, inflammation and apoptosis. In multiple sclerosis (MS), there is evidence of dysregulation of NF-κB signalling in patients with a relapsing-remitting disease course, but thus far there is little information on whether it is ...

journal_title：Journal of neuroimmunology

authors： Yan J,Winterford CM,Catts VS,Pat BK,Pender MP,McCombe PA,Greer JM

更新日期：2018-07-15 00:00:00

abstract：:Nitric oxide (NO) is implicated in inflammation and hypothalamic-pituitary responses to immune stimuli; however, the specific role of NO from neurons during stress-induced immune responses remains unspecified. We measured antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and ...

journal_title：Journal of neuroimmunology

authors： Bilbo SD,Hotchkiss AK,Chiavegatto S,Nelson RJ

更新日期：2003-07-01 00:00:00