MHC antigen expression in human first trimester spinal cord with implications for clinical transplantation procedures.

abstract：:Growing evidence suggests a role for brain-gut-microbiota axis in affective disorders including major depression and bipolar disorder (BD). Herein, we aim to explore, by employing germ-free (GF) mice, the effect of the indigenous microbiota in the development of mania-like behavior. Conventional and GF mice were evalu...

journal_title：Journal of neuroimmunology

authors： de Miranda AS,Vieira ÉLM,Dos Reis Bastos J,Ferreira RN,Nicoli JR,Teixeira MM,Vieira LQ,Moreira FA,Teixeira AL

更新日期：2020-06-16 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions a...

journal_title：Journal of neuroimmunology

authors： Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

更新日期：2003-05-01 00:00:00

abstract：:Melatonin is known as an antistress and immunostimulator compound while glucocorticoids have immunosuppressive function. The mechanism of action of both the hormones on immune cells is still a question. We found that melatonin improved the effect of dexamethasone (synthetic glucocorticoid) induced immunosuppression of...

journal_title：Journal of neuroimmunology

authors： Vishwas DK,Mukherjee A,Haldar C

更新日期：2013-06-15 00:00:00

abstract：:The blood brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCB) limit the influx of immune mediators and bloodstream compounds into the central nervous system (CNS). Upon injury or infection, the integrity of these barriers is compromised and leukocyte infiltration occurs. The BCB is located in the choro...

journal_title：Journal of neuroimmunology

authors： Alvarez JI,Teale JM

更新日期：2007-07-01 00:00:00

abstract：:The concentrations of beta-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, beta-endorphin concentrations in mononuclear cells, increased aft...

journal_title：Journal of neuroimmunology

authors： Sacerdote P,Rubboli F,Locatelli L,Ciciliato I,Mantegazza P,Panerai AE

更新日期：1991-04-01 00:00:00

abstract：:Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

journal_title：Journal of neuroimmunology

authors： Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

更新日期：2002-06-01 00:00:00

abstract：:We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

journal_title：Journal of neuroimmunology

authors： Stevens DB,Gould KE,Swanborg RH

更新日期：1994-04-01 00:00:00

abstract：:Based on gene expression data, we tested the P8A-CCL2 variant of the chemokine CCL2, able to interfere with the chemotactic properties of the parental molecule, in relapsing-remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a dose dependent manner. P8A-CCL2 administration, howeve...

journal_title：Journal of neuroimmunology

authors： Brini E,Ruffini F,Bergami A,Brambilla E,Dati G,Greco B,Cirillo R,Proudfoot AE,Comi G,Furlan R,Zaratin P,Martino G

更新日期：2009-04-30 00:00:00

abstract：:We investigated the role of IFN-gamma activated microglia in the passage of T lymphocytes across a monolayer of brain endothelial cells (EC) in vitro. Microglia isolated from Fisher 344 (F344) newborn rats were stimulated with IFN-gamma (100 U/ml) for 48 h. T lymphocytes primed with glioma cells were 51Cr-labeled, and...

journal_title：Journal of neuroimmunology

authors： Watanabe T,Tanaka R,Taniguchi Y,Yamamoto K,Ono K,Yoshida S

更新日期：1998-01-01 00:00:00

abstract：:Methadone is known to exert modulatory effects on the immune system. We investigated the potential effects of methadone on infiltration of inflammatory cells into the spinal cord, as well as the proliferative and cytokine responses of T cells in MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice. Met...

journal_title：Journal of neuroimmunology

authors： Kafami L,Etesami I,Felfeli M,Enayati N,Ghiaghi R,Aminian A,Dehpour A

更新日期：2013-02-15 00:00:00

abstract：:This study aimed to evaluate the effects of leptin, ghrelin and neuropeptide-Y on the development of nonconvulsive seizure activity and their role on combating oxidative stress and cytokines produced by the systemic immune response in the WAG/Rij rat model for genetic absence epilepsy. Current study showed that all th...

journal_title：Journal of neuroimmunology

authors： Oztas B,Sahin D,Kir H,Kuskay S,Ates N

更新日期：2021-02-15 00:00:00

abstract：:We have previously found a dramatic increase of corticotropin-releasing factor receptor (CRF-R1) production in splenic neutrophils of male C57BL/6N mice after application of an immunological stimulus. We demonstrate here that immobilization, a predominantly psychological stress, exhibited a similar effect. Shortly aft...

journal_title：Journal of neuroimmunology

authors： Radulovic M,Weber C,Spiess J

更新日期：2000-03-01 00:00:00

abstract：:Transplantation of a pituitary graft under the kidney capsule and the resulting elevation of serum prolactin enhances the primary humoral antibody response to sheep red blood cells. Enhancement of the response is not due to marked changes in the percentage of T-cells and their subsets, B-cells, or the number of nuclea...

journal_title：Journal of neuroimmunology

authors： Cross RJ,Campbell JL,Roszman TL

更新日期：1989-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory immune response directed against myelin antigens of the central nervous system. In its murine model, EAE, Th17 cells play an important role in disease pathogenesis. These cells can induce blood-brain barrier disruption and CNS immune cells ...

journal_title：Journal of neuroimmunology

authors： Peron JP,Yang K,Chen ML,Brandao WN,Basso AS,Commodaro AG,Weiner HL,Rizzo LV

更新日期：2010-10-08 00:00:00

abstract：:Plaque classification is proposed based on observation of 348 plaques from 52 post-mortem multiple sclerosis (MS) cases. Four plaque types, ranging from 'earliest lesion' to 'inactive', are described according to immunological activation and degree of demyelination, seen by expression of the Major Histocompatibility C...

journal_title：Journal of neuroimmunology

authors： Sanders V,Conrad AJ,Tourtellotte WW

更新日期：1993-07-01 00:00:00

abstract：:We examined the effect of gallium (Ga) nitrate on the development of the development of experimental autoimmune encephalomyelitis (EAE). Weekly subcutaneous injections of 10-30 mg/kg prevented clinical signs as well as histopathological changes of EAE. The optimal timing of a single injection of Ga was 6 days after in...

journal_title：Journal of neuroimmunology

authors： Whitacre C,Apseloff G,Cox K,Matkovic V,Jewell S,Gerber N

更新日期：1992-07-01 00:00:00

abstract：:The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with 51Cr-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not ne...

journal_title：Journal of neuroimmunology

authors： Argall KG,Armati PJ,Pollard JD,Bonner J

更新日期：1992-09-01 00:00:00

abstract：:A cross-reactive idiotope (CRI) has been previously described on monoclonal antibodies (mAbs) specific for encephalitogenic peptides from myelin basic protein (MBP). The anti-CRI mAb, F25F7, binds an idiotope (Id) localized to the light chains of an anti-MBP peptide 1-9 mAb, denoted F23C6, and an anti-MBP peptide 80-8...

journal_title：Journal of neuroimmunology

authors： Maier CC,LeBoeuf RD,Zhou SR,Whitaker JN,Jarpe MA,Blalock JE

更新日期：1993-07-01 00:00:00

abstract：:Ischemic stroke is one of the leading causes of mortality and morbidity in humans. During brain ischemia and the subsequent reperfusion that occurs with stroke, the generation of the so-called "proinflammatory" prostaglandin E(2) (PGE(2)) increases significantly. Therefore, interest is growing regarding the differenti...

journal_title：Journal of neuroimmunology

authors： Saleem S,Kim YT,Maruyama T,Narumiya S,Doré S

更新日期：2009-03-31 00:00:00

abstract：:Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central...

journal_title：Journal of neuroimmunology

authors： Portegies P,Godfried MH,Hintzen RQ,Stam J,van der Poll T,Bakker M,van Deventer SJ,van Lier RA,Goudsmit J

更新日期：1993-11-01 00:00:00

abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

journal_title：Journal of neuroimmunology

authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

更新日期：2016-01-15 00:00:00

abstract：:We recently showed that MMP-9 activity was detectable in the cerebrospinal fluid (CSF) of about half of neurologically symptomatic HIV-infected patients. Using an experimental animal model, we detected MMP-9 activity in CSF samples from rats that had been injected intracisternally with recombinant HIV-1 Nef protein, b...

journal_title：Journal of neuroimmunology

authors： Sporer B,Koedel U,Paul R,Kohleisen B,Erfle V,Fontana A,Pfister HW

更新日期：2000-01-24 00:00:00

abstract：:A 20 h continuous treatment of rats with catecholamines, using subcutaneously implantable retard tablets, had either no (adrenaline, isoproterenol, midodrine) or a slight (noradrenaline) suppressive effect on the in vitro responsiveness of peripheral blood T-lymphocytes. A marked suppression of the mitogen response en...

journal_title：Journal of neuroimmunology

authors： Felsner P,Hofer D,Rinner I,Mangge H,Gruber M,Korsatko W,Schauenstein K

更新日期：1992-03-01 00:00:00

abstract：:Activated CD4+ T lymphocytes specific for myelin basic protein (MBP) can cause experimental autoimmune encephalomyelitis (EAE) upon their inoculation into syngeneic recipients. In Lewis rats, most of the pathogenic T cell clones that develop following immunization with MBP are reactive against the 72-84 amino acid seq...

journal_title：Journal of neuroimmunology

authors： Beraud E,Balzano C,Zamora AJ,Varriale S,Bernard D,Ben-Nun A

更新日期：1993-08-01 00:00:00

abstract：:Stroke may be accompanied by immunological consequences including local autoimmunity and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the immune system gain direct access to the brain parenchyma. Here local autoimmunity contributes to lesion formation and, in experimental stroke, ...

journal_title：Journal of neuroimmunology

authors： Vogelgesang A,Dressel A

更新日期：2011-02-01 00:00:00

abstract：:Screening with a 7-mer phage display peptide library, a panel of cell-targeting peptides for the murine microglial cell line, EOC 20, was recognized. A number of similar, but not identical, sets of sequences representing more than 75% of all the cell line-binding clones were identified. Comparative analysis indicated ...

journal_title：Journal of neuroimmunology

authors： Samoylova TI,Ahmed BY,Vodyanoy V,Morrison NE,Samoylov AM,Globa LP,Baker HJ,Cox NR

更新日期：2002-06-01 00:00:00

abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

journal_title：Journal of neuroimmunology

authors： Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

更新日期：2012-11-15 00:00:00

abstract：:The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterize...

journal_title：Journal of neuroimmunology

authors： Gallo P,Piccinno MG,De Rossi A,Pagni S,Amadori A,Chieco-Bianchi L,Tavolato B

更新日期：1990-03-01 00:00:00

abstract：:Peripheral circulating cytokines are involved in immune to brain communication and systemic inflammation is considered a risk factor for flaring up the symptoms in most neurodegenerative diseases. We induced both central inflammatory demyelinating lesion, and systemic inflammation with an interleukin-1β expressing ade...

journal_title：Journal of neuroimmunology

authors： Murta V,Farías MI,Pitossi FJ,Ferrari CC

更新日期：2015-01-15 00:00:00

abstract：:To illustrate the accuracy of the fluorescence-activated cell sorting cell-based assay (FACS-CBA) and to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies and ascertain the optimal method for positivity judgement, referencing the findings of microscopic CBA. We tested serum anti-MOG antibodies in 57 pat...

journal_title：Journal of neuroimmunology

authors： Sugimoto K,Mori M,Liu J,Tanaka S,Kaneko K,Oji S,Takahashi T,Uzawa A,Uchida T,Masuda H,Ohtani R,Nomura K,Hiwasa T,Kuwabara S

更新日期：2019-11-15 00:00:00