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The effect of acute immobilization stress on the abundance of corticotropin-releasing factor receptor in lymphoid organs.

Abstract：

:We have previously found a dramatic increase of corticotropin-releasing factor receptor (CRF-R1) production in splenic neutrophils of male C57BL/6N mice after application of an immunological stimulus. We demonstrate here that immobilization, a predominantly psychological stress, exhibited a similar effect. Shortly after 90 min of immobilization, the number of splenic CRF-RI+ cells was transiently increased by nearly 8-fold, while it was reduced in thymus and unchanged in lymph nodes. The CRF-R1+ cells were detected by an affinity-purified polyclonal antibody directed against the N-terminus of CRF-R1, and identified as neutrophils, eosinophils or their immature precursors on the basis of their nuclear shapes, Wright-Giemsa staining and colocalization of CRF-R1 with the ER-MP58 antigen.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Radulovic M,Weber C,Spiess J

doi

10.1016/s0165-5728(99)00229-5

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

153-64

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572899002295

journal_volume

103

pub_type

杂志文章

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