Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.

Abstract:

:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS.

journal_name

J Neuroimmunol

authors

Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

doi

10.1016/j.jneuroim.2010.05.034

subject

Has Abstract

pub_date

2010-09-14 00:00:00

pages

81-92

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00241-9

journal_volume

226

pub_type

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