Abstract:
:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RPdoi
10.1016/j.jneuroim.2010.05.034subject
Has Abstractpub_date
2010-09-14 00:00:00pages
81-92issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(10)00241-9journal_volume
226pub_type
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