当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Early major histocompatibility complex (MHC) class I antigen induction in hypothalamic supraoptic and paraventricular nuclei in trypanosome-infected rats.

Early major histocompatibility complex (MHC) class I antigen induction in hypothalamic supraoptic and paraventricular nuclei in trypanosome-infected rats.

Abstract：

:Sprague-Dawley rats were injected intraperitoneally with a suspension of Trypanosoma brucei brucei. An early induction of major histocompatibility complex (MHC) class I antigens as well as an infiltration of macrophage-like cells and cytotoxic T-cells was detected with immunohistochemical techniques in circumventricular organs, such as the median eminence, neurohypophysis, subfornical organ, pineal gland and area postrema. These areas, which lack a blood-brain barrier, correspond to those showing early invasion of trypanosomes. In addition, there was a marked induction of MHC class I in neurons in two hypothalamic nuclei, the paraventricular and supraoptic nuclei. Neurons in these two nuclei are located behind the blood-brain barrier, but project to the neurohypophysis and to the median eminence, thereby exposing their axon terminals to factors circulating in the blood or released locally from invading trypanosomes or from macrophages or cytotoxic T-cells. It is suggested that the alteration in the nerve cell bodies in the hypothalamic nuclei is caused by retrograde axonal signals from these target areas.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Schultzberg M,Olsson T,Samuelsson EB,Maehlen J,Kristensson K

doi

10.1016/0165-5728(89)90104-5

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

105-12

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(89)90104-5

journal_volume

24

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain.

    abstract：:A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynaptic adrenergic sensitivity as well...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00244-7

    authors： Nickola TJ,Ignatowski TA,Spengler RN

    更新日期：2000-07-10 00:00:00

  • Breakdown of the blood--cerebrospinal fluid barrier to immunoglobulin in mice injected intracerebrally with a neurotropic influenza A virus. Post-exposure treatment with monoclonal antibody promotes recovery.

    abstract：:Mice may be protected from the invariably fatal consequences of intracerebral (i.c.) inoculation of A/WSN influnza virus by intravenous injection with 0.5 mg of virus-specific monoclonal anti-hemagglutinin antibody given 2 days after i.c. challenge. The integrity of the blood-cerebrospinal fluid (CSF) barrier in such ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(81)90027-8

    authors： Doherty PC,Gerhard W

    更新日期：1981-09-01 00:00:00

  • Studies on terminal deoxynucleotidyl transferase and adenosine deaminase in myasthenic thymus.

    abstract：:Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(84)90067-5

    authors： Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

    更新日期：1984-09-01 00:00:00

  • Splenectomy following MCAO inhibits the TLR4-NF-κB signaling pathway and protects the brain from neurodegeneration in rats.

    abstract：BACKGROUND AND PURPOSE:The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlyin...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.03.003

    authors： Belinga VF,Wu GJ,Yan FL,Limbenga EA

    更新日期：2016-04-15 00:00:00

  • Multiple sclerosis patients show sexual dimorphism in cytokine responses to myelin antigens.

    abstract：:Multiple sclerosis affects more women than men. The reasons for this are unknown. Previously, we have shown significant differences in women versus men in inflammatory cytokine responses to the major protein component of myelin, proteolipid protein (PLP), which is thought to be a target in MS patients. Here, using the...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.10.010

    authors： Moldovan IR,Cotleur AC,Zamor N,Butler RS,Pelfrey CM

    更新日期：2008-01-01 00:00:00

  • Circulating T-cell subsets in Guillain-Barré syndrome.

    abstract：:We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8+ (putative suppressor...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(85)80050-3

    authors： Lisak RP,Zweiman B,Guerrero F,Moskovitz AR

    更新日期：1985-05-01 00:00:00

  • Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.

    abstract：:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.05.034

    authors： Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

    更新日期：2010-09-14 00:00:00

  • Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy.

    abstract：:We investigated potential therapeutic effects of sphingosine-1-phosphate (S1P) receptor modulators FTY720 (fingolimod) and selective S1P1 agonist SEW2871 on a spontaneous autoimmune polyneuropathy (SAP) when given orally at 7 mo (anticipated disease onset) for 4 weeks. Clinical severity, electrophysiologic and histolo...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.07.006

    authors： Kim HJ,Jung CG,Dukala D,Bae H,Kakazu R,Wollmann R,Soliven B

    更新日期：2009-09-29 00:00:00

  • Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease.

    abstract：:The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of p...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.09.027

    authors： Delunardo F,Margutti P,Pontecorvo S,Colasanti T,Conti F,Riganò R,Profumo E,Siracusano A,Capozzi A,Prencipe M,Sorice M,Francia A,Ortona E

    更新日期：2007-12-01 00:00:00

  • Chronic restraint stress modulates expression of genes in murine spleen.

    abstract：:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.05.004

    authors： Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

    更新日期：2006-08-01 00:00:00

  • Murine cytomegalovirus infection in mice results in an acute inflammatory reaction in peripheral nerves.

    abstract：:Human cytomegalovirus (CMV) infection is asymptomatic in immunocompetent individuals. However, it can lead to disease in immunodeficient population. Little is known of the mechanisms underlying the pathogenicity of the virus. We investigated the impact of CMV infection on mouse nervous system. Peripheral nerves but no...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.577017

    authors： Oladiran O,Yang M,Rivera VAG,Shi X,Huang J,Fournier S,Zhang J

    更新日期：2019-10-15 00:00:00

  • Variable patterns of anti-GM(1) IgM-antibody populations defined by affinity and fine specificity in patients with motor syndromes: evidence for their random origin.

    abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00355-1

    authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

    更新日期：2001-09-03 00:00:00

  • MicroRNA expression profiling in Guillain-Barré syndrome.

    abstract：:Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we foun...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.10.014

    authors： Lv Z,Shi Q,Huang W,Xing C,Hao Y,Feng X,Yang Y,Zhang A,Kong Q,Yuki N,Wang Y

    更新日期：2016-12-15 00:00:00

  • Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

    abstract：:Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.01.002

    authors： Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

    更新日期：2014-03-15 00:00:00

  • Inhibition of acetylcholine receptor function by seronegative myasthenia gravis non-IgG factor correlates with desensitisation.

    abstract：:15% of myasthenia gravis (MG) patients do not have antibodies against the acetylcholine receptor (AChR). Some of these "seronegative" MG patients have antibodies against muscle specific kinase (MuSK), and many have a non-IgG factor that acutely inhibits AChR function in a muscle-like cell line, CN21. Here we show, usi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.01.009

    authors： Spreadbury I,Kishore U,Beeson D,Vincent A

    更新日期：2005-05-01 00:00:00

  • Imag(in)ing multiple sclerosis: Time to take better pictures.

    abstract：:Magnetic resonance imaging (MRI) has led to the identification of widespread brain abnormalities in multiple sclerosis (MS) that extend far beyond the classic white matter lesion. These findings have generated the idea that MS should be understood as a disease of the whole brain, not just the white matter. While it is...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2016.09.015

    authors： Reich DS

    更新日期：2017-03-15 00:00:00

  • Induction and regulation of interleukin-6 gene expression in rat astrocytes.

    abstract：:Cells that produce interleukin-6 (IL-6) require the presence of signaling molecules since this cytokine is not normally constitutively expressed. It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. In the cur...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(90)90104-u

    authors： Benveniste EN,Sparacio SM,Norris JG,Grenett HE,Fuller GM

    更新日期：1990-12-01 00:00:00

  • TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation.

    abstract：:VCAM-1 is an adhesion molecule that is important to leukocyte movement across the blood-brain barrier and is involved in the formation of destructive CNS inflammatory lesions in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We examined VCAM-1 expression in the CNS of animals with passive...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.02.012

    authors： Gimenez MA,Sim JE,Russell JH

    更新日期：2004-06-01 00:00:00

  • Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.

    abstract：:Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, is a neuroprotective lipid with anti-inflammatory properties. We investigated the possible therapeutic effect of EPA on experimental autoimmune encephalomyelitis (EAE). EAE mice were fed a diet with or without EPA. The clinical EAE scores of the ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.12.003

    authors： Unoda K,Doi Y,Nakajima H,Yamane K,Hosokawa T,Ishida S,Kimura F,Hanafusa T

    更新日期：2013-03-15 00:00:00

  • Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis.

    abstract：:We investigated in multiple sclerosis the difference between two commonly used oral and intravenous steroid regimens on the level of adhesion molecule expression on blood T lymphocytes, the distribution of circulating T cell subsets, and the concentration of serum tumour necrosis factor alpha. Venous blood samples wer...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0165-5728(96)00206-8

    authors： Pitzalis C,Sharrack B,Gray IA,Lee A,Hughes RA

    更新日期：1997-04-01 00:00:00

  • A chemiluminescence assay to detect antibodies to brain surface antigens in human sera.

    abstract：:A chemiluminescence assay was developed based on the interaction between antibodies binding to the surface of living brain cells in culture and macrophages. Such interaction leads to production of reactive oxygen radicals which can be measured by a chemiluminescence assay. This assay was used to detect anti brain anti...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90199-6

    authors： Brügger M,Dayrell-Hart E,Meier C,Vandevelde M,Zurbriggen A

    更新日期：1994-01-01 00:00:00

  • The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis.

    abstract：:Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomy...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90003-9

    authors： Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

    更新日期：1989-03-01 00:00:00

  • Comparison of T8+ cell-mediated suppressor and cytotoxic functions in multiple sclerosis.

    abstract：:Patients with progressive multiple sclerosis (MS) and controls were compared with regard to: (a) in vitro pokeweed mitogen (pwm)-induced IgG secretion, as an indirect measure of T8+ cell-mediated suppressor function; (b) alloantigen-directed cytotoxic activity, a predominantly T8+ cell-mediated function. The MS group ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(86)80005-4

    authors： Antel JP,Nicholas MK,Bania MB,Reder AT,Arnason BG,Joseph L

    更新日期：1986-09-01 00:00:00

  • Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).

    abstract：:IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals an...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.02.014

    authors： Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

    更新日期：2010-05-01 00:00:00

  • Increase of matrix metalloproteinase-9 in peripheral blood of multiple sclerosis patients treated with high doses of methylprednisolone.

    abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jneuroim.2003.10.046

    authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

    更新日期：2004-01-01 00:00:00

  • Participation of iNOS-derived NO in hypothalamic activation and vasopressin release during polymicrobial sepsis.

    abstract：:Clinical and experimental studies with LPS injection have shown an increase in vasopressin (AVP) secretion in the early phase of severe sepsis, which is subsequently reduced despite persistent hypotension. The aim of this study was to evaluate the role of inducible nitric oxide synthase (iNOS)-derived NO in hypothalam...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.10.021

    authors： Corrêa PB,Pancoto JA,de Oliveira-Pelegrin GR,Cárnio EC,Rocha MJ

    更新日期：2007-02-01 00:00:00

  • Monocytes in active multiple sclerosis: intact regulation of HLA-DR density in vitro despite decreased HLA-DR density in vivo.

    abstract：:HLA-DR expression on circulating monocytes varies as a function of disease activity in patients with multiple sclerosis (MS), a putative immunopathological demyelinating disorder. Specifically, monocytes isolated from subjects with active MS exhibit reduced HLA-DR antigen density, and immunoregulatory aberrations such...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90001-2

    authors： Ransohoff RM,Tuohy VK,Barna BP,Rudick RA

    更新日期：1992-04-01 00:00:00

  • Persistent immune activation associated with a mouse model of Staphylococcus aureus-induced experimental brain abscess.

    abstract：:We have established a mouse experimental brain abscess model using Staphylococcus aureus where lesion sites are greatly exaggerated compared to the localized area of initial infection, reminiscent of an overactive immune response. Here we demonstrate the prolonged expression of IL-1 beta, TNF-alpha, and macrophage inf...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.02.002

    authors： Baldwin AC,Kielian T

    更新日期：2004-06-01 00:00:00

  • Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex.

    abstract：:Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90198-8

    authors： Portegies P,Godfried MH,Hintzen RQ,Stam J,van der Poll T,Bakker M,van Deventer SJ,van Lier RA,Goudsmit J

    更新日期：1993-11-01 00:00:00

  • Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis.

    abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90001-2

    authors： Willenborg DO,Prowse SJ

    更新日期：1983-10-01 00:00:00