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TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation.

Abstract：

:VCAM-1 is an adhesion molecule that is important to leukocyte movement across the blood-brain barrier and is involved in the formation of destructive CNS inflammatory lesions in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We examined VCAM-1 expression in the CNS of animals with passively induced EAE and found abundant expression not only on the CNS endothelium but also on astrocytes. We show that tumor necrosis factor receptor-1 (TNFR1) signaling is required for VCAM-1 expression by astrocytes, not the vascular endothelium. In addition, we demonstrate that VCAM-1 expression by astrocytes is crucial for T cell entry into the CNS parenchyma and is required for manifestation of neurological disease.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Gimenez MA,Sim JE,Russell JH

doi

10.1016/j.jneuroim.2004.02.012

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

116-25

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572804000839

journal_volume

151

pub_type

杂志文章

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