Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis.

Abstract:

:G-protein-coupled receptors (GPCR) play an important role in inflammation. Their responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and beta-arrestins. We show here that induction of experimental autoimmune encephalomyelitis (EAE) by myelin oligodendrocyte glycoprotein (MOG) resulted in a profound decrease in GRK2 and GRK6 protein in splenocytes during all phases of disease. GRK2 mRNA was also lower during EAE, although the decrease in mRNA was less pronounced than the decrease in GRK2 protein. Interestingly, beta-arrestin protein expression was significantly increased. Downregulation of GRK2 was restricted to the spleen and mesenteric lymph nodes and was not observed in peritoneal macrophages. Furthermore, EAE did not induce alterations in GRK2 expression in heart, liver and pituitary.

journal_name

J Neuroimmunol

authors

Vroon A,Lombardi MS,Kavelaars A,Heijnen CJ

doi

10.1016/s0165-5728(03)00050-x

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

79-86

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S016557280300050X

journal_volume

137

pub_type

杂志文章
  • Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex.

    abstract::Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(93)90198-8

    authors: Portegies P,Godfried MH,Hintzen RQ,Stam J,van der Poll T,Bakker M,van Deventer SJ,van Lier RA,Goudsmit J

    更新日期:1993-11-01 00:00:00

  • Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.

    abstract::The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression i...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2008.06.011

    authors: André C,O'Connor JC,Kelley KW,Lestage J,Dantzer R,Castanon N

    更新日期:2008-08-30 00:00:00

  • Restriction fragment length polymorphism analysis of HLA-DR- and DQ-linked alleles in multiple sclerosis in Spain.

    abstract::HLA-DR allele subtypes in multiple sclerosis (MS) individuals in Spain were determined by restriction fragment length polymorphism (RFLP) analysis. The well-established association of DRw15, DQw6, Dw2 alleles and MS susceptibility was confirmed. The strength of its association, however, was relatively weak in our MS p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(92)90076-w

    authors: Clerici N,Fernández M

    更新日期:1992-12-01 00:00:00

  • Omega-3 polyunsaturated fatty acids ameliorate neuroinflammation and mitigate ischemic stroke damage through interactions with astrocytes and microglia.

    abstract::Omega-3 polyunsaturated fatty acids (PUFA n3) provide neuroprotection due to their anti-inflammatory and anti-apoptotic properties as well as their regulatory function on growth factors and neuronal plasticity. These qualities enable PUFA n3 to ameliorate stroke outcome and limit neuronal damage. Young adult male rats...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.11.007

    authors: Zendedel A,Habib P,Dang J,Lammerding L,Hoffmann S,Beyer C,Slowik A

    更新日期:2015-01-15 00:00:00

  • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant.

    abstract::Traumatic brain injury triggers a cascade of events resulting in delayed edema, necrosis and impaired function. Harmful mediators are accumulating in the brain after injury and recently, the role of cytokines in the pathophysiology of brain injury has been suggested. We have developed an experimental model for closed ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-5728(96)00181-6

    authors: Shohami E,Gallily R,Mechoulam R,Bass R,Ben-Hur T

    更新日期:1997-02-01 00:00:00

  • Increased serum acetylcholine receptor α1 subunit protein in anti-acetylcholine receptor antibody-positive myasthenia gravis.

    abstract::Complement-dependent disruption of motor endplate is detected in anti-acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG). We measured serum AChR α1 subunit protein levels, which may be associated with neuromuscular damage, in 55 patients with MG (47 were seropositive and 8 were negative) and in 20 ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2019.577125

    authors: Uzawa A,Ozawa Y,Yasuda M,Oda F,Kojima Y,Kawaguchi N,Kanai T,Himuro K,Kuwabara S

    更新日期:2020-02-15 00:00:00

  • Quantitative analysis of the cellular constituents of the cerebrospinal fluid in chronic relapsing experimental allergic encephalomyelitis.

    abstract::Cerebrospinal fluid (CSF) was taken from guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CR-EAE). The leucocytes in CSF samples were counted and subjected to immunocytochemical analysis using monoclonal antibodies selectively recognising guinea pig T cells, macrophages or Ia...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(86)90075-5

    authors: Suckling AJ,Baron PW,Mauer U,Burger R,Rumsby MG

    更新日期:1986-03-01 00:00:00

  • Induction of TRAIL-mediated glioma cell death by human T cells.

    abstract::Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(01)00450-7

    authors: Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

    更新日期:2002-01-01 00:00:00

  • Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats.

    abstract::Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). To better understand the mechanism of disease relapse, we induced acute and chronic ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(02)00147-9

    authors: Jee Y,Yoon WK,Okura Y,Tanuma N,Matsumoto Y

    更新日期:2002-07-01 00:00:00

  • Monoclonal antibodies to central nervous system antigens.

    abstract::Thirty monoclonal antibodies produced by mouse hybrid myelomas which react with antigens in hamster or mouse nervous system tissues were derived. Using these antibodies as probes with indirect immunofluorescence and immunoperoxidase techniques, we can selectively identify by morphological criteria many of the structur...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(81)90019-9

    authors: Franko MC,Masters CL,Gibbs CJ Jr,Gajdusek DC

    更新日期:1981-12-01 00:00:00

  • Autoantibody repertoires to brain tissue in autism nuclear families.

    abstract::The hypothesis of an immune dysfunction in autism spectrum disorders has previously been put forward without, however, compelling evidence of a direct relation to its etiology or pathogenesis. To further understand if autoimmunity could play a significant role in autism, we analyzed autoantibody repertoires to brain t...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2004.03.015

    authors: Silva SC,Correia C,Fesel C,Barreto M,Coutinho AM,Marques C,Miguel TS,Ataide A,Bento C,Borges L,Oliveira G,Vicente AM

    更新日期:2004-07-01 00:00:00

  • Region-specific immunoassays for human myelin basic protein.

    abstract::Three monoclonal antibodies reactive with human myelin basic protein have been used to develop immunoradiometric assays for this protein. Clone 1, a mouse IgG2a, is reactive with an epitope in the region 129-138. Clone 2, a mouse IgG1, is reactive with the region 119-131. Clone 12, a rat IgG, is reactive with the regi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(86)90032-9

    authors: Groome NP,Dawkes A,Gales M,Hruby S,Alvord EC Jr

    更新日期:1986-10-01 00:00:00

  • HuR, a novel target of anti-Hu antibodies, is expressed in non-neural tissues.

    abstract::Paraneoplastic encephalomyelitis (PEM) is characterized by a diverse set of clinical signs that are limited to the nervous system. The serologic hallmark of PEM is the presence of circulating autoantibodies, collectively referred to as 'anti-Hu,' which immunoreact specifically with members of the Elav protein family. ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(98)00196-9

    authors: Nabors LB,Furneaux HM,King PH

    更新日期:1998-12-01 00:00:00

  • Upregulation of interleukin (IL)-31, a cytokine producing CXCR1 peripheral immune cells, contributes to the immune abnormalities of autism spectrum disorder.

    abstract::Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by communication deficits, impaired social interactions, and restricted stereotypical behaviors. Several immune cells are associated with immune dysfunction in ASD; however, IL-31 has not been explored in ASD. This study aims to ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2020.577430

    authors: Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alsaad AMS,Assiri MA,Al-Mazroua HA,Attia SM

    更新日期:2020-12-15 00:00:00

  • Splenectomy following MCAO inhibits the TLR4-NF-κB signaling pathway and protects the brain from neurodegeneration in rats.

    abstract:BACKGROUND AND PURPOSE:The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlyin...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2016.03.003

    authors: Belinga VF,Wu GJ,Yan FL,Limbenga EA

    更新日期:2016-04-15 00:00:00

  • Developmental expression of cell type-specific markers in mouse cerebellar cells in vitro.

    abstract::The expression of several cell type-specific markers was studied by indirect immunofluorescence in discontinuous BSA gradient fractionated and unfractionated mouse cerebellar cells cultured for 3 days in vitro from embryonic day 13 through postnatal day 9. Cell surface antigen NS-4 and tetanus toxin receptors are pres...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(81)90024-2

    authors: Schnitzer J,Schachner M

    更新日期:1981-12-01 00:00:00

  • Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine.

    abstract::Intraplantar (i.pl.) injections of thymulin have been shown to produce hyperalgesia in rats through a prostaglandin E2-dependent mechanism. This study aimed at investigating if such injections can produce sustained activation of spinal neurons by mapping the fos-like-immunoreactivity (FLI) as a marker for this activat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(99)00031-4

    authors: Saadé NE,Lawand HF,Safieh-Garabedian B,Kanaan SA,Atweh SF,Jabbur SJ

    更新日期:1999-06-01 00:00:00

  • Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis.

    abstract::We examined immune function and changes in T cell populations over a 1-year period in a series of progressive multiple sclerosis (MS) patients treated with different regimens of cyclophosphamide/ACTH as part of the Northeast Multiple Sclerosis Treatment Group. Our studies were designed to determine the effect of diffe...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0165-5728(91)90007-t

    authors: Hafler DA,Orav J,Gertz R,Stazzone L,Weiner HL

    更新日期:1991-05-01 00:00:00

  • Prevalence of Small Intestinal Bacterial Overgrowth in Multiple Sclerosis: a Case-Control Study from China.

    abstract:OBJECTIVE:It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS:T...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2016.11.004

    authors: Zhang Y,Liu G,Duan Y,Han X,Dong H,Geng J

    更新日期:2016-12-15 00:00:00

  • Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy.

    abstract::To assess the immunopathological significance of the increased replication of human T-cell leukemia virus type I (HTLV-I) in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) we investigated the dynamics of HTLV-I proviral DNA in peripheral blood mononuclear cells (PBMC) of HAM/TSP patients at differ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(93)90004-i

    authors: Kubota R,Fujiyoshi T,Izumo S,Yashiki S,Maruyama I,Osame M,Sonoda S

    更新日期:1993-02-01 00:00:00

  • TRPV1 polymorphisms and risk of interferon β-induced flu-like syndrome in patients with relapsing-remitting multiple sclerosis.

    abstract::Interferon-β (IFN-β) is often discontinued in RRMS patients due to its most common side effect, the flu-like syndrome (FLS). The mechanisms underlying IFN β-induced FLS symptoms are still unclear. The endocannabinoid system (ECS) is a key regulator of pain and inflammation. Thus we tested the hypothesis that the ECS c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2017.02.007

    authors: Buttari F,Zagaglia S,Marciano L,Albanese M,Landi D,Nicoletti CG,Mercuri NB,Silvestrini M,Provinciali L,Marfia GA,Mori F,Centonze D

    更新日期:2017-04-15 00:00:00

  • Preferential association of V lambda x light chains with gamma 2a heavy chains in naturally occurring human myelin basic protein reactive antibodies.

    abstract::Active immunization with myelin basic protein (MBP) induces experimental allergic encephalomyelitis (EAE) in a variety of animal species, including rats and mice. We have previously described the ability of the newly described mouse lambda (lambda) variable (V) region V lambda x, to confer MBP reactivity to an Ab. In ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(96)00072-0

    authors: Galin FS,Zhou SR,Whitaker JN,Blalock JE

    更新日期:1996-10-01 00:00:00

  • Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration.

    abstract::Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We o...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.07.017

    authors: García-Pérez D,Luisa Laorden M,Núñez C,Victoria Milanés M

    更新日期:2014-09-15 00:00:00

  • Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms.

    abstract::Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a su...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.04.011

    authors: Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

    更新日期:2006-07-01 00:00:00

  • Nerve growth factor antibody exacerbates neuropathological signs of experimental allergic encephalomyelitis in adult lewis rats.

    abstract::In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(99)00272-6

    authors: Micera A,Properzi F,Triaca V,Aloe L

    更新日期:2000-05-01 00:00:00

  • Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures.

    abstract::Rasmussen's encephalitis (RE) is a rare condition characterized by drug-resistant seizures, recurrent status epilepticus and progressive lateralized neurological deterioration. There is evidence of autoimmune involvement in the pathogenesis. We investigated the presence of anti-GluR3 antibodies against peptides A and ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(02)00261-8

    authors: Mantegazza R,Bernasconi P,Baggi F,Spreafico R,Ragona F,Antozzi C,Bernardi G,Granata T

    更新日期:2002-10-01 00:00:00

  • NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?

    abstract::We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, th...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(01)00475-1

    authors: Bracci-Laudiero L,Aloe L,Buanne P,Finn A,Stenfors C,Vigneti E,Theodorsson E,Lundeberg T

    更新日期:2002-02-01 00:00:00

  • Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes.

    abstract::The effect of interleukin-17 (IL-17) on production of nitric oxide (NO) in rodent astrocytes was investigated. While IL-17 by itself did not induce NO production, it caused a dose-dependent enhancement of IFN-gamma-triggered NO synthesis in both mouse and rat primary astrocytes. In contrast, IL-17 was unable to stimul...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(01)00391-5

    authors: Trajkovic V,Stosic-Grujicic S,Samardzic T,Markovic M,Miljkovic D,Ramic Z,Mostarica Stojkovic M

    更新日期:2001-10-01 00:00:00

  • Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica.

    abstract::We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, mac...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2017.10.001

    authors: Akaishi T,Kaneko K,Himori N,Takeshita T,Takahashi T,Nakazawa T,Aoki M,Nakashima I

    更新日期:2017-12-15 00:00:00

  • Enhancement of antigen-specific T-cell reactivity on the affected side in stroke patients.

    abstract::We have analyzed the impact of stroke with subsequent hemiparesis and sensory loss on in vivo mediated immune functions. The delayed-type hypersensitivity (DTH) reaction to purified protein derivate (PPD, tuberculin) was used as a measure of antigen-specific T-cell reactivity, and subcutaneous immunization with influe...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(91)90099-s

    authors: Tarkowski E,Ekelund P,Tarkowski A

    更新日期:1991-10-01 00:00:00