Abstract:
:G-protein-coupled receptors (GPCR) play an important role in inflammation. Their responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and beta-arrestins. We show here that induction of experimental autoimmune encephalomyelitis (EAE) by myelin oligodendrocyte glycoprotein (MOG) resulted in a profound decrease in GRK2 and GRK6 protein in splenocytes during all phases of disease. GRK2 mRNA was also lower during EAE, although the decrease in mRNA was less pronounced than the decrease in GRK2 protein. Interestingly, beta-arrestin protein expression was significantly increased. Downregulation of GRK2 was restricted to the spleen and mesenteric lymph nodes and was not observed in peritoneal macrophages. Furthermore, EAE did not induce alterations in GRK2 expression in heart, liver and pituitary.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Vroon A,Lombardi MS,Kavelaars A,Heijnen CJdoi
10.1016/s0165-5728(03)00050-xsubject
Has Abstractpub_date
2003-04-01 00:00:00pages
79-86issue
1-2eissn
0165-5728issn
1872-8421pii
S016557280300050Xjournal_volume
137pub_type
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更新日期:2016-04-15 00:00:00
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doi:10.1016/0165-5728(81)90024-2
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doi:10.1016/s0165-5728(99)00031-4
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-12-15 00:00:00
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