Immunoglobulin G(1) immune complex upregulates interferon-γ-induced nitric oxide production via ERK1/2 activation in murine microglia.

abstract：:Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the c...

journal_title：Journal of neuroimmunology

authors： Dörries R,Watanabe R,Wege H,ter Meulen V

更新日期：1987-04-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) establishes a persistent infection in the central nervous system (CNS). To examine the role of type I interferon (IFN-I)-mediated signals in TMEV infection, mice lacking a subunit of the type I IFN receptor (IFN-IR KO mice) were utilized. In contrast to wild type mice, I...

journal_title：Journal of neuroimmunology

authors： Jin YH,Hou W,Kim SJ,Fuller AC,Kang B,Goings G,Miller SD,Kim BS

更新日期：2010-09-14 00:00:00

abstract：:Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

journal_title：Journal of neuroimmunology

authors： Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

更新日期：2009-05-29 00:00:00

abstract：:Tissue cysts, the hallmark of chronic Toxoplasma gondii infection, are predominantly located in the brain making clearance of the parasite difficult. Currently available anti-T. gondii drugs are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. We examined whether abrogation of inhibitory ...

journal_title：Journal of neuroimmunology

authors： Xiao J,Li Y,Yolken RH,Viscidi RP

更新日期：2018-06-15 00:00:00

abstract：:We studied the effect of acute (1 h) or chronic exposure (7 and 14 days) to delta9-tetrahydrocannabinol (delta9-THC) on immune parameters in male Swiss mice. One hour after a dose of 10 mg/kg s.c., the splenocyte proliferative response to ConA and NK activity were not inhibited, but there was a significant decrease in...

journal_title：Journal of neuroimmunology

authors： Massi P,Sacerdote P,Ponti W,Fuzio D,Manfredi B,Viganó D,Rubino T,Bardotti M,Parolaro D

更新日期：1998-12-01 00:00:00

abstract：:The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in multiple sclerosis (MS) is poorly understood. We have recently reported that levels of tumor necrosis factor-alpha (TNF-alpha) correlate with blood-brain barrier damage in patients with active MS. Stimulation of endothelial ...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Noori MA,Ciardi M,Cirelli A,Thompson EJ

更新日期：1993-03-01 00:00:00

abstract：:In addition to a clear genetic disposition, environmental factors and viral infections are thought to play a role in the pathogenesis of autoimmune diseases such as type I diabetes or multiple sclerosis (MS). This article will explore, by use of paradigms developed in a transgenic mouse model, why it has been so diffi...

journal_title：Journal of neuroimmunology

authors： von Herrath MG

更新日期：2000-07-24 00:00:00

abstract：:Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

journal_title：Journal of neuroimmunology

authors： Vandevelde M,Zurbriggen A,Steck A,Bichsel P

更新日期：1986-03-01 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barré syndrome (GBS). Intravenous immunoglobulins (IVIg) are an effective treatment for GBS, but their mechanism of action is not well understood. Here we tested whether IVIg treatment, a potent modulator of proinflammatory assaults, reduces inflam...

journal_title：Journal of neuroimmunology

authors： Enders U,Toyka KV,Hartung HP,Gold R

更新日期：1997-06-01 00:00:00

abstract：:Patients with multiple sclerosis (MS) show a high prevalence of myelin-reactive CD8+ and CD4+ T-cell responses, which are the putative effectors/modulators of CNS neuropathology. Utilizing a novel combination of short-term culture, CFSE-based sorting and anchored PCR, we evaluated clonal compositions of neuroantigen-t...

journal_title：Journal of neuroimmunology

authors： Biegler BW,Yan SX,Ortega SB,Tennakoon DK,Racke MK,Karandikar NJ

更新日期：2011-05-01 00:00:00

abstract：:In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the...

journal_title：Journal of neuroimmunology

authors： Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S

更新日期：2014-07-15 00:00:00

abstract：:Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two pat...

journal_title：Journal of neuroimmunology

authors： Maddison P,Sadalage G,Ambrose PA,Jacob S,Vincent A

更新日期：2019-07-15 00:00:00

abstract：:Some age-related changes in immune function may be due, at least in part, to a disturbance in the communication between the nervous and immune systems. In the present work, the effects in vitro of neuropeptide Y (NPY) (10(-13) to 10(-7) M) on different peritoneal macrophage functions (adherence to substrate, chemotaxi...

journal_title：Journal of neuroimmunology

authors： De la Fuente M,Del Río M,Medina S

更新日期：2001-06-01 00:00:00

abstract：:A new technique for a conglutinin ELISA using a microtiter plate has been developed for measuring circulating immune complexes. The sensitivity of our system ranges between 0.2 and 3.2 micrograms equivalents of aggregated human IgG. We have applied this system to 21 normal healthy controls and 80 neurological patients...

journal_title：Journal of neuroimmunology

authors： Araga S,Irie H,Takahashi K

更新日期：1984-06-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with myelin basic protein (MBP) and adjuvants. Rats were treated with second daily injections of saline or cyclosporin A (CsA) from the day of inoculation. Saline-treated rats had an acute episode of disease followed by clinical r...

journal_title：Journal of neuroimmunology

authors： McCombe PA,Harness J,Pender MP

更新日期：1999-06-01 00:00:00

abstract：:To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid ...

journal_title：Journal of neuroimmunology

authors： van der Flier M,Coenjaerts FE,Mwinzi PN,Rijkers E,Ruyken M,Scharringa J,Kimpen JL,Hoepelman AI,Geelen SP

更新日期：2005-03-01 00:00:00

abstract：:Human G-protein-coupled formyl peptide receptor-like 1 and its mouse homologue formyl peptide receptor 2 mediate the chemotactic activity of a variety of pathogen and host-derived peptides, including amyloid beta(42), a key causative factor in Alzheimer's disease (AD).Here, we found that polyinosine-polycytidylic acid...

journal_title：Journal of neuroimmunology

authors： Chen K,Huang J,Liu Y,Gong W,Cui Y,Wang JM

更新日期：2009-08-18 00:00:00

abstract：:Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 as...

journal_title：Journal of neuroimmunology

authors： Yuhas Y,Ashkenazi S,Berent E,Weizman A

更新日期：2017-04-15 00:00:00

abstract：:The capacity of three different human glioblastoma cell lines to activate human T cells was analysed by measuring major histocompatibility complex (MHC) antigen expression, monokine secretion and lectin, mAb OKT3 and antigen-driven T cell proliferation. All glioblastoma cells tested were able to induce PHA and concana...

journal_title：Journal of neuroimmunology

authors： Däubener W,Zennati SS,Wernet P,Bilzer T,Fischer HG,Hadding U

更新日期：1992-11-01 00:00:00

abstract：:Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial evidence points to the involvement of genetic factors. We report on a genome-wide screen for disease association in the Hungarian population using 5532 microsatellite markers. These markers were typed in DNA pools that consisted ...

journal_title：Journal of neuroimmunology

authors： Rajda C,Bencsik K,Seres E,Jonasdottir A,Foltynie T,Sawcer S,Benediktsson K,Fossdal R,Setakis E,Compston A,Vécsei L

更新日期：2003-10-01 00:00:00

abstract：:The experimental autoimmune encephalomyelitis (EAE) model is indispensable for autoimmunity research, but model-specific T cell dynamics are sparsely studied. We used next-generation immunosequencing across lymphoid organs, blood and spinal cord in response to immunization with myelin basic protein (MBP) to study T ce...

journal_title：Journal of neuroimmunology

authors： Schliffke S,Carambia A,Akyüz N,Thiele B,Herkel J,Binder M

更新日期：2019-07-15 00:00:00

abstract：:Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown. The level of plasma Chit activity positively correlates with Alzheimer's disea...

journal_title：Journal of neuroimmunology

authors： Sotgiu S,Musumeci S,Marconi S,Gini B,Bonetti B

更新日期：2008-06-15 00:00:00

abstract：:Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiph...

journal_title：Journal of neuroimmunology

authors： Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

更新日期：2020-04-15 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to dev...

journal_title：Journal of neuroimmunology

authors： Mendel I,Natarajan K,Ben-Nun A,Shevach EM

更新日期：2004-04-01 00:00:00

abstract：:Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared ...

journal_title：Journal of neuroimmunology

authors： Mutnal MB,Cheeran MC,Hu S,Little MR,Lokensgard JR

更新日期：2010-10-08 00:00:00

abstract：:Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

journal_title：Journal of neuroimmunology

authors： Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

更新日期：1999-11-01 00:00:00

abstract：:15% of myasthenia gravis (MG) patients do not have antibodies against the acetylcholine receptor (AChR). Some of these "seronegative" MG patients have antibodies against muscle specific kinase (MuSK), and many have a non-IgG factor that acutely inhibits AChR function in a muscle-like cell line, CN21. Here we show, usi...

journal_title：Journal of neuroimmunology

authors： Spreadbury I,Kishore U,Beeson D,Vincent A

更新日期：2005-05-01 00:00:00

abstract：:Synthetic peptides of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) were screened for their ability to induce experimental allergic encephalomyelitis (EAE) in ABH (H-2A(g7)) and SJL (H-2(s)) mice. The use of overlapping 16mer...

journal_title：Journal of neuroimmunology

authors： Morris-Downes MM,McCormack K,Baker D,Sivaprasad D,Natkunarajah J,Amor S

更新日期：2002-01-01 00:00:00

abstract：:Antigen presentation, a key mechanism in immune responses, involves two main signals: the first is provided by the engagement of a major histocompatibility complex (MHC), class I or class II, with their TCR receptor in lymphocytes, whereas the second demands the participation of different co-stimulatory molecules, suc...

journal_title：Journal of neuroimmunology

authors： Almolda B,González B,Castellano B

更新日期：2010-06-01 00:00:00