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Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM.

Abstract：

:Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the context of an intact BBB were never seen in the absence of intrathecal synthesis of virus-specific antibodies. Affinity-mediated immunoblot analysis revealed a broad pattern of virus-specific antibodies with embedded clusters of restricted heterogeneity, but no signs of oligoclonal Ig production carrying non-viral specificity. From these data it was concluded that BN rats do control the intracerebral spread of JHM virus effectively by a strong local virus-specific antibody response, thereby preventing a clinically apparent disease.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Dörries R,Watanabe R,Wege H,ter Meulen V

doi

10.1016/0165-5728(87)90017-8

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

305-16

issue

3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(87)90017-8

journal_volume

14

pub_type

杂志文章

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