Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy.


:The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after treatment with Cbl, transforming growth factor-beta1 or S-adenosyl-L-methionine, and the normal myelin ultrastructure of the spinal cord was concomitantly restored. The concomitance of the two beneficial effects of these treatments strongly suggests that the increases in CSF sCD40:sCD40L levels may participate in the pathogenesis of purely myelinolytic Cbl-D central neuropathy in the rat. In keeping with this, an anti-CD40 treatment prevented myelin lesions.


J Neuroimmunol


Veber D,Mutti E,Galmozzi E,Cedrola S,Galbiati S,Morabito A,Tredici G,La Porta CA,Scalabrino G




Has Abstract


2006-07-01 00:00:00














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    abstract::In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Van Ranst L,Lauweryns JM

    更新日期:1990-09-01 00:00:00

  • Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis.

    abstract::An epistatic gene interaction has been advocated to explain disease susceptibility in multiple sclerosis (MS). Cytokine genes are possible candidates due to the central role played by cytokines in the regulation of the immune-mediated pathogenetic process leading to central nervous system demyelination in these patien...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Vandenbroeck K,Martino G,Marrosu M,Consiglio A,Zaffaroni M,Vaccargiu S,Franciotta D,Ruggeri M,Comi G,Grimaldi LM

    更新日期:1997-06-01 00:00:00

  • Immunoglobulinfree light chains reduce in an antigen-specific manner the rate of rise of action potentials of mouse non-nociceptive dorsal root ganglion neurons.

    abstract::Plasma B cells secrete immunoglobulinfree light chains (IgLC) which by binding to mast cells can mediate hypersensitivity responses and are involved in several immunological disorders. To investigate the effects of antigen-specific IgLC activation, intracellular recordings were made from cultured murine dorsal root ga...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rijnierse A,Kraneveld AD,Salemi A,Zwaneveld S,Goumans AP,Rychter JW,Thio M,Redegeld FA,Westerink RH,Kroese AB

    更新日期:2013-11-15 00:00:00

  • Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis.

    abstract::G-protein-coupled receptors (GPCR) play an important role in inflammation. Their responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and beta-arrestins. We show here that induction of experimental autoimmune encephalomyelitis (EAE) by myelin oligodendrocyte glycoprotein (MOG) resulted in a profoun...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Vroon A,Lombardi MS,Kavelaars A,Heijnen CJ

    更新日期:2003-04-01 00:00:00

  • Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus.

    abstract::The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Zivković IP,Rakin AK,Petrović-Djergović DM,Kosec DJ,Mićić MV

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  • Central nervous system infection and immune response in mice inoculated into the lip with herpes simplex virus type 1.

    abstract::Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski H

    更新日期:1982-06-01 00:00:00

  • Differential induction of interleukin-I beta mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides.

    abstract::The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and cho...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Tonelli LH,Maeda S,Rapp KL,Sternberg EM

    更新日期:2003-07-01 00:00:00

  • Interleukin-1 activity in lesioned peripheral nerve.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rotshenker S,Aamar S,Barak V

    更新日期:1992-07-01 00:00:00

  • Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice.

    abstract::Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduc...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sun Y,Tian T,Gao J,Liu X,Hou H,Cao R,Li B,Quan M,Guo L

    更新日期:2016-03-15 00:00:00

  • Evidence for genetic contamination of inbred buffalo rats (RT-1b) obtained from a commercial vendor.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Jones RE,Weinberg A,Bourdette D

    更新日期:1994-07-01 00:00:00

  • Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis.

    abstract::In the present study, we investigated the B-cell translocation gene 1 (BTG1) as a candidate for multiple sclerosis (MS) susceptibility. BTG1 is a member of a family of genes involved in the apoptotic process. We genotyped two SNPs of the BTG1 gene (rs731652 and rs12694) in 550 MS patients and 548 controls. For SNP rs7...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Camiña-Tato M,Morcillo-Suárez C,Navarro A,Fernández M,Horga A,Montalban X,Comabella M

    更新日期:2009-08-18 00:00:00

  • Immunogenetic markers in chlorpromazine-induced tardive dyskinesia.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


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  • IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity.

    abstract::Immunization with the whole cell pertussis vaccine (Pw), but not the acellular pertussis vaccine (Pa), is associated with a number of neurological side effects. Previously, we have demonstrated a role for interleukin-1beta (IL-1beta) in Pw reactogenicity. Here we report that parenteral Pw administration resulted in a ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Armstrong ME,Loscher CE,Lynch MA,Mills KH

    更新日期:2003-03-01 00:00:00

  • Age-associated alterations in the time-dependent profile of pro- and anti-inflammatory proteins within the hippocampus in response to acute exposure to interleukin-1β.

    abstract::The pro-inflammatory cytokine IL-1β is known to play a role in several models of aging, neuroinflammation, and neurodegenerative diseases. Here, we document a detailed time- and age-dependent pattern of pro- and anti-inflammatory biomarkers following bilateral intrahippocampal injection of interleukin-1β. During the f...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


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  • T lymphocyte subset abnormalities in peripheral blood from patients with the Guillain-Barré syndrome.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Dahle C,Vrethem M,Ernerudh J

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  • Infection of mice with lactic dehydrogenase virus prevents development of experimental allergic encephalomyelitis.

    abstract::A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective in...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Inada T,Mims CA

    更新日期:1986-03-01 00:00:00

  • A monoclonal antibody recognizing subpopulations of neurones in mouse brain.

    abstract::A monoclonal antibody, designated C138, was raised against a particulate fraction from young postnatal mouse cerebellum. In sections from adult mouse brain and cerebellum, this antibody stained a sub-population of neurons. Cell bodies of large neurones and fibre tracts were negative in all brain regions examined, wher...

    journal_title:Journal of neuroimmunology

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  • Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system.

    abstract::Traumatic brain injury can lead to locally destructive secondary events mediated by several inflammatory components. Following lateral fluid-percussion (FP) brain injury in rats, we examined cortical and hippocampal sections for neutrophil infiltration and accumulation of complement component C3. Neutrophil influx int...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Keeling KL,Hicks RR,Mahesh J,Billings BB,Kotwal GJ

    更新日期:2000-06-01 00:00:00

  • Tumour necrosis factor-alpha has few morphological effects within the dorsal columns of the spinal cord, in contrast to its effects in the peripheral nervous system.

    abstract::There is circumstantial evidence implicating the pro-inflammatory cytokine tumour necrosis factor (TNF) in the pathogenesis of multiple sclerosis (MS), but there is no direct evidence that TNF can produce demyelination in the central nervous system (CNS). We demonstrate here that single injections of TNF into the dors...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Hall SM,Redford EJ,Smith KJ

    更新日期:2000-07-01 00:00:00

  • Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica.

    abstract::We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, mac...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Akaishi T,Kaneko K,Himori N,Takeshita T,Takahashi T,Nakazawa T,Aoki M,Nakashima I

    更新日期:2017-12-15 00:00:00

  • Delayed type skin response to myelin basic protein in chronic relapsing experimental allergic encephalomyelitis.

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    journal_title:Journal of neuroimmunology

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  • Endogenous spinal cord stem cells in multiple sclerosis and its animal model.

    abstract::The adult mammalian spinal cord (SC) harbors neural stem cells (NSCs). The SC-NSCs are mostly quiescent during physiological conditions but are quickly activated in traumatic injury models. The SC-NSCs generate mostly glia, but are able to differentiate into neurons when affected by favourable conditions. An example i...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Covacu R,Brundin L

    更新日期:2019-06-15 00:00:00

  • Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism.

    abstract::Microglia become activated immune cells during infection or disease in the central nervous system (CNS). However, the mechanisms that downregulate activated microglia to prevent immune-mediated damage are not completely understood. Vitamin D3 has been suggested to have immunomodulatory affects, and high levels of vita...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Boontanrart M,Hall SD,Spanier JA,Hayes CE,Olson JK

    更新日期:2016-03-15 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

    更新日期:2020-04-15 00:00:00

  • Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Strle K,McCusker RH,Tran L,King A,Johnson RW,Freund GG,Dantzer R,Kelley KW

    更新日期:2007-08-01 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Chen K,Huang J,Liu Y,Gong W,Cui Y,Wang JM

    更新日期:2009-08-18 00:00:00

  • Inhibition of T cell superantigen responses following treatment with the kappa-opioid agonist U50,488H.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Guan L,Eisenstein TK,Adler MW,Rogers TJ

    更新日期:1997-05-01 00:00:00

  • Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in astrocytes.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Shrikant P,Chung IY,Ballestas ME,Benveniste EN

    更新日期:1994-05-01 00:00:00

  • Human neutrophil and macrophage chemokinesis induced by cardiopulmonary bypass: loss of DAME and IL-1 chemotaxis.

    abstract::Cardiopulmonary bypass (CPB) induces both cellular immunosuppression and an inflammatory response. In an effort to better characterize CPB-induced immune dysfunction, we examined the chemotaxic ability of human granulocytes and macrophages to D-Ala2-Met-enkephalin (DAME) and interleukin (IL)-1 alpha with computer-assi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Stefano GB,Bilfinger TV

    更新日期:1993-09-01 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

    更新日期:2012-11-15 00:00:00