Impaired immune responsiveness is an essential component in persistent central nervous system infection with gross murine leukemia virus.

Abstract:

:Exposure of newborn mice to Gross murine leukemia virus (GMuLV) results in persistent viral infection of the central nervous system (CNS) white matter. Animals exposed to virus as neonates showed a marked depression in GMuLV-specific B lymphocyte function as evidenced by significant decreases in adult and neonatal anti-GMuLV antibody levels. Immunohistochemical analyses showed that the sites of GMuLV infection in the CNS were also devoid of major histocompatibility complex (MHC) class I and II protein expression, although transplantation of GMuLV-infected brain tissue to the kidney capsules of immunocompetent mice induced a potent mononuclear cell graft infiltrate. These results indicate that persistent GMuLV infection of the CNS is linked to both impairment of anti-GMuLV peripheral immune responses and deficient antigen-presenting cell function within the CNS.

journal_name

J Neuroimmunol

authors

Korostoff JM,Nakada MT,Markman JF,Gaulton GN

doi

10.1016/0165-5728(91)90093-m

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1-14

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165-5728(91)90093-M

journal_volume

34

pub_type

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