Impaired immune responsiveness is an essential component in persistent central nervous system infection with gross murine leukemia virus.


:Exposure of newborn mice to Gross murine leukemia virus (GMuLV) results in persistent viral infection of the central nervous system (CNS) white matter. Animals exposed to virus as neonates showed a marked depression in GMuLV-specific B lymphocyte function as evidenced by significant decreases in adult and neonatal anti-GMuLV antibody levels. Immunohistochemical analyses showed that the sites of GMuLV infection in the CNS were also devoid of major histocompatibility complex (MHC) class I and II protein expression, although transplantation of GMuLV-infected brain tissue to the kidney capsules of immunocompetent mice induced a potent mononuclear cell graft infiltrate. These results indicate that persistent GMuLV infection of the CNS is linked to both impairment of anti-GMuLV peripheral immune responses and deficient antigen-presenting cell function within the CNS.


J Neuroimmunol


Korostoff JM,Nakada MT,Markman JF,Gaulton GN




Has Abstract


1991-10-01 00:00:00














  • Major histocompatibility complex class II molecule expression on muscle cells is regulated by differentiation: implications for the immunopathogenesis of muscle autoimmune diseases.

    abstract::Major histocompatibility complex (MHC) class II molecules are expressed on myoblasts after interferon-gamma (IFN-gamma) treatment, suggesting a muscle cell involvement in antigen presentation in inflammatory myopathies. However, they were not observed on normal or pathological myofibers. This discrepancy might be rela...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mantegazza R,Gebbia M,Mora M,Barresi R,Bernasconi P,Baggi F,Cornelio F

    更新日期:1996-08-01 00:00:00

  • TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation.

    abstract::VCAM-1 is an adhesion molecule that is important to leukocyte movement across the blood-brain barrier and is involved in the formation of destructive CNS inflammatory lesions in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We examined VCAM-1 expression in the CNS of animals with passive...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gimenez MA,Sim JE,Russell JH

    更新日期:2004-06-01 00:00:00

  • Oral terbutaline differentially affects cytokine (IL-10, IL-12, TNF, IFNg) release in multiple sclerosis patients and controls.

    abstract::Administration of beta-receptor agonists alleviate experimental multiple sclerosis (MS) in animal models. In this study, we investigated the effects of terbutaline (5 mg) on IL-10, IL-12, IFN-gamma and TNF-alpha production in whole blood stimulation cultures. IL-10 and IL-12 production were significantly enhanced in c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Heesen C,Gold SM,Sondermann J,Tessmer W,Schulz KH

    更新日期:2002-11-01 00:00:00

  • The significance of anti-neuronal antibodies in Alzheimer's disease.

    abstract::Indirect immunofluorescence and cell-type-specific markers were used to determine whether antibodies directed against specific neural cell types were present in patients with Alzheimer's disease (AD), other neurological diseases (OND) and normal controls. Sera and cerebrospinal fluid (CSF) were tested on either frozen...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Watts H,Kennedy PG,Thomas M

    更新日期:1981-03-01 00:00:00

  • Reduction of the microglial cell number in rat primary glial cell cultures by exogenous addition of dibutyryl cyclic adenosine monophosphate.

    abstract::The present work examined the effects induced by dibutyryl cyclic adenosine monophosphate (dB-cAMP) on microglial cells in primary glial cell cultures from newborn rats. Microglial cells were identified by OX42 immunohistochemistry and nucleoside diphosphatase histochemistry. Double staining for astrocytes was carried...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Dalmau I,Castellano B,Pedersen EB,Finsen B,Zimmer J,González B

    更新日期:1996-11-01 00:00:00

  • Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment.

    abstract::HIV-associated cognitive neurological disorders (HAND) prevail in the antiretroviral therapy era. Proteomics analysis of CSF revealed expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) in Hispanic women with cognitive impairment (CI). We tested the hypothesis that there is reduced capacity of antioxidant enzymes in ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Velázquez I,Plaud M,Wojna V,Skolasky R,Laspiur JP,Meléndez LM

    更新日期:2009-01-03 00:00:00

  • Evidence for activation of the complement cascade in the hypoglossal nucleus following peripheral nerve injury.

    abstract::Following hypoglossal nerve transection in adult rats, immunoreactivity for complement factor C3 and one of its degradation products C3d as well as C4d and immunoglobulin G (IgG) was observed in the ipsilateral hypoglossal nucleus. Double-labelling experiments indicated that these antigens were present in perineuronal...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Svensson M,Aldskogius H

    更新日期:1992-09-01 00:00:00

  • Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids.

    abstract::To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-1 beta (IL-1 beta), IL-2, interferon-gam...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gallai V,Sarchielli P,Trequattrini A,Franceschini M,Floridi A,Firenze C,Alberti A,Di Benedetto D,Stragliotto E

    更新日期:1995-02-01 00:00:00

  • Ventral tegmental area-basolateral amygdala-nucleus accumbens shell neurocircuitry controls the expression of heroin-conditioned immunomodulation.

    abstract::The present investigations sought to determine whether the ventral tegmental area (VTA), basolateral amygdala (BLA), and nucleus accumbens shell (NAC) comprise a circuitry that mediates heroin-induced conditioned immunomodulation. Rats were given conditioning trials in which they received an injection of heroin upon p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Szczytkowski JL,Fuchs RA,Lysle DT

    更新日期:2011-08-15 00:00:00

  • Increase of matrix metalloproteinase-9 in peripheral blood of multiple sclerosis patients treated with high doses of methylprednisolone.

    abstract::Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

    更新日期:2004-01-01 00:00:00

  • Association of a CA repeat polymorphism upstream of the Fas ligand gene with multiple sclerosis.

    abstract::We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of M...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Zayas MD,Lucas M,Solano F,Fernández-Pérez MJ,Izquierdo G

    更新日期:2001-06-01 00:00:00

  • Type 1 immune response in progressive multiple sclerosis.

    abstract::The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Frisullo G,Plantone D,Marti A,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Batocchi AP

    更新日期:2012-08-15 00:00:00

  • A possible association between elevated serum levels of brain-specific auto-antibodies and reduced plasma levels of docosahexaenoic acid in autistic children.

    abstract::Polyunsaturated fatty acids (PUFAs) are not only essential for energy production, but they also exhibit a range of immunomodulatory properties that progress through T cell mediated events. Autoimmunity may have a pathogenic role in a subgroup of autistic children. This study is the first to investigate the relationshi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mostafa GA,El-Khashab HY,Al-Ayadhi LY

    更新日期:2015-03-15 00:00:00

  • Inhibition of Ras attenuates the course of experimental autoimmune neuritis.

    abstract::EAN induced in Lewis rats by immunization with peripheral bovine myelin was treated by the Ras inhibitor farnesylthiosalicylate (FTS). Treatment from day 0 with FTS (5 mg/kg intraperitoneally twice daily) attenuated peak clinical scores (mean+/-S.E., 2.5+/-0.5 compared to 4.1+/-0.5 in saline treated controls, p=0.018,...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kafri M,Kloog Y,Korczyn AD,Ferdman-Aronovich R,Drory V,Katzav A,Wirguin I,Chapman J

    更新日期:2005-11-01 00:00:00

  • Tumour necrosis factor-alpha polymorphism and secretion in myasthenia gravis.

    abstract::The mechanism behind the association between MHC genes and myasthenia gravis (MG) is not fully understood. In the present study we studied the associations with polymorphisms at HLA-DR3, HLA-B8 and TNF-alpha genes in Swedish patients and healthy individuals. The TNF-alpha-308 allele 2 was associated with female patien...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Huang DR,Pirskanen R,Matell G,Lefvert AK

    更新日期:1999-02-01 00:00:00

  • Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis.

    abstract::Resistance to experimental allergic encephalomyelitis (EAE) induction by homogenized myelin (MSCH) in complete Freund's adjuvant (CFA) and pertussigen (P) in SJL mice was seen 1 week after intravenous injection of PLP 139-151 coupled to spleen cells (PLP-ECDI-SP). Although this resistance could be transferred by splee...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Santambrogio L,Crisi GM,Leu J,Hochwald GM,Ryan T,Thorbecke GJ

    更新日期:1995-05-01 00:00:00

  • Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis.

    abstract::We examined immune function and changes in T cell populations over a 1-year period in a series of progressive multiple sclerosis (MS) patients treated with different regimens of cyclophosphamide/ACTH as part of the Northeast Multiple Sclerosis Treatment Group. Our studies were designed to determine the effect of diffe...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hafler DA,Orav J,Gertz R,Stazzone L,Weiner HL

    更新日期:1991-05-01 00:00:00

  • A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes.

    abstract::Astrocytes provide crucial support for neurons and their impairment by viruses or their interactions with anti-viral or autoimmune responses could contribute to neurological disease. We have developed a transgenic mouse model to assess lymphocyte-astrocyte interactions. The major histocompatibility complex (MHC) class...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rall GF,Mucke L,Nerenberg M,Oldstone MB

    更新日期:1994-06-01 00:00:00

  • Neuromyelitis optica: concepts in evolution.

    abstract::Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively the optic nerve and the spinal cord. It was previously considered to be a severe variant of multiple sclerosis (MS) due to the similar pathological features and its resemblance to optico-spinal, or Japanese, MS, typical of Asian populati...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Fazio R,Radaelli M,Furlan R

    更新日期:2011-02-01 00:00:00

  • A chemiluminescence assay to detect antibodies to brain surface antigens in human sera.

    abstract::A chemiluminescence assay was developed based on the interaction between antibodies binding to the surface of living brain cells in culture and macrophages. Such interaction leads to production of reactive oxygen radicals which can be measured by a chemiluminescence assay. This assay was used to detect anti brain anti...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Brügger M,Dayrell-Hart E,Meier C,Vandevelde M,Zurbriggen A

    更新日期:1994-01-01 00:00:00

  • Strain differences in sleep and other pathophysiological sequelae of influenza virus infection in naive and immunized mice.

    abstract::To characterize behavioral and physiological alterations induced by viral respiratory infection, C57BL/6 and BALB/c strains of mice were monitored for 2 days before and 4 days after intranasal inoculation with influenza virus. Both strains developed hypothermia, decrease locomotor activity, and decreased delta-wave am...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Toth LA,Rehg JE,Webster RG

    更新日期:1995-04-01 00:00:00

  • Influenza virus- and cytokine-immunoreactive cells in the murine olfactory and central autonomic nervous systems before and after illness onset.

    abstract::Influenza virus invades the olfactory bulb (OB) and enhances cytokine mRNAs therein at the time of illness onset. Here we show that viral antigen immunoreactivity co-localized with glial markers in the OB but could not be detected in other brain areas. Interleukin 1beta- and tumor necrosis factor alpha-immunoreactivit...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Leyva-Grado VH,Churchill L,Wu M,Williams TJ,Taishi P,Majde JA,Krueger JM

    更新日期:2009-06-25 00:00:00

  • Increased expression of mir-301a in PBMCs of patients with relapsing-remitting multiple sclerosis is associated with reduced NKRF and PIAS3 expression levels and disease activity.

    abstract::Most of the multiple sclerosis (MS) patients are initially diagnosed with relapsing remitting multiple sclerosis (RRMS). Th17 cells and macrophages have been shown to play critical roles in pathogenesis of MS and initiation of CNS tissue damage. MiR-301a have recently been exposed as an activator of STAT3 in Th17 cell...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Tavakolpour V,Shokri G,Naser Moghadasi A,Mozafari Nahavandi P,Hashemi M,Kouhkan F

    更新日期:2018-12-15 00:00:00

  • Infection of mice with lactic dehydrogenase virus prevents development of experimental allergic encephalomyelitis.

    abstract::A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective in...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Inada T,Mims CA

    更新日期:1986-03-01 00:00:00

  • Nerve growth factor antibody exacerbates neuropathological signs of experimental allergic encephalomyelitis in adult lewis rats.

    abstract::In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Micera A,Properzi F,Triaca V,Aloe L

    更新日期:2000-05-01 00:00:00

  • Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts.

    abstract::IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFalpha-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFalpha to...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Strle K,McCusker RH,Tran L,King A,Johnson RW,Freund GG,Dantzer R,Kelley KW

    更新日期:2007-08-01 00:00:00

  • Eicosanoid production by rat cerebral endothelial cells: stimulation by lipopolysaccharide, interleukin-1 and interleukin-6.

    abstract::The capacity of rat cerebral endothelial cells (RCEC) to form eicosanoids was determined after incubation with 14C-labelled arachidonic acid. Prostaglandin E2 (PGE2) was the main metabolite formed by RCEC and was responsible for 54% of the total amount of eicosanoids produced. In contrast, in primary cultures of rat a...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: de Vries HE,Hoogendoorn KH,van Dijk J,Zijlstra FJ,van Dam AM,Breimer DD,van Berkel TJ,de Boer AG,Kuiper J

    更新日期:1995-06-01 00:00:00

  • Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T-lymphocytes via alpha-mediated mechanisms.

    abstract::A 20 h continuous treatment of rats with catecholamines, using subcutaneously implantable retard tablets, had either no (adrenaline, isoproterenol, midodrine) or a slight (noradrenaline) suppressive effect on the in vitro responsiveness of peripheral blood T-lymphocytes. A marked suppression of the mitogen response en...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Felsner P,Hofer D,Rinner I,Mangge H,Gruber M,Korsatko W,Schauenstein K

    更新日期:1992-03-01 00:00:00

  • Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire.

    abstract::Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: McCue D,Ryan KR,Wraith DC,Anderton SM

    更新日期:2004-11-01 00:00:00

  • Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens.

    abstract::Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

    更新日期:2010-09-14 00:00:00