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Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.

Abstract：

:Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to GM1 or GD1a gangliosides were detected by enzyme linked immunosorbent-assay (ELISA) in plasmas from ANPA patients but not in controls. These data suggest that antibodies to GM1 and GD1a gangliosides may play a pathogenic role in the demyelinating and/or inflammatory processes characteristic of rabies vaccine-induced acute neurologic complications.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Laouini D,Kennou MF,Khoufi S,Dellagi K

doi

10.1016/s0165-5728(98)00153-2

subject

Has Abstract

pub_date

1998-11-02 00:00:00

pages

63-72

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(98)00153-2

journal_volume

91

pub_type

杂志文章

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