Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins.

abstract：:The human platelet serotonergic responses of aggregation and uptake were shown to be modulated by muramyl peptides. Muramyl dipeptide inhibited serotonin uptake in a temperature dependent and stereospecific manner. It also blocked the binding to platelets of [3H]imipramine, a well-known inhibitor of serotonin uptake. ...

journal_title：Journal of neuroimmunology

authors： Polanski M,Karnovsky ML

更新日期：1992-03-01 00:00:00

abstract：:We previously found increased microglial proliferation and pro-inflammatory cytokine release in infant mice compared to juvenile mice after hypoxia-ischemia (HI). The aim of the current study was to assess for differences in the effect of microglial suppression on HI-induced brain injury in infant and juvenile mice. H...

journal_title：Journal of neuroimmunology

authors： Cikla U,Chanana V,Kintner DB,Covert L,Dewall T,Waldman A,Rowley P,Cengiz P,Ferrazzano P

更新日期：2016-02-15 00:00:00

abstract：:A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...

journal_title：Journal of neuroimmunology

authors： Doll SC,Johnson TC

更新日期：1989-09-01 00:00:00

abstract：:Immunofluorescence, cell binding assays and enzyme immunoassays were used to investigate the expression of class II major histocompatibility antigens on peripheral blood monocytes in 67 patients with multiple sclerosis. Monocytes from patients with active disease expressed fewer HLA-DR molecules on their surface than ...

journal_title：Journal of neuroimmunology

authors： Baxevanis CN,Reclos GJ,Arsenis P,Anastasopoulos E,Katsiyiannis A,Lymberi P,Matikas N,Papamichail M

更新日期：1989-05-01 00:00:00

abstract：:The two chemokines, monocyte chemoattractant protein (MCP)-1 and gamma-interferon inducible protein (IP)-10, are thought to be involved in the pathogenesis of multiple sclerosis (MS). We measured MCP-1 and IP-10 levels in serum and CSF samples from 38 acute and 25 stable MS patients and from 40 controls. The latter co...

journal_title：Journal of neuroimmunology

authors： Franciotta D,Martino G,Zardini E,Furlan R,Bergamaschi R,Andreoni L,Cosi V

更新日期：2001-04-02 00:00:00

abstract：:In this study we have analysed the expression of mRNA encoding the m1-m5 mAChR subtypes in human blood mononuclear cells and subpopulations of lymphocytes using reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Total RNA was extracted from human blood mononuclear cells. T cells, monocytes. EB virus t...

journal_title：Journal of neuroimmunology

authors： Hellström-Lindahl E,Nordberg A

更新日期：1996-08-01 00:00:00

abstract：:Over the past decade, remarkable progress has been made in our understanding of the pathogenesis of Miller Fisher syndrome (MFS), a clinical variant of Guillain Barré syndrome (GBS). MFS comprises the clinical triad of ataxia, areflexia and ophthalmoplegia. It is associated with acute-phase IgG antibodies to GQ1b and ...

journal_title：Journal of neuroimmunology

authors： Willison HJ,O'Hanlon GM

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS:T...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Liu G,Duan Y,Han X,Dong H,Geng J

更新日期：2016-12-15 00:00:00

abstract：:In addition to a clear genetic disposition, environmental factors and viral infections are thought to play a role in the pathogenesis of autoimmune diseases such as type I diabetes or multiple sclerosis (MS). This article will explore, by use of paradigms developed in a transgenic mouse model, why it has been so diffi...

journal_title：Journal of neuroimmunology

authors： von Herrath MG

更新日期：2000-07-24 00:00:00

abstract：:We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate int...

journal_title：Journal of neuroimmunology

authors： Fabian RH,Hulsebosch CE

更新日期：1989-10-01 00:00:00

abstract：:The localization of dopamine stores and the expression and localization of vesicular monoamine transporter (VMAT) type-1 and 2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat thymus and spleen by immunohistochemical, immunochemical techniques and by RT-PCR. In the thymus dopamine immunor...

journal_title：Journal of neuroimmunology

authors： Mignini F,Tomassoni D,Traini E,Amenta F

更新日期：2009-01-03 00:00:00

abstract：:Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal nec...

journal_title：Journal of neuroimmunology

authors： Horváth E,Huțanu A,Chiriac L,Dobreanu M,Orădan A,Nagy EE

更新日期：2018-11-15 00:00:00

abstract：:Cells that produce tumor necrosis factor-alpha (TNF-alpha) require the presence of signaling molecules since this cytokine is not normally expressed in a constitutive manner. It has been demonstrated that glial cells can produce TNF-alpha; however, the specific inducing molecules and their mechanism(s) of action have ...

journal_title：Journal of neuroimmunology

authors： Bethea JR,Chung IY,Sparacio SM,Gillespie GY,Benveniste EN

更新日期：1992-02-01 00:00:00

abstract：:We describe here the methods by which enriched populations of oligodendrocytes were isolated from adult porcine brains using Percoll density gradient centrifugation and their immunological properties analyzed by a fluorescence-activated cell sorter (FACS). The analyses by immunofluorescence microscopy and FACS indicat...

journal_title：Journal of neuroimmunology

authors： Smyrnis E,Kim SU,Kim MW,Oger J,Sylvester C,Paty DW

更新日期：1986-11-01 00:00:00

abstract：:A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective in...

journal_title：Journal of neuroimmunology

authors： Inada T,Mims CA

更新日期：1986-03-01 00:00:00

abstract：:To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid ...

journal_title：Journal of neuroimmunology

authors： van der Flier M,Coenjaerts FE,Mwinzi PN,Rijkers E,Ruyken M,Scharringa J,Kimpen JL,Hoepelman AI,Geelen SP

更新日期：2005-03-01 00:00:00

abstract：:Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neur...

journal_title：Journal of neuroimmunology

authors： Guasp M,Solà-Valls N,Martínez-Hernández E,Gil MP,González C,Brieva L,Saiz A,Dalmau J,Graus F,Ariño H

更新日期：2016-11-15 00:00:00

abstract：:Naive Th cells obtained from OVA(323-339)-specific DO11.10 TCR-Tg mice did not express preproenkephalin (PPE) mRNA. However, culture of naive Th cells with OVA(323-339) peptide (OVA-pep) plus IL-2 under Th2-inducing conditions for 7 days resulted in an induction of PPE mRNA. The PPE mRNA was also induced by culturing ...

journal_title：Journal of neuroimmunology

authors： Yahata T,Yahata C,Ohta A,Sekimoto M,Kitamura H,Iwakabe K,Habu S,Azuma S,Nakui M,Sato M,Koda T,Nishimura T

更新日期：2000-06-26 00:00:00

abstract：:Sudden hearing loss may occur in rare cases of relapsing-remitting multiple sclerosis (RRMS). There have also been reports of idiopathic sudden sensorineural hearing loss (SNHL) in patients with neuromyelitis optica spectrum disorders (NMOSD), but the frequency of such cases is unclear. We conducted a retrospective an...

journal_title：Journal of neuroimmunology

authors： Tanaka M,Tanaka K

更新日期：2016-09-15 00:00:00

abstract：:SJL/J mice were infected with a recombinant vaccinia virus encoding myelin proteolipid protein (PLP) (VVplp). Antibody responses to whole PLP and to encephalitogenic peptides, p139-151, p178-191 or p104-117 were measured after vaccination and following challenge with these three PLP peptides. Competitive ELISAs showed...

journal_title：Journal of neuroimmunology

authors： Wang LY,Fujinami RS

更新日期：1997-05-01 00:00:00

abstract：:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or ...

journal_title：Journal of neuroimmunology

authors： Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

更新日期：2010-09-14 00:00:00

abstract：:CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Inv...

journal_title：Journal of neuroimmunology

authors： Jung C,Stoeckle C,Wiesmüller KH,Laub R,Emmrich F,Jung G,Melms A

更新日期：2008-09-15 00:00:00

abstract：:Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T ...

journal_title：Journal of neuroimmunology

authors： Kumar MM,Venkataswamy MM,Sathyanarayanan G,Thippeswamy H,Chandra PS,Mani RS

更新日期：2017-09-15 00:00:00

abstract：:Although it is generally accepted that pro-inflammatory cytokines produced by cells of the central nervous system play important roles in the communication between the central nervous system and the immune system during sepsis, it is not clear whether these cytokines are produced in the brain under subseptic condition...

journal_title：Journal of neuroimmunology

authors： Quan N,Stern EL,Whiteside MB,Herkenham M

更新日期：1999-01-01 00:00:00

abstract：:Th17 cells play an important role in multiple sclerosis (MS) and its autoimmune model, experimental autoimmune encephalomyelitis (EAE). However, studies have not addressed how enhanced Th17 immune responses can affect demyelinating diseases. We induced EAE with MOG in RORγt transgenic C57BL/6 mice that overexpress a T...

journal_title：Journal of neuroimmunology

authors： Martinez NE,Sato F,Omura S,Kawai E,Takahashi S,Yoh K,Tsunoda I

更新日期：2014-11-15 00:00:00

abstract：:M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differe...

journal_title：Journal of neuroimmunology

authors： Michelucci A,Heurtaux T,Grandbarbe L,Morga E,Heuschling P

更新日期：2009-05-29 00:00:00

abstract：:We investigated whether microglia form gap junctions with themselves, or with astrocytes, oligodendrocytes, or neurons in vivo in normal mouse brains, and in pathological conditions that induce microglial activation - brain injury and a model of Alzheimer's disease. Although microglia are in close physical proximity t...

journal_title：Journal of neuroimmunology

authors： Wasseff SK,Scherer SS

更新日期：2014-04-15 00:00:00

abstract：:Some age-related changes in immune function may be due, at least in part, to a disturbance in the communication between the nervous and immune systems. In the present work, the effects in vitro of neuropeptide Y (NPY) (10(-13) to 10(-7) M) on different peritoneal macrophage functions (adherence to substrate, chemotaxi...

journal_title：Journal of neuroimmunology

authors： De la Fuente M,Del Río M,Medina S

更新日期：2001-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune demyelinating disease of the central nervous system (CNS). This study investigated whether expression and activity of the calcium-activated protease calpain correlated with Th1/Th2 dysregulation in MS patients during states of relapse and remission. Calpain expressio...

journal_title：Journal of neuroimmunology

authors： Imam SA,Guyton MK,Haque A,Vandenbark A,Tyor WR,Ray SK,Banik NL

更新日期：2007-10-01 00:00:00

abstract：:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

journal_title：Journal of neuroimmunology

authors： Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

更新日期：2006-08-01 00:00:00