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Beta-endorphin alters a viral induced central nervous system disease in normal mice but not in nude mice.

Abstract：

:A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS5 VSV, 70% of the animals died within 8 days of infection. In comparison, less than 10% of the animals had died after 21 days when infected with tsG31-KS5 VSV alone. When mice were injected with beta-endorphin and tsG31-KS5 VSV simultaneously, or with beta-endorphin 21 days after infection, the more aggressive clinical disease was not observed. Superficially, the more lethal disease induced by beta-endorphin appeared to be a result of a mild hypothermia caused by the neuropeptide. beta-Endorphin, however, did not influence the disease in nude (nu/nu) mice even though their core temperatures were reduced to an extent similar to that of BALB/c (+/+) mice, implicating the involvement of T lymphocytes in the alteration of the course of infection in normal mice.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Doll SC,Johnson TC

doi

10.1016/0165-5728(89)90097-0

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

47-53

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(89)90097-0

journal_volume

24

pub_type

杂志文章

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