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Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis.

Abstract：

:CD4+CD25+ regulatory T cells (Treg) transform the HIV-1 infected macrophage from a neurotoxic to a neuroprotective phenotype. This was demonstrated previously in a murine model of HIV-1 encephalitis induced by intracranial injection of HIV-1/vesicular stomatitis virus-infected bone marrow macrophages. In this report, relationships between Treg ingress of end organ tissues, notably the brain, and neuroprotection were investigated. Treg from EGFP-transgenic donor mice were expanded, labeled with indium-111, and adoptively transferred. Treg distribution was assayed by single photon emission computed tomography and immunohistochemistry. Treg readily migrated across the blood brain barrier and were retained within virus-induced neuroinflammatory sites. In non-inflamed peripheral tissues (liver and spleen) Treg were depleted. These observations demonstrate that Treg migrate to sites of inflammation where they modulate immune responses.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Gong N,Liu J,Reynolds AD,Gorantla S,Mosley RL,Gendelman HE

doi

10.1016/j.jneuroim.2010.08.014

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

33-41

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00378-4

journal_volume

230

pub_type

杂志文章

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