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Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate.

Abstract：

:Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which is much closer to the in vivo situation than dissociated cell culture. We observed dose-dependent TRAIL-mediated death of both total human CNS cells and neurons, which was prevented by flupirtine-maleate, a centrally acting analgesic drug with proposed neuroprotective properties. Our data suggest flupirtine-maleate as an orally available neuroprotective approach in the course of neuroinflammation.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Dörr J,Roth K,Zurbuchen U,Deisz R,Bechmann I,Lehmann TN,Meier S,Nitsch R,Zipp F

doi

10.1016/j.jneuroim.2005.06.027

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

204-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00273-0

journal_volume

167

pub_type

杂志文章

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