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Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes.

Abstract：

:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including MSH genes and RAD53, were observed. GADD45g, a gene responsible for regulating cell cycle arrest and apoptosis, was significantly induced; as was Pura, a gene involved in cell proliferation. These data suggest that, at the molecular level, stress activates genes responsible for priming the T cell to either undergo apoptosis or proliferation.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

doi

10.1016/j.jneuroim.2005.06.012

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

34-44

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00258-4

journal_volume

167

pub_type

杂志文章

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