Methylene blue alleviates experimental autoimmune encephalomyelitis by modulating AMPK/SIRT1 signaling pathway and Th17/Treg immune response.

abstract：:Chemokines are critical mediators of immune cell entry into the central nervous system (CNS), as occurs in neuroinflammatory disease such as multiple sclerosis. Chemokines are also implicated in the immune response to viral infections. Many viruses encode proteins that mimic or block chemokine actions, in order to eva...

journal_title：Journal of neuroimmunology

authors： Millward JM,Holst PJ,Høgh-Petersen M,Thomsen AR,Christensen JP,Owens T

更新日期：2010-07-27 00:00:00

abstract：:Humoral and cell-mediated immune responses of inbred BALB/c male mice were assayed for differential reactivities associated with behavioral sidedness, which was evaluated by spontaneous rotational behavior in a circular cage model system. Mice with left-turning preference had lower in vivo primary IgM and IgG anti-Key...

journal_title：Journal of neuroimmunology

authors： Kim D,Carlson JN,Seegal RF,Lawrence DA

更新日期：1999-01-01 00:00:00

abstract：:Exposure of newborn mice to Gross murine leukemia virus (GMuLV) results in persistent viral infection of the central nervous system (CNS) white matter. Animals exposed to virus as neonates showed a marked depression in GMuLV-specific B lymphocyte function as evidenced by significant decreases in adult and neonatal ant...

journal_title：Journal of neuroimmunology

authors： Korostoff JM,Nakada MT,Markman JF,Gaulton GN

更新日期：1991-10-01 00:00:00

abstract：:The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...

journal_title：Journal of neuroimmunology

authors： Frisullo G,Plantone D,Marti A,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Batocchi AP

更新日期：2012-08-15 00:00:00

abstract：:Increases in spontaneous sister chromatid exchange (SCE) and gamma radiation-induced chromosome aberrations have been reported in peripheral blood lymphocytes (PBL) from multiple sclerosis (MS) patients, suggesting the presence of an abnormality in repair in this disease. We tested this hypothesis by measuring the abi...

journal_title：Journal of neuroimmunology

authors： Sola P,Merelli E,Faglioni P,Monti D,Cossarizza A,Franceschi C

更新日期：1989-01-01 00:00:00

abstract：:The hormone 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) has immune modulatory activities in vitro and in vivo, and can prevent or delay the onset of experimental or spontaneous autoimmune diseases. At therapeutical doses, however, hypercalcemic side effects are found. The present experiments examined the effects of ...

journal_title：Journal of neuroimmunology

authors： Branisteanu DD,Waer M,Sobis H,Marcelis S,Vandeputte M,Bouillon R

更新日期：1995-09-01 00:00:00

abstract：:SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot of chick retinal proteins at 21 days after intravitreal injection with 5 or 10 microM/eye Glu showed decreases in 37, 42, 53 and 57 kDa proteins and increases in 35, 72 and >94 kDa proteins. These proteins were carboxylases except for the 35 and 37 kDa...

journal_title：Journal of neuroimmunology

authors： Sattayasai N,Sattayasai J,Daduang S,Chahomchuen T,Ketkaew S,Puchongkavarin H

更新日期：2003-08-01 00:00:00

abstract：:Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-asso...

journal_title：Journal of neuroimmunology

authors： Puttini S,Panaite PA,Mermod N,Renaud S,Steck AJ,Kuntzer T

更新日期：2014-05-15 00:00:00

abstract：:We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all su...

journal_title：Journal of neuroimmunology

authors： Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

更新日期：2017-09-15 00:00:00

abstract：:A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...

journal_title：Journal of neuroimmunology

authors： Doll SC,Johnson TC

更新日期：1989-09-01 00:00:00

abstract：:The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing...

journal_title：Journal of neuroimmunology

authors： Karandikar NJ,Vanderlugt CL,Bluestone JA,Miller SD

更新日期：1998-08-14 00:00:00

abstract：:Guinea pigs inoculated with bovine spinal cord ventral horn homogenate develop a syndrome termed experimental autoimmune gray matter disease (EAGMD) characterized by extremity weakness, bulbar signs, and a loss of lower and upper motoneurons. To provide evidence for the role of autoimmune mechanisms, we have administe...

journal_title：Journal of neuroimmunology

authors： Tajti J,Stefani E,Appel SH

更新日期：1991-11-01 00:00:00

abstract：:Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytokines: G-CSF, IL1-α, ...

journal_title：Journal of neuroimmunology

authors： Hilliard A,Mendonca P,Soliman KFA

更新日期：2020-08-15 00:00:00

abstract：:The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) monocytes and B-lymphoc...

journal_title：Journal of neuroimmunology

authors： Windhagen A,Maniak S,Gebert A,Ferger I,Heidenreich F

更新日期：1999-04-01 00:00:00

abstract：:Hemokinin 1 is encoded by preprotachykinin C (PPT-C) mRNA, and has been proposed as a regulator of B and T cell lymphopoiesis. Here we demonstrate the expression of mouse PPT-C mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. Expression was detected in freshly isolated CD11...

journal_title：Journal of neuroimmunology

authors： Nelson DA,Marriott I,Bost KL

更新日期：2004-10-01 00:00:00

abstract：:In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial ...

journal_title：Journal of neuroimmunology

authors： Gallo P,Pagni S,Giometto B,Piccinno MG,Bozza F,Argentiero V,Tavolato B

更新日期：1990-09-01 00:00:00

abstract：:Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of i...

journal_title：Journal of neuroimmunology

authors： Alrouji M,Manouchehrinia A,Gran B,Constantinescu CS

更新日期：2019-04-15 00:00:00

abstract：:Interleukin-10 is a potent immunomodulatory cytokine with possible implications for the pathogenesis of multiple sclerosis. Increased IL10 mRNA expression is associated with stable disease. The interleukin 10 gene is highly polymorphic and certain haplotypes result in differential interleukin-10 expression. The presen...

journal_title：Journal of neuroimmunology

authors： Mäurer M,Kruse N,Giess R,Toyka KV,Rieckmann P

更新日期：2000-04-03 00:00:00

abstract：:Demyelination, a pathological hallmark of multiple sclerosis, may be a necessary but not a sufficient condition for motor dysfunction associated with this disease. We favor a neurodegenerative model of multiple sclerosis and suggest that demyelination creates a permissive environment wherein the denuded axon becomes s...

journal_title：Journal of neuroimmunology

authors： Howe CL,Ure D,Adelson JD,LaFrance-Corey R,Johnson A,Rodriguez M

更新日期：2007-08-01 00:00:00

abstract：:The experimental infection of immunocompetent and immunodeficient athymic mice with an avirulent encephalitogenic Toxoplasma strain (DX strain) was employed to study the ensuing encephalitic process by use of histological and immunocytochemical methods. In the acute phase of the infection Toxoplasma cysts and tachyzoi...

journal_title：Journal of neuroimmunology

authors： Schlüter D,Löhler J,Deckert M,Hof H,Schwendemann G

更新日期：1991-03-01 00:00:00

abstract：:We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese. DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 ...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Niino M,Ochi H,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2004-05-01 00:00:00

abstract：:Immunological events occurring in the central nervous system (CNS) as a result of head trauma are largely unexplored. We report here that the levels of the alternative pathway complement proteins C3 and factor B are elevated in the cerebrospinal fluid (CSF) of head-injured patients. C3 and factor B indices suggest tha...

journal_title：Journal of neuroimmunology

authors： Kossmann T,Stahel PF,Morganti-Kossmann MC,Jones JL,Barnum SR

更新日期：1997-03-01 00:00:00

abstract：:A new technique for a conglutinin ELISA using a microtiter plate has been developed for measuring circulating immune complexes. The sensitivity of our system ranges between 0.2 and 3.2 micrograms equivalents of aggregated human IgG. We have applied this system to 21 normal healthy controls and 80 neurological patients...

journal_title：Journal of neuroimmunology

authors： Araga S,Irie H,Takahashi K

更新日期：1984-06-01 00:00:00

abstract：:The concentrations of beta-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, beta-endorphin concentrations in mononuclear cells, increased aft...

journal_title：Journal of neuroimmunology

authors： Sacerdote P,Rubboli F,Locatelli L,Ciciliato I,Mantegazza P,Panerai AE

更新日期：1991-04-01 00:00:00

abstract：:Opioid-containing immunocytes migrate to inflamed sites where they release beta-endorphin which activates peripheral opioid receptors and produces analgesia. The immigration of immunocytes to sites of inflammation is mediated by adhesion molecules. In this study, the expression of L-, P-, E-selectin and platelet-endot...

journal_title：Journal of neuroimmunology

authors： Mousa SA,Machelska H,Schäfer M,Stein C

更新日期：2000-08-01 00:00:00

abstract：:Opioids have been hypothesized to suppress parameters of immune function by acting within the central nervous system to increase the activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Production of catecholamines and adrenocorticoids have been demonstrated to be responsible for man...

journal_title：Journal of neuroimmunology

authors： Hall DM,Suo JL,Weber RJ

更新日期：1998-03-15 00:00:00

abstract：:Neuronal apoptosis has recently been implicated in multiple sclerosis (MS). Apoptotic cell death of neurons is induced in cultures exposed to cerebrospinal fluid (CSF) from MS patients. Since caspases are essential in the regulation of apoptosis, direct evidence was sought linking caspases to CSF-induced neuronal deat...

journal_title：Journal of neuroimmunology

authors： Cid C,Alvarez-Cermeño JC,Regidor I,Plaza J,Salinas M,Alcázar A

更新日期：2003-03-01 00:00:00

abstract：:Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patt...

journal_title：Journal of neuroimmunology

authors： Meehan GR,McGonigal R,Cunningham ME,Wang Y,Barrie JA,Halstead SK,Gourlay D,Yao D,Willison HJ

更新日期：2018-10-15 00:00:00

abstract：:We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

journal_title：Journal of neuroimmunology

authors： Stevens DB,Gould KE,Swanborg RH

更新日期：1994-04-01 00:00:00

abstract：:We have previously demonstrated that central administration of interleukin (IL)-1beta suppresses natural killer (NK) cell activity, impairs NK-mediated lung clearance of tumor cells, and enhances tumor colonization. The central pathways activated by IL-1beta are as yet unknown. Using an in vivo model of tumor coloniza...

journal_title：Journal of neuroimmunology

authors： Hodgson DM,Yirmiya R,Taylor AN

更新日期：2001-09-03 00:00:00