Differential immune responses in mice with left- and right-turning preference.

abstract：:The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulati...

journal_title：Journal of neuroimmunology

authors： Ekerfelt C,Ernerudh J,Forsberg P,Bergström S

更新日期：1998-08-14 00:00:00

abstract：:A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynaptic adrenergic sensitivity as well...

journal_title：Journal of neuroimmunology

authors： Nickola TJ,Ignatowski TA,Spengler RN

更新日期：2000-07-10 00:00:00

abstract：:Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very...

journal_title：Journal of neuroimmunology

authors： Kakoulidou M,Ahlberg R,Yi Q,Giscombe R,Pirskanen R,Lefvert AK

更新日期：2004-03-01 00:00:00

abstract：:The in vivo relationship of interleukin-2 (IL-2) to the local humoral immune response within the central nervous system (CNS) in patients with multiple sclerosis (MS) is hitherto largely unknown. Intrathecal levels of IL-2 and soluble IL-2 receptors (sIL-2R) were correlated to the local CNS synthesis of immunoglobulin...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Hentges R,Thompson EJ

更新日期：1991-04-01 00:00:00

abstract：:We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate int...

journal_title：Journal of neuroimmunology

authors： Fabian RH,Hulsebosch CE

更新日期：1989-10-01 00:00:00

abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

journal_title：Journal of neuroimmunology

authors： Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

更新日期：2012-11-15 00:00:00

abstract：:We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of M...

journal_title：Journal of neuroimmunology

authors： Zayas MD,Lucas M,Solano F,Fernández-Pérez MJ,Izquierdo G

更新日期：2001-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has well recognized effects on cerebral endothelial cells and, therefore, may mediate disruption of blood-brain barrier in patients with multiple sclerosis (MS). To evaluate the in vivo relationship of TNF-alpha to blood-brain barrier impairment in MS, levels of this cytokine in...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Thompson EJ

更新日期：1992-05-01 00:00:00

abstract：:Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren'...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Takahashi T,Fujihara K,Misu T,Abe M,Ishii T,Aoki M,Nakashima I

更新日期：2020-06-15 00:00:00

abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

journal_title：Journal of neuroimmunology

authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

更新日期：2016-01-15 00:00:00

abstract：:Over the past decade, remarkable progress has been made in our understanding of the pathogenesis of Miller Fisher syndrome (MFS), a clinical variant of Guillain Barré syndrome (GBS). MFS comprises the clinical triad of ataxia, areflexia and ophthalmoplegia. It is associated with acute-phase IgG antibodies to GQ1b and ...

journal_title：Journal of neuroimmunology

authors： Willison HJ,O'Hanlon GM

更新日期：1999-12-01 00:00:00

abstract：:Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent a...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Jalili F,Ouamara N,Zameer A,Cosentino G,Mayne M,Hayardeny L,Antel JP,Bar-Or A,John GR

更新日期：2010-10-08 00:00:00

abstract：:An important extrahepatic consequence of Hepatitis C is its adverse impact on the central nervous system and cognitive performance. We aimed to determine whether there is a significant relationship between selected neurotransmitters and cytokines and cognitive performance in patients with Chronic Hepatitis C before an...

journal_title：Journal of neuroimmunology

authors： Weinstein AA,Estep JM,de Avila L,Curry M,Golabi P,Escheik C,Birerdinc A,Stepanova M,Price JK,Gerber L,Younossi ZM

更新日期：2019-10-15 00:00:00

abstract：:Bi-directional interactions between the central nervous system (CNS) and immune system are demonstrated by the modification of immune function using behavioral conditioning. However, the mechanisms by which the CNS achieves conditioned immunomodulation are still in question. Here, we report that the immunosuppressive ...

journal_title：Journal of neuroimmunology

authors： Exton MS,von Hörsten S,Schult M,Vöge J,Strubel T,Donath S,Steinmüller C,Seeliger H,Nagel E,Westermann J,Schedlowski M

更新日期：1998-08-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) has been reported to be expressed in various inflammatory disorders including human T cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I-infected T-cells expressed high levels of MMP-9 via viral transactivator Tax mediated act...

journal_title：Journal of neuroimmunology

authors： Kodama D,Saito M,Matsumoto W,Sabouri AH,Izumo S,Arimura K,Usuku K,Bangham CR,Osame M

更新日期：2004-11-01 00:00:00

abstract：:In experimental autoimmune encephalomyelitis (EAE) and other neurodegenerative diseases, astrocytes play an important role in promoting or attenuating the inflammatory response through induction of different cytokines and growth factors. HuR plays a major role in regulating many of these factors by modulating RNA stab...

journal_title：Journal of neuroimmunology

authors： Wheeler C,Nabors LB,Barnum S,Yang X,Hu X,Schoeb TR,Chen D,Ardelt AA,King PH

更新日期：2012-05-15 00:00:00

abstract：:A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...

journal_title：Journal of neuroimmunology

authors： Doll SC,Johnson TC

更新日期：1989-09-01 00:00:00

abstract：:Lewis rats sensitized against peripheral nervous system antigens can be protected against experimental allergic neuritis (EAN) by the intraperitoneal injection of silica quartz dust. Two doses of 200 mg silica given 8 and 11 days post-inoculation (dpi) protected against the development of both clinical and pathologica...

journal_title：Journal of neuroimmunology

authors： Tansey FA,Brosnan CF

更新日期：1982-11-01 00:00:00

abstract：:Endogenous hypothalamic pro-inflammatory cytokines modulate the hypothalamic-pituitary-adrenal (HPA) axis responses. To investigate whether hypothalamic IL-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) are associated with differential inflammatory susceptibilities between Lewis (LEW/N) and Fischer (F344/N) ...

journal_title：Journal of neuroimmunology

authors： Wei R,Listwak SJ,Sternberg EM

更新日期：2003-02-01 00:00:00

abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

更新日期：2001-09-03 00:00:00

abstract：:Nogo-A is a protein associated with central nervous system (CNS) myelin thought to impair regenerative responses and to suppress sprouting and plastic changes of synaptic terminals. In this study, we report that serum IgM autoantibodies to the recombinant large N-terminal inhibitory domain of Nogo-A are a frequent fin...

journal_title：Journal of neuroimmunology

authors： Reindl M,Khantane S,Ehling R,Schanda K,Lutterotti A,Brinkhoff C,Oertle T,Schwab ME,Deisenhammer F,Berger T,Bandtlow CE

更新日期：2003-12-01 00:00:00

abstract：:Immune complexes isolated from sera of patients with multiple sclerosis (MS) were analyzed for their antigenic content. Immune complexes precipitated with polyethylene glycol were inoculated into rabbits. The antisera raised were shown to react to MS and normal brain antigens by crossed immunoelectrophoresis, ELISA an...

journal_title：Journal of neuroimmunology

authors： Friedman J,Buskirk D,Marino LJ Jr,Zabriskie JB

更新日期：1987-02-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T helper 1 (Th1) cell mediated demyelinating disease and the principal animal model for multiple sclerosis. Spinal cords from SJL mice primed with proteolipid protein peptide 139-151 (pPLP) expressed the chemokines RANTES, MCP-1, MIP-2, KC, MIP-1alpha, MIP-1beta, Mi...

journal_title：Journal of neuroimmunology

authors： Fischer FR,Santambrogio L,Luo Y,Berman MA,Hancock WW,Dorf ME

更新日期：2000-10-02 00:00:00

abstract：:Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The...

journal_title：Journal of neuroimmunology

authors： Bomstein Y,Marder JB,Vitner K,Smirnov I,Lisaey G,Butovsky O,Fulga V,Yoles E

更新日期：2003-09-01 00:00:00

abstract：:In the century and a half since multiple sclerosis (MS) was first recognized, the pathology of the condition has been defined with increasing detail. From the recognition and definition of MS as a clinical phenomenon, studies of the diseased brain tissue have progressed in a manner dependent on the science of the time...

journal_title：Journal of neuroimmunology

authors： Hickey WF

更新日期：1999-07-01 00:00:00

abstract：:Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by communication deficits, impaired social interactions, and restricted stereotypical behaviors. Several immune cells are associated with immune dysfunction in ASD; however, IL-31 has not been explored in ASD. This study aims to ...

journal_title：Journal of neuroimmunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alsaad AMS,Assiri MA,Al-Mazroua HA,Attia SM

更新日期：2020-12-15 00:00:00

abstract：:Plasma B cells secrete immunoglobulinfree light chains (IgLC) which by binding to mast cells can mediate hypersensitivity responses and are involved in several immunological disorders. To investigate the effects of antigen-specific IgLC activation, intracellular recordings were made from cultured murine dorsal root ga...

journal_title：Journal of neuroimmunology

authors： Rijnierse A,Kraneveld AD,Salemi A,Zwaneveld S,Goumans AP,Rychter JW,Thio M,Redegeld FA,Westerink RH,Kroese AB

更新日期：2013-11-15 00:00:00

abstract：:Interleukin (IL)-10 is an anti-inflammatory cytokine that can down-regulate various aspects of the immune response. In this study we demonstrate that exposure to a psychophysiological stressor (swim stress) increases IL-10 production in female rats in response to an in vivo challenge with bacterial lipopolysaccharide ...

journal_title：Journal of neuroimmunology

authors： Connor TJ,Brewer C,Kelly JP,Harkin A

更新日期：2005-02-01 00:00:00

abstract：:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

journal_title：Journal of neuroimmunology

authors： Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

更新日期：2006-08-01 00:00:00

abstract：:Laquinimod, is a potential oral immunomodulatory drug, for relapsing-remitting multiple sclerosis (RRMS). We analyzed the blood-transcriptional changes in RRMS patients (who participated in the ALLEGRO clinical trial) at one and six months after laquinimod treatment using gene expression microarrays. The molecular eff...

journal_title：Journal of neuroimmunology

authors： Zilkha-Falb R,Gurevich M,Hayardeny L,Achiron A

更新日期：2015-06-15 00:00:00