当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression.

Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression.

Abstract：

:Experimental autoimmune encephalomyelitis (EAE) is a T helper 1 (Th1) cell mediated demyelinating disease and the principal animal model for multiple sclerosis. Spinal cords from SJL mice primed with proteolipid protein peptide 139-151 (pPLP) expressed the chemokines RANTES, MCP-1, MIP-2, KC, MIP-1alpha, MIP-1beta, Mig, and fractalkine. We also identified IP-10 in these samples and described a sequence polymorphism in this transcript. Chemokine expression was specific for tissues of the central nervous system. MCP-1, IP-10, and MIP-2 RNA expression significantly correlated with clinical score. Chemokine receptor expression generally correlated with ligand expression. pPLP-primed mice expressed the Th1-associated markers CCR5 and CXCR3 on mononuclear cells. In addition, cells expressing CCR1, CCR2, CCR3, CCR4, CCR8, and CXCR2 were detected. Here we demonstrate that altered peptide ligand (APL)-induced protection from EAE was accompanied by modulation of chemokine and chemokine receptor expression. Spinal cord tissue sections from APL-protected mice showed greatly reduced levels of all chemokines and of CCR1, CCR5, CCR8, CXCR2 and CXCR3. The Th2-associated chemokine receptors CCR3 and CCR4 were found in protected mice, supporting the hypothesis that Th1 but not Th2 cells are down-regulated by APL treatment. This report concludes that chemokines and chemokine receptors can be useful tools to follow modulation of autoimmune disease.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Fischer FR,Santambrogio L,Luo Y,Berman MA,Hancock WW,Dorf ME

doi

10.1016/s0165-5728(00)00351-9

subject

Has Abstract

pub_date

2000-10-02 00:00:00

pages

195-208

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(00)00351-9

journal_volume

110

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitro.

    abstract：:Insulin-like growth factor-2 (IGF-2) present in media conditioned by non-activated and interferon gamma (IFN gamma)-treated microglia reduces galactocerebroside(+) (GalC) oligodendrocyte apoptosis in cultures derived both from the CG4 cell line and primary rat cortices. Microglia-derived IGF-2 also acts in each cultur...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00011-5

    authors： Nicholas RS,Stevens S,Wing MG,Compston DA

    更新日期：2002-03-01 00:00:00

  • Studies on the intrathecal humoral immune response in canine distemper encephalitis.

    abstract：:Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(86)90073-1

    authors： Vandevelde M,Zurbriggen A,Steck A,Bichsel P

    更新日期：1986-03-01 00:00:00

  • Adrenergic regulation of macrophage-derived tumor necrosis factor-alpha generation during a chronic polyarthritis pain model.

    abstract：:Increases in the levels of proinflammatory cytokines, such as TNF alpha, have been intricately linked with arthritis and the pathogenesis of several models of neuropathic pain. In addition, arthritis (as well as other types of persistent pain) is associated with increased sympathetic activity and alterations of other ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00196-3

    authors： Chou RC,Dong XL,Noble BK,Knight PR,Spengler RN

    更新日期：1998-03-01 00:00:00

  • Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.

    abstract：:Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent a...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.06.014

    authors： Zhang Y,Jalili F,Ouamara N,Zameer A,Cosentino G,Mayne M,Hayardeny L,Antel JP,Bar-Or A,John GR

    更新日期：2010-10-08 00:00:00

  • Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain.

    abstract：:A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynaptic adrenergic sensitivity as well...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00244-7

    authors： Nickola TJ,Ignatowski TA,Spengler RN

    更新日期：2000-07-10 00:00:00

  • Optic nerve involvement in experimental autoimmune encephalomyelitis to homologous spinal cord homogenate immunization in the dark agouti rat.

    abstract：:Dark-Agouti rats were immunized with spinal cord homogenate to develop Experimental Autoimmune Encephalomyelitis, a model of multiple sclerosis. We assessed motor signs and recorded VEPs for five or eight weeks with epidural or epidermal electrodes, respectively, with final histopathology of optic nerves (ONs). Inject...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.09.009

    authors： Castoldi V,Marenna S,Santangelo R,d'Isa R,Cursi M,Chaabane L,Quattrini A,Comi G,Leocani L

    更新日期：2018-12-15 00:00:00

  • Expression of hemokinin 1 mRNA by murine dendritic cells.

    abstract：:Hemokinin 1 is encoded by preprotachykinin C (PPT-C) mRNA, and has been proposed as a regulator of B and T cell lymphopoiesis. Here we demonstrate the expression of mouse PPT-C mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. Expression was detected in freshly isolated CD11...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.06.005

    authors： Nelson DA,Marriott I,Bost KL

    更新日期：2004-10-01 00:00:00

  • Sudden hearing loss as the initial symptom in Japanese patients with multiple sclerosis and seropositive neuromyelitis optica spectrum disorders.

    abstract：:Sudden hearing loss may occur in rare cases of relapsing-remitting multiple sclerosis (RRMS). There have also been reports of idiopathic sudden sensorineural hearing loss (SNHL) in patients with neuromyelitis optica spectrum disorders (NMOSD), but the frequency of such cases is unclear. We conducted a retrospective an...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.06.004

    authors： Tanaka M,Tanaka K

    更新日期：2016-09-15 00:00:00

  • Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-beta.

    abstract：:Bone marrow stromal cells (BMSCs) are strong candidates for cell therapy against human autoimmune diseases. Intravenous administration of syngenic BMSCs to EAMG-model rats effectively ameliorated the disease, partially through a TGF-beta-dependent mechanism. The proliferative ability of T or B cells from EAMG rats was...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.12.005

    authors： Kong QF,Sun B,Bai SS,Zhai DX,Wang GY,Liu YM,Zhang SJ,Li R,Zhao W,Sun YY,Li N,Wang Q,Peng HS,Jin LH,Li HL

    更新日期：2009-02-15 00:00:00

  • Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.

    abstract：:The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. Howe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.09.023

    authors： Jilek S,Kuhle J,Meylan P,Reichhart MD,Pantaleo G,Du Pasquier RA

    更新日期：2007-12-01 00:00:00

  • The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

    abstract：:Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate ph...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.04.019

    authors： Phan TA,Taylor AW

    更新日期：2013-07-15 00:00:00

  • EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype.

    abstract：:In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulato...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.09.007

    authors： Carvalho SC,Apolinário LM,Matheus SM,Santo Neto H,Marques MJ

    更新日期：2013-11-15 00:00:00

  • Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo.

    abstract：:The present study tested whether aging sensitizes hippocampal microglia to a pro-inflammatory challenge ex vivo. Hippocampal microglia from 3 and 24 mo old male F344 x BN F1 rats were exposed to LPS (0, 0.1, 1, 10 and 100 ng/ml) ex vivo. 2 h post-LPS challenge, gene expression of microglial activation markers and cyto...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.05.022

    authors： Frank MG,Barrientos RM,Watkins LR,Maier SF

    更新日期：2010-09-14 00:00:00

  • Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.

    abstract：:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.05.034

    authors： Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

    更新日期：2010-09-14 00:00:00

  • Antibodies to interleukin-1 inhibit cytokine-induced proliferation of neonatal rat Schwann cells in vitro.

    abstract：:Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90018-3

    authors： Lisak RP,Bealmear B

    更新日期：1991-02-01 00:00:00

  • Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients.

    abstract：:Multiple sclerosis (MS) is a devastating autoimmune demyelinating disease of the central nervous system (CNS). This study investigated whether expression and activity of the calcium-activated protease calpain correlated with Th1/Th2 dysregulation in MS patients during states of relapse and remission. Calpain expressio...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.07.016

    authors： Imam SA,Guyton MK,Haque A,Vandenbark A,Tyor WR,Ray SK,Banik NL

    更新日期：2007-10-01 00:00:00

  • Body mass index influence interferon-beta treatment response in multiple sclerosis.

    abstract：:Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI≥25kg/m(2)) had MRI activity compared to 48% of the normal-weight patients (BMI<25kg/m(2)) (p=0.001) du...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jneuroim.2015.09.008

    authors： Kvistad SS,Myhr KM,Holmøy T,Šaltytė Benth J,Wergeland S,Beiske AG,Bjerve KS,Hovdal H,Lilleås F,Midgard R,Pedersen T,Bakke SJ,Michelsen AE,Aukrust P,Ueland T,Sagen JV,Torkildsen Ø

    更新日期：2015-11-15 00:00:00

  • Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice.

    abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory immune response directed against myelin antigens of the central nervous system. In its murine model, EAE, Th17 cells play an important role in disease pathogenesis. These cells can induce blood-brain barrier disruption and CNS immune cells ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.06.002

    authors： Peron JP,Yang K,Chen ML,Brandao WN,Basso AS,Commodaro AG,Weiner HL,Rizzo LV

    更新日期：2010-10-08 00:00:00

  • IL-12, while beneficial, is not essential for the host response to VSV encephalitis.

    abstract：:In this report, the role of STAT4 and local production of interleukin (IL)-12 in the central nervous system (CNS) were examined during experimental vesicular stomatitis virus (VSV) encephalitis. We have previously shown that IL-12 treatment is beneficial both in vitro and in vivo during experimental VSV infection. Thi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00257-6

    authors： Chesler DA,Reiss CS

    更新日期：2002-10-01 00:00:00

  • Effects of beta-IFN-1b treatment in MS patients on adhesion between PBMNCs, HUVECs and MS-HBECs: an in vivo and in vitro study.

    abstract：:The in vivo effects on the expression of adhesion molecules and on the adhesion between mononuclear cells and multiple sclerosis human brain endothelial cells (MS-HBECs) were investigated at the beginning of beta-IFN-1b treatment of MS patients. MS-HBECs were isolated from a surgical specimen obtained from an MS patie...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00114-8

    authors： Corsini E,Gelati M,Dufour A,Massa G,Nespolo A,Ciusani E,Milanese C,La Mantia L,Salmaggi A

    更新日期：1997-10-01 00:00:00

  • Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis.

    abstract：:Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.12.006

    authors： Kato S,Tsuzuki Y,Hokari R,Okada Y,Miyazaki J,Matsuzaki K,Iwai A,Kawaguchi A,Nagao S,Itoh K,Suzuki H,Nabeshima T,Miura S

    更新日期：2005-04-01 00:00:00

  • Transcriptional expression of inflammatory mediators in various somatosensory relay centers in the brain of rat models of peripheral mononeuropathy and local inflammation.

    abstract：:Contradictory results have been reported regarding the role of inflammatory mediators in the central nervous system in mediating neuropathic pain and inflammatory hyperalgesia following peripheral nerve injury or localized inflammation. The present study aims to correlate between the mRNA expression and protein secret...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.05.005

    authors： Chamaa F,Chebaro M,Safieh-Garabedian B,Saadeh R,Jabbur SJ,Saadé NE

    更新日期：2016-08-15 00:00:00

  • Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis.

    abstract：:Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of i...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2018.10.004

    authors： Alrouji M,Manouchehrinia A,Gran B,Constantinescu CS

    更新日期：2019-04-15 00:00:00

  • False-positive acetylcholine receptor antibody results in patients without myasthenia gravis.

    abstract：:Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two pat...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.04.001

    authors： Maddison P,Sadalage G,Ambrose PA,Jacob S,Vincent A

    更新日期：2019-07-15 00:00:00

  • Myasthenia gravis. Identification of skeletal and heart muscle antigens not related to the acetylcholine receptor.

    abstract：:Myasthenia gravis (MG) is a neuromuscular disease thought to have an autoimmune etiology. The acetylcholine receptor has been considered the primary site of antibody binding; however, other muscle components may be involved in the pathogenesis of myasthenia gravis. This study describes a hypertonic sucrose extract of ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(84)90024-9

    authors： Mehl VS,Lang RW

    更新日期：1984-08-01 00:00:00

  • Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.

    abstract：:Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-asso...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.03.002

    authors： Puttini S,Panaite PA,Mermod N,Renaud S,Steck AJ,Kuntzer T

    更新日期：2014-05-15 00:00:00

  • The role of microglia and tumor-primed lymphocytes in the interaction between T lymphocytes and brain endothelial cells.

    abstract：:We investigated the role of IFN-gamma activated microglia in the passage of T lymphocytes across a monolayer of brain endothelial cells (EC) in vitro. Microglia isolated from Fisher 344 (F344) newborn rats were stimulated with IFN-gamma (100 U/ml) for 48 h. T lymphocytes primed with glioma cells were 51Cr-labeled, and...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00163-x

    authors： Watanabe T,Tanaka R,Taniguchi Y,Yamamoto K,Ono K,Yoshida S

    更新日期：1998-01-01 00:00:00

  • Chronic electrical stimulation of the lateral hypothalamus increases natural killer cell cytotoxicity in rats.

    abstract：:Previously, we found that in rats coagulation of the lateral hypothalamus (LH) caused depression of the peripheral blood natural killer cell cytotoxicity (NKCC) and the number of large granular lymphocytes (LGL). In the present work, we have tested the effects on both spleen and blood NKCC of acute (1 day) and chronic...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00214-5

    authors： Wrona D,Trojniar W

    更新日期：2003-08-01 00:00:00

  • An immunoelectron microscopical study of the expression of class II major histocompatibility complex during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice.

    abstract：:Immunoelectron microscopical techniques have been used to study class II major histocompatibility complex (MHC) expression by cells in the spinal cords of Biozzi AB/H mice with chronic relapsing experimental allergic encephalomyelitis. Throughout the course of disease both astrocytes and endothelia failed to express s...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90032-3

    authors： Butter C,O'Neill JK,Baker D,Gschmeissner SE,Turk JL

    更新日期：1991-07-01 00:00:00

  • Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?

    abstract：:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2009.09.013

    authors： Conrady CD,Drevets DA,Carr DJ

    更新日期：2010-03-30 00:00:00