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Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?

Abstract：

:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to quell virus replication, drive the pathogen into a "latent" state, and likely hinder viral reactivation, collateral damage can ensue with demonstrable cell death and foci of tissue pathology in the central nervous system (CNS) as a result of the release of inflammatory mediators including reactive oxygen species. Although rare, HSV-1 is the leading cause of frank sporadic encephalitis that, if left untreated, can result in death. A greater understanding of the contribution of resident glial cells and infiltrating leukocytes within the CNS in response to HSV-1 invasion is necessary to identify candidate molecules as targets for therapeutic intervention to reduce unwarranted inflammation coinciding with the maintenance of the anti-viral state.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Conrady CD,Drevets DA,Carr DJ

doi

10.1016/j.jneuroim.2009.09.013

subject

Has Abstract

pub_date

2010-03-30 00:00:00

pages

1-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(09)00359-2

journal_volume

220

pub_type

杂志文章,评审

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