Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.

abstract：:In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulato...

journal_title：Journal of neuroimmunology

authors： Carvalho SC,Apolinário LM,Matheus SM,Santo Neto H,Marques MJ

更新日期：2013-11-15 00:00:00

abstract：:Following axotomy of the facial nerve microglial cells in the facial nucleus become activated, proliferate, and newly express class I and class II major histocompatibility complex (MHC) antigens. Dexamethasone treatment, starting 2 days prior to axotomy at 1 mg/kg/day, selectively inhibited axotomy-induced MHC class I...

journal_title：Journal of neuroimmunology

authors： Kiefer R,Kreutzberg GW

更新日期：1991-11-01 00:00:00

abstract：:Lewis rats sensitized against peripheral nervous system antigens can be protected against experimental allergic neuritis (EAN) by the intraperitoneal injection of silica quartz dust. Two doses of 200 mg silica given 8 and 11 days post-inoculation (dpi) protected against the development of both clinical and pathologica...

journal_title：Journal of neuroimmunology

authors： Tansey FA,Brosnan CF

更新日期：1982-11-01 00:00:00

abstract：:Sprague-Dawley rats were injected intraperitoneally with a suspension of Trypanosoma brucei brucei. An early induction of major histocompatibility complex (MHC) class I antigens as well as an infiltration of macrophage-like cells and cytotoxic T-cells was detected with immunohistochemical techniques in circumventricul...

journal_title：Journal of neuroimmunology

authors： Schultzberg M,Olsson T,Samuelsson EB,Maehlen J,Kristensson K

更新日期：1989-09-01 00:00:00

abstract：:The in vivo effects on the expression of adhesion molecules and on the adhesion between mononuclear cells and multiple sclerosis human brain endothelial cells (MS-HBECs) were investigated at the beginning of beta-IFN-1b treatment of MS patients. MS-HBECs were isolated from a surgical specimen obtained from an MS patie...

journal_title：Journal of neuroimmunology

authors： Corsini E,Gelati M,Dufour A,Massa G,Nespolo A,Ciusani E,Milanese C,La Mantia L,Salmaggi A

更新日期：1997-10-01 00:00:00

abstract：:Interferon-β (IFN-β) is often discontinued in RRMS patients due to its most common side effect, the flu-like syndrome (FLS). The mechanisms underlying IFN β-induced FLS symptoms are still unclear. The endocannabinoid system (ECS) is a key regulator of pain and inflammation. Thus we tested the hypothesis that the ECS c...

journal_title：Journal of neuroimmunology

authors： Buttari F,Zagaglia S,Marciano L,Albanese M,Landi D,Nicoletti CG,Mercuri NB,Silvestrini M,Provinciali L,Marfia GA,Mori F,Centonze D

更新日期：2017-04-15 00:00:00

abstract：:A systematic study of thymus homogenates and cell suspensions from 13 patients with myasthenia gravis (MG) of recent onset, and 6 non-myasthenic controls, has failed to detect or isolate virus by cell culture with 'rescue techniques', electron microscopy, or intracerebral inoculation into neonatal mice. These results ...

journal_title：Journal of neuroimmunology

authors： Klavinskis LS,Willcox HN,Richmond JE,Newsom-Davis J

更新日期：1986-06-01 00:00:00

abstract：:Chronic asthma is one of the most common respiratory diseases, characterized by airway inflammation. However, little is known whether asthma-induced airway inflammation might influence the brain. We found that chronic asthma not only resulted in peripheral inflammation, but also induced neuroinflammation which was cha...

journal_title：Journal of neuroimmunology

authors： Xia MX,Ding X,Qi J,Gu J,Hu G,Sun XL

更新日期：2014-08-15 00:00:00

abstract：OBJECTIVE:To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS:A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS:AQP1 a...

journal_title：Journal of neuroimmunology

authors： Long Y,Zheng Y,Shan F,Chen M,Fan Y,Zhang B,Gao C,Gao Q,Yang N

更新日期：2014-08-15 00:00:00

abstract：:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or ...

journal_title：Journal of neuroimmunology

authors： Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

更新日期：2010-09-14 00:00:00

abstract：:DNA synthesis was studied in primary glial cell cultures derived from adult human non-neoplastic and neoplastic brain tissues. Enhanced DNA synthesis occurred in 5/5 non-neoplastic astrocyte, one oligodendroglioma, and 2/5 astrocytoma cultures after exposure to medium containing 1.25-12.5% supernatant fluid (SF) from ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Chou SM,Jacobs B,Ransohoff RM,Hahn JF,Bay JW

更新日期：1985-12-01 00:00:00

abstract：:It has been reported that obesity leads to more marked inflammatory responses in a site-specific manner. As has been seen in other animal models of obesity, ovariectomized rodents exhibit obesity and exacerbated fever and anorectic responses to the systemic injection of lipopolysaccharide (LPS). Furthermore, they also...

journal_title：Journal of neuroimmunology

authors： Iwasa T,Matsuzaki T,Tungalagsuvd A,Munkhzaya M,Kawami T,Kato T,Kuwahara A,Yasui T,Irahara M

更新日期：2014-12-15 00:00:00

abstract：:Acute experimental allergic neuritis (EAN) of Lewis rats was monitored by clinical and electrophysiological tests for 60 days. Sciatic nerve myelin proteins were analyzed by quantitative microgel electrophoresis and electroimmunoblotting at different clinical stages of the disease. The clinical severity of EAN and the...

journal_title：Journal of neuroimmunology

authors： Schott K,Jenner A,Wiethölter H,Schabet M,Stevens A

更新日期：1988-11-01 00:00:00

abstract：:To characterize behavioral and physiological alterations induced by viral respiratory infection, C57BL/6 and BALB/c strains of mice were monitored for 2 days before and 4 days after intranasal inoculation with influenza virus. Both strains developed hypothermia, decrease locomotor activity, and decreased delta-wave am...

journal_title：Journal of neuroimmunology

authors： Toth LA,Rehg JE,Webster RG

更新日期：1995-04-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disorder caused by antibody-mediated attack against skeletal muscle nicotinic acetylcholine receptor (AchR) at neuromuscular junction. A close relationship exists between heat shock proteins (HSPs) and numerous autoimmune diseases. HSPs are over expressed to protect the host aga...

journal_title：Journal of neuroimmunology

authors： Patil SA,Katyayani S,Sood A,Kavitha AK,Marimuthu P,Taly AB

更新日期：2013-04-15 00:00:00

abstract：:B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces p...

journal_title：Journal of neuroimmunology

authors： Begum-Haque S,Sharma A,Christy M,Lentini T,Ochoa-Reparaz J,Fayed IF,Mielcarz D,Haque A,Kasper LH

更新日期：2010-02-26 00:00:00

abstract：:Increases in the levels of proinflammatory cytokines, such as TNF alpha, have been intricately linked with arthritis and the pathogenesis of several models of neuropathic pain. In addition, arthritis (as well as other types of persistent pain) is associated with increased sympathetic activity and alterations of other ...

journal_title：Journal of neuroimmunology

authors： Chou RC,Dong XL,Noble BK,Knight PR,Spengler RN

更新日期：1998-03-01 00:00:00

abstract：:We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese. DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 ...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Niino M,Ochi H,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2004-05-01 00:00:00

abstract：:HIV-induced neurological disease is postulated to be caused by indirect mechanisms. Tumor necrosis factor (TNF)alpha is increased in the brains in human immunodeficiency virus (HIV)-associated dementia and in the spinal cord in vacuolar myelopathy and may play a pathogenetic role in these diseases. Microglia, astrocyt...

journal_title：Journal of neuroimmunology

authors： Wesselingh SL,Takahashi K,Glass JD,McArthur JC,Griffin JW,Griffin DE

更新日期：1997-04-01 00:00:00

abstract：:In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long...

journal_title：Journal of neuroimmunology

authors： Van Ranst L,Lauweryns JM

更新日期：1990-09-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB) induces both cellular immunosuppression and an inflammatory response. In an effort to better characterize CPB-induced immune dysfunction, we examined the chemotaxic ability of human granulocytes and macrophages to D-Ala2-Met-enkephalin (DAME) and interleukin (IL)-1 alpha with computer-assi...

journal_title：Journal of neuroimmunology

authors： Stefano GB,Bilfinger TV

更新日期：1993-09-01 00:00:00

abstract：:The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone l...

journal_title：Journal of neuroimmunology

authors： Paciotti GF,Skwerer RG,Tamarkin L

更新日期：1987-10-01 00:00:00

abstract：:Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in...

journal_title：Journal of neuroimmunology

authors： Kato S,Tsuzuki Y,Hokari R,Okada Y,Miyazaki J,Matsuzaki K,Iwai A,Kawaguchi A,Nagao S,Itoh K,Suzuki H,Nabeshima T,Miura S

更新日期：2005-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune demyelinating disease of the central nervous system (CNS). This study investigated whether expression and activity of the calcium-activated protease calpain correlated with Th1/Th2 dysregulation in MS patients during states of relapse and remission. Calpain expressio...

journal_title：Journal of neuroimmunology

authors： Imam SA,Guyton MK,Haque A,Vandenbark A,Tyor WR,Ray SK,Banik NL

更新日期：2007-10-01 00:00:00

abstract：:The timing and intensity of the antibody responses to the marker determinants of synthetic peptide S81 and S82 sequences of bovine myelin basic protein (MBP) (residues 68-83 and 65-83, respectively) were studied in 20 Lewis rats and 6 rabbits. All rats immunized with either peptide in CFA responded with antibody devel...

journal_title：Journal of neuroimmunology

authors： Day ED,Hashim GA,Varitek VA Jr,Paterson PY

更新日期：1981-06-01 00:00:00

abstract：:Astrocytes provide crucial support for neurons and their impairment by viruses or their interactions with anti-viral or autoimmune responses could contribute to neurological disease. We have developed a transgenic mouse model to assess lymphocyte-astrocyte interactions. The major histocompatibility complex (MHC) class...

journal_title：Journal of neuroimmunology

authors： Rall GF,Mucke L,Nerenberg M,Oldstone MB

更新日期：1994-06-01 00:00:00

abstract：:The mechanism behind the association between MHC genes and myasthenia gravis (MG) is not fully understood. In the present study we studied the associations with polymorphisms at HLA-DR3, HLA-B8 and TNF-alpha genes in Swedish patients and healthy individuals. The TNF-alpha-308 allele 2 was associated with female patien...

journal_title：Journal of neuroimmunology

authors： Huang DR,Pirskanen R,Matell G,Lefvert AK

更新日期：1999-02-01 00:00:00

abstract：:Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

journal_title：Journal of neuroimmunology

authors： Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

更新日期：2002-06-01 00:00:00

abstract：:The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression i...

journal_title：Journal of neuroimmunology

authors： André C,O'Connor JC,Kelley KW,Lestage J,Dantzer R,Castanon N

更新日期：2008-08-30 00:00:00

abstract：:CSF and serum levels of soluble Fas were studied in MS patients, in patients with various neurological diseases and in healthy controls. We did not detect differences in serum sFas levels between MS patients and controls. In CSF, despite sFas levels being similar in all patients studied, a statistically significant co...

journal_title：Journal of neuroimmunology

authors： Ciusani E,Frigerio S,Gelati M,Corsini E,Dufour A,Nespolo A,La Mantia L,Milanese C,Massa G,Salmaggi A

更新日期：1998-02-01 00:00:00