Abstract：
:The present study tested whether aging sensitizes hippocampal microglia to a pro-inflammatory challenge ex vivo. Hippocampal microglia from 3 and 24 mo old male F344 x BN F1 rats were exposed to LPS (0, 0.1, 1, 10 and 100 ng/ml) ex vivo. 2 h post-LPS challenge, gene expression of microglial activation markers and cytokines were assessed. 24 mo old animals exhibited a potentiated pro-inflammatory cytokine (IL-1β and IL-6) response to LPS and increased levels of CD11b, Iba-1 and MHCII irrespective of LPS treatment. The present results demonstrate that aging sensitizes hippocampal microglia to pro-inflammatory challenges.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Frank MG,Barrientos RM,Watkins LR,Maier SFdoi
10.1016/j.jneuroim.2010.05.022subject
Has Abstractpub_date
2010-09-14 00:00:00pages
181-4issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(10)00206-7journal_volume
226pub_type
杂志文章abstract：:Enzymatically derived nitric oxide (NO) has been implicated in numerous physiological and pathological processes in the brain. Whereas during development NO participates in developmental and maturation processes, excess NO production in the adult in response to inflammation, injury, or trauma participates in both cell...
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abstract：:Microglia become activated immune cells during infection or disease in the central nervous system (CNS). However, the mechanisms that downregulate activated microglia to prevent immune-mediated damage are not completely understood. Vitamin D3 has been suggested to have immunomodulatory affects, and high levels of vita...
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abstract：:The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...
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pub_type： 杂志文章
doi：10.1016/j.jneuroim.2012.04.019
更新日期：2012-08-15 00:00:00
abstract：:Functional studies of cerebrospinal fluid T lymphocytes during acute viral infections of the nervous system are rare. Recently, we had the opportunity to investigate the requirements for interferon-gamma (IFN-gamma) production of human in vivo activated (primary) cytotoxic T lymphocytes (CTL) generated during acute vi...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(91)90106-h
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abstract：:Opsoclonus is an ocular motility disorder characterized by spontaneous, arrhythmic conjugate saccades of varying amplitude occurring in all directions of gaze without normal intersaccadic interval. Etiological spectrum of opsoclonus encompasses paraneoplastic and neoplastic conditions, infectious and para-infectious e...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2020.577394
更新日期：2020-11-15 00:00:00
abstract：:Based on gene expression data, we tested the P8A-CCL2 variant of the chemokine CCL2, able to interfere with the chemotactic properties of the parental molecule, in relapsing-remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a dose dependent manner. P8A-CCL2 administration, howeve...
journal_title：Journal of neuroimmunology
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pub_type： 杂志文章
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abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...
journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2005.09.002
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2016-12-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2003.12.017
更新日期：2004-04-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/s0165-5728(97)00241-5
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章,评审
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
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abstract：:A high proportion of peptide 1-11 specific T cells from H-2u (V beta 8+, H-2u) mice express the V beta 8 TCR chain. Peptide 89-101 is immunodominant for B10.RIII (V beta 8+, H-2r) mice; thus, it was of interest to determine whether V beta 8 TCR would be over-represented in a population of peptide 89-101-specific T cel...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(93)90012-n
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journal_title：Journal of neuroimmunology
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