Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis.

abstract：:HLA-DR expression on circulating monocytes varies as a function of disease activity in patients with multiple sclerosis (MS), a putative immunopathological demyelinating disorder. Specifically, monocytes isolated from subjects with active MS exhibit reduced HLA-DR antigen density, and immunoregulatory aberrations such...

journal_title：Journal of neuroimmunology

authors： Ransohoff RM,Tuohy VK,Barna BP,Rudick RA

更新日期：1992-04-01 00:00:00

abstract：:Aspects of gene-environment interactions in multiple sclerosis (MS) were analysed in serum samples from 46 MS families (25 sporadic MS cases and 42 familial MS cases): antibodies to the MS-associated human endogenous retrovirus HERV-H, and levels of three components in the innate pathogen-associated molecular pattern ...

journal_title：Journal of neuroimmunology

authors： Christensen T,Petersen T,Thiel S,Brudek T,Ellermann-Eriksen S,Møller-Larsen A

更新日期：2007-02-01 00:00:00

abstract：:The human platelet serotonergic responses of aggregation and uptake were shown to be modulated by muramyl peptides. Muramyl dipeptide inhibited serotonin uptake in a temperature dependent and stereospecific manner. It also blocked the binding to platelets of [3H]imipramine, a well-known inhibitor of serotonin uptake. ...

journal_title：Journal of neuroimmunology

authors： Polanski M,Karnovsky ML

更新日期：1992-03-01 00:00:00

abstract：:Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronc...

journal_title：Journal of neuroimmunology

authors： Caulfield JI,Schopf KJ,Cavigelli SA

更新日期：2020-11-25 00:00:00

abstract：:Peptide p259-271 of the human acetylcholine receptor alpha-subunit, preferentially stimulates T cells of patients with myasthenia gravis (MG) and is an immunodominant epitope for T cells of BALB/c mice. A p259-271 specific T cell line of BALB/c origin was established and was shown to induce experimental MG in naive mi...

journal_title：Journal of neuroimmunology

authors： Katz-Levy Y,Dayan M,Wirguin I,Fridkin M,Sela M,Mozes E

更新日期：1998-05-01 00:00:00

abstract：:This study investigated whether anti-CD40 Ab and 8-oxo-dG attenuate mast cell migration and EAE development. Anti-CD40 Ab and 8-oxo-dG reduced EAE scores, mast cell numbers, expression of adhesion molecules, OX40L and Act1, levels of TNF-α, LTs, expression of cytokines, and co-localization of Treg cells and mast cells...

journal_title：Journal of neuroimmunology

authors： Hong GU,Kim NG,Jeoung D,Ro JY

更新日期：2013-07-15 00:00:00

abstract：:Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerab...

journal_title：Journal of neuroimmunology

authors： Wildner P,Selmaj KW

更新日期：2017-10-15 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease characterized by muscle weakness due to neuromuscular junction (NMJ) damage by anti-acetylcholine receptor (AChR) auto-antibodies and complement. In experimental autoimmune myasthenia gravis (EAMG), which is induced by immunization with Torpedo AChR in CFA, anti-AChR IgG2b an...

journal_title：Journal of neuroimmunology

authors： Huda R,Strait RT,Tüzün E,Finkelman FD,Christadoss P

更新日期：2015-04-15 00:00:00

abstract：:The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion. Nevertheless, Cop 1 Ts cells inhibited the IL-2 response of a pr...

journal_title：Journal of neuroimmunology

authors： Aharoni R,Teitelbaum D,Sela M,Arnon R

更新日期：1998-11-02 00:00:00

abstract：OBJECTIVE:Psychological stress has been implicated in the pathophysiology of both inflammatory and functional gastrointestinal (GI) diseases. The goal of this study was to address neuroendocrine modulation of cytokine production by peripheral blood cells in GI diseases. METHODS:We analyzed the in vitro effects of the ...

journal_title：Journal of neuroimmunology

authors： Lucas A,Cobelens PM,Kavelaars A,Heijnen CJ,Holtmann G,Haag S,Gerken G,Langhorst J,Dobos GJ,Schedlowski M,Elsenbruch S

更新日期：2007-01-01 00:00:00

abstract：:Immunological changes initiated by major operative injury may result in inflammatory responses in both peripheral and central nervous system, which may lead to organ dysfunction. Recent studies indicate that beta-adrenergic receptors (beta-ARs) may mediate production of pro-inflammatory cytokines in the brain. In the ...

journal_title：Journal of neuroimmunology

authors： Wang J,Li J,Sheng X,Zhao H,Cao XD,Wang YQ,Wu GC

更新日期：2010-06-01 00:00:00

abstract：:To determine the role of endogenous interleukin-18 (IL-18) in pneumococcal meningitis, meningitis was induced in IL-18 gene-deficient (IL-18(-/-)) and wild-type (WT) mice by intranasal inoculation of Streptococcus pneumoniae with hyaluronidase. Induction of meningitis resulted in an upregulation of both pro- and matur...

journal_title：Journal of neuroimmunology

authors： Zwijnenburg PJ,van der Poll T,Florquin S,Akira S,Takeda K,Roord JJ,van Furth AM

更新日期：2003-05-01 00:00:00

abstract：:We have established a mouse experimental brain abscess model using Staphylococcus aureus where lesion sites are greatly exaggerated compared to the localized area of initial infection, reminiscent of an overactive immune response. Here we demonstrate the prolonged expression of IL-1 beta, TNF-alpha, and macrophage inf...

journal_title：Journal of neuroimmunology

authors： Baldwin AC,Kielian T

更新日期：2004-06-01 00:00:00

abstract：:The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. Howe...

journal_title：Journal of neuroimmunology

authors： Jilek S,Kuhle J,Meylan P,Reichhart MD,Pantaleo G,Du Pasquier RA

更新日期：2007-12-01 00:00:00

abstract：:The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subje...

journal_title：Journal of neuroimmunology

authors： Cereda C,Baiocchi C,Bongioanni P,Cova E,Guareschi S,Metelli MR,Rossi B,Sbalsi I,Cuccia MC,Ceroni M

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Although the role of inflammation in epilepsy pathogenesis has been extensively investigated, the inflammasome complex, a key component of neuroinflammation, has been understudied in epilepsy patients. METHODS:To better understand the involvement of this system in epilepsy, levels of inflammasome complex co...

journal_title：Journal of neuroimmunology

authors： Ulusoy C,Vanlı-Yavuz EN,Şanlı E,Timirci-Kahraman Ö,Yılmaz V,Bebek N,Küçükali Cİ,Baykan B,Tüzün E

更新日期：2020-10-15 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones (TZDs) and 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study ai...

journal_title：Journal of neuroimmunology

authors： Storer PD,Xu J,Chavis J,Drew PD

更新日期：2005-04-01 00:00:00

abstract：:The hormone 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) has immune modulatory activities in vitro and in vivo, and can prevent or delay the onset of experimental or spontaneous autoimmune diseases. At therapeutical doses, however, hypercalcemic side effects are found. The present experiments examined the effects of ...

journal_title：Journal of neuroimmunology

authors： Branisteanu DD,Waer M,Sobis H,Marcelis S,Vandeputte M,Bouillon R

更新日期：1995-09-01 00:00:00

abstract：:Changes in mitogen-induced splenocyte proliferation and NK activity were evaluated after acute (1 h) and chronic (6 d) in vivo treatment of rats with the synthetic cannabinoid compound CP-55,940. At a dose of 0.4 mg/kg i.p. it significantly inhibited the splenocyte proliferative response to PHA and NK activity but hal...

journal_title：Journal of neuroimmunology

authors： Patrini G,Sacerdote P,Fuzio D,Manfredi B,Parolaro D

更新日期：1997-12-01 00:00:00

abstract：:The presence and severity of tardive dyskinesia were determined in 66 patients with chronic psychiatric disorders treated with chlorpromazine. The patients were classified according to the presence of antinuclear antibodies, the lupus anticoagulant, and the HLA antigen Bw44. The severity of orofacial dyskinesia was es...

journal_title：Journal of neuroimmunology

authors： Canoso RT,Romero JA,Yunis EJ

更新日期：1986-09-01 00:00:00

abstract：:We found that rejuvenation of the recipient immunity by inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss and degeneration of the spiral ganglion in SAMP1 mice, a murine model of ...

journal_title：Journal of neuroimmunology

authors： Iwai H,Inaba M

更新日期：2012-09-15 00:00:00

abstract：:Microglia become activated immune cells during infection or disease in the central nervous system (CNS). However, the mechanisms that downregulate activated microglia to prevent immune-mediated damage are not completely understood. Vitamin D3 has been suggested to have immunomodulatory affects, and high levels of vita...

journal_title：Journal of neuroimmunology

authors： Boontanrart M,Hall SD,Spanier JA,Hayes CE,Olson JK

更新日期：2016-03-15 00:00:00

abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is a well-characterized murine model of the chronic-progressive form of human multiple sclerosis (MS) characterized by the activation of myelin-specific autoreactive CD4 Th1 cells via epitope spreading. To gain an understanding of the po...

journal_title：Journal of neuroimmunology

authors： Mack CL,Vanderlugt-Castaneda CL,Neville KL,Miller SD

更新日期：2003-11-01 00:00:00

abstract：:Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17+/-6 ng/ml at baseline to 28+/-8 ng/ml at 6 ...

journal_title：Journal of neuroimmunology

authors： Mahon BD,Gordon SA,Cruz J,Cosman F,Cantorna MT

更新日期：2003-01-01 00:00:00

abstract：:We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphobl...

journal_title：Journal of neuroimmunology

authors： Lindsey JW,Hatfield LM

更新日期：2010-12-15 00:00:00

abstract：:Although multiple sclerosis is predominantly regarded as a disease of young adulthood, up to 5% of MS patients are diagnosed prior to age eighteen. The predominant form of MS is relapsing-remitting characterized by exacerbations of symptoms followed by periods of remission. The majority of disease modifying drugs targ...

journal_title：Journal of neuroimmunology

authors： Cala CM,Moseley CE,Steele C,Dowdy SM,Cutter GR,Ness JM,DeSilva TM

更新日期：2016-08-15 00:00:00

abstract：:The role of autoantibody responses in pathogenesis or progression of multiple sclerosis (MS) remains controversial. This is partly because the methods that can distinctly identify pathogenic antibody reactivities targeting native membrane proteins from the reactivities that originate as an epiphenomenon in such diseas...

journal_title：Journal of neuroimmunology

authors： Aslam M,Kalluri SR,Cepok S,Kraus V,Buck D,Srivastava R,Hemmer B

更新日期：2010-04-15 00:00:00

abstract：:We studied the effect of acute (1 h) or chronic exposure (7 and 14 days) to delta9-tetrahydrocannabinol (delta9-THC) on immune parameters in male Swiss mice. One hour after a dose of 10 mg/kg s.c., the splenocyte proliferative response to ConA and NK activity were not inhibited, but there was a significant decrease in...

journal_title：Journal of neuroimmunology

authors： Massi P,Sacerdote P,Ponti W,Fuzio D,Manfredi B,Viganó D,Rubino T,Bardotti M,Parolaro D

更新日期：1998-12-01 00:00:00

abstract：:Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren'...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Takahashi T,Fujihara K,Misu T,Abe M,Ishii T,Aoki M,Nakashima I

更新日期：2020-06-15 00:00:00

abstract：:IFN-gamma (IFN-gamma) has been shown to activate astrocytes to acquire immune functions. In this study the effect of IFN-gamma on murine astrocytes was investigated via microarray analysis. The activating effect of IFN-gamma on the astrocyte transcriptome showed predominance toward pathways involved in adaptive immuni...

journal_title：Journal of neuroimmunology

authors： Halonen SK,Woods T,McInnerney K,Weiss LM

更新日期：2006-06-01 00:00:00