TNF and sTNFR1/2 plasma levels in ALS patients.

abstract：:The subunit composition of acetylcholine receptor-like protein(s) (AChR-LP) expressed by normal thymus was investigated. In skeletal muscle, the AChR exists in two forms, an embryonic form which contains the gamma-subunit and an adult form where the gamma-subunit is substituted by a different, homologous subunit calle...

journal_title：Journal of neuroimmunology

authors： Nelson S,Conti-Tronconi BM

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS:T...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Liu G,Duan Y,Han X,Dong H,Geng J

更新日期：2016-12-15 00:00:00

abstract：:We have recently demonstrated that ConA-induced suppressor cell function is defective in chronic inflammatory demyelinating polyneuropathy (CIDP). To assess whether this defect plays a role in disease activity and its reversal is important in recovery, we studied modifications of ConA-induced suppressor cell function ...

journal_title：Journal of neuroimmunology

authors： De Luca G,Lugaresi A,Iarlori C,Marzoli F,Di Iorio A,Gambi D,Uncini A

更新日期：1999-03-01 00:00:00

abstract：:Zymosan has previously been reported to have both pro-inflammatory and anti-inflammatory effects. Here we demonstrate that low dose zymosan prevented or reversed chronic and relapsing paralysis in EAE. In suppressing CNS autoimmune inflammation, zymosan not only regulated APC costimulator and MHC class II expression, ...

journal_title：Journal of neuroimmunology

authors： Li H,Gonnella P,Safavi F,Vessal G,Nourbakhsh B,Zhou F,Zhang GX,Rostami A

更新日期：2013-01-15 00:00:00

abstract：:We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8+ (putative suppressor...

journal_title：Journal of neuroimmunology

authors： Lisak RP,Zweiman B,Guerrero F,Moskovitz AR

更新日期：1985-05-01 00:00:00

abstract：:In this report, the role of STAT4 and local production of interleukin (IL)-12 in the central nervous system (CNS) were examined during experimental vesicular stomatitis virus (VSV) encephalitis. We have previously shown that IL-12 treatment is beneficial both in vitro and in vivo during experimental VSV infection. Thi...

journal_title：Journal of neuroimmunology

authors： Chesler DA,Reiss CS

更新日期：2002-10-01 00:00:00

abstract：:Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared ...

journal_title：Journal of neuroimmunology

authors： Mutnal MB,Cheeran MC,Hu S,Little MR,Lokensgard JR

更新日期：2010-10-08 00:00:00

abstract：:Human sera from patients with multiple sclerosis (MS) were tested using an enzyme-linked immunosorbent assay (ELISA) method on well plates coated with various dicarboxylic acid (C4 to C10) protein conjugates. Specific immunological binding was found with an azelaic acid (AzeA, C9) conjugate. The antibody titer was hig...

journal_title：Journal of neuroimmunology

authors： Daverat P,Geffard M,Orgogozo JM

更新日期：1989-04-01 00:00:00

abstract：:Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

journal_title：Journal of neuroimmunology

authors： Calabresi PA,Yun SH,Allie R,Whartenby KA

更新日期：2002-06-01 00:00:00

abstract：:Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 as...

journal_title：Journal of neuroimmunology

authors： Yuhas Y,Ashkenazi S,Berent E,Weizman A

更新日期：2017-04-15 00:00:00

abstract：:Melatonin is known as an antistress and immunostimulator compound while glucocorticoids have immunosuppressive function. The mechanism of action of both the hormones on immune cells is still a question. We found that melatonin improved the effect of dexamethasone (synthetic glucocorticoid) induced immunosuppression of...

journal_title：Journal of neuroimmunology

authors： Vishwas DK,Mukherjee A,Haldar C

更新日期：2013-06-15 00:00:00

abstract：:Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish popula...

journal_title：Journal of neuroimmunology

authors： Mirowska-Guzel D,Gromadzka G,Mach A,Czlonkowski A,Czlonkowska A

更新日期：2011-07-01 00:00:00

abstract：:Cloned cerebrovascular endothelial cells (CVE) persistently infected with Theiler's virus (PI-CVE) have been established and characterized. The CVE were derived from strains of mice that are susceptible (SJL/J and CBA) and resistant (BALB/c) to Theiler's virus-induced demyelination (TVID). The cells were persistently ...

journal_title：Journal of neuroimmunology

authors： Sapatino BV,Petrescu AD,Rosenbaum BA,Smith R 3rd,Piedrahita JA,Welsh CJ

更新日期：1995-11-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune c...

journal_title：Journal of neuroimmunology

authors： Weber A,Wandinger KP,Mueller W,Aktas O,Wengert O,Grundström E,Ehrlich S,Windemuth C,Kuhlmann T,Wienker T,Brück W,Zipp F

更新日期：2004-04-01 00:00:00

abstract：:Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown. The level of plasma Chit activity positively correlates with Alzheimer's disea...

journal_title：Journal of neuroimmunology

authors： Sotgiu S,Musumeci S,Marconi S,Gini B,Bonetti B

更新日期：2008-06-15 00:00:00

abstract：:Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, I...

journal_title：Journal of neuroimmunology

authors： Khalil M,Reindl M,Lutterotti A,Kuenz B,Ehling R,Gneiss C,Lackner P,Deisenhammer F,Berger T

更新日期：2006-05-01 00:00:00

abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

journal_title：Journal of neuroimmunology

authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

更新日期：1989-05-01 00:00:00

abstract：:An increased proportion of citrullinated MBP (MBP-C8) occurs in the brains of multiple sclerosis (MS) patients. In this study, MBP-C8 from guinea pig (GP) brains was isolated and found encephalitogenic in Lewis rats upon immunization. An encephalitogenic T cell line selected with MBP-C8 preferentially reacted with MBP...

journal_title：Journal of neuroimmunology

authors： Cao L,Sun D,Whitaker JN

更新日期：1998-08-01 00:00:00

abstract：:Based on gene expression data, we tested the P8A-CCL2 variant of the chemokine CCL2, able to interfere with the chemotactic properties of the parental molecule, in relapsing-remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a dose dependent manner. P8A-CCL2 administration, howeve...

journal_title：Journal of neuroimmunology

authors： Brini E,Ruffini F,Bergami A,Brambilla E,Dati G,Greco B,Cirillo R,Proudfoot AE,Comi G,Furlan R,Zaratin P,Martino G

更新日期：2009-04-30 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barré syndrome (GBS). Intravenous immunoglobulins (IVIg) are an effective treatment for GBS, but their mechanism of action is not well understood. Here we tested whether IVIg treatment, a potent modulator of proinflammatory assaults, reduces inflam...

journal_title：Journal of neuroimmunology

authors： Enders U,Toyka KV,Hartung HP,Gold R

更新日期：1997-06-01 00:00:00

abstract：:Opioid peptides have been reported by many laboratories to modulate in vitro and in vivo cell-mediated and humoral immune responses. However, less attention has been afforded to the class or classes of opioid receptors involved in these immunomodulatory effects. Previous studies by this laboratory indicated that beta-...

journal_title：Journal of neuroimmunology

authors： Morgan EL

更新日期：1996-03-01 00:00:00

abstract：:To study the role of cell adhesion molecules in the fatal CD8+ T-cell mediated meningitis which is induced by intracerebral infection with lymphocytic choriomeningitis virus, the expression of relevant molecules on inflammatory cells and local endothelium was analyzed immunohistochemically. Most inflammatory cells wer...

journal_title：Journal of neuroimmunology

authors： Marker O,Scheynius A,Christensen JP,Thomsen AR

更新日期：1995-10-01 00:00:00

abstract：:Naive Th cells obtained from OVA(323-339)-specific DO11.10 TCR-Tg mice did not express preproenkephalin (PPE) mRNA. However, culture of naive Th cells with OVA(323-339) peptide (OVA-pep) plus IL-2 under Th2-inducing conditions for 7 days resulted in an induction of PPE mRNA. The PPE mRNA was also induced by culturing ...

journal_title：Journal of neuroimmunology

authors： Yahata T,Yahata C,Ohta A,Sekimoto M,Kitamura H,Iwakabe K,Habu S,Azuma S,Nakui M,Sato M,Koda T,Nishimura T

更新日期：2000-06-26 00:00:00

abstract：:Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), characterized by progressive weakness associated with robust ITA...

journal_title：Journal of neuroimmunology

authors： Pachner AR,Brady J,Narayan K

更新日期：2007-10-01 00:00:00

abstract：:Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the...

journal_title：Journal of neuroimmunology

authors： Laman JD,van Meurs M,Schellekens MM,de Boer M,Melchers B,Massacesi L,Lassmann H,Claassen E,Hart BA

更新日期：1998-06-01 00:00:00

abstract：:This study examined the mechanism by which exposure to lipopolysaccharide (LPS) alters mu-opioid receptor (MOR) expression in immune and neuronal cells using an in vitro conditioned medium model system. We found that LPS stimulated the intracellular accumulation of reactive oxygen species (ROS) and MOR expression in m...

journal_title：Journal of neuroimmunology

authors： Langsdorf EF,Mao X,Chang SL

更新日期：2011-07-01 00:00:00

abstract：:Transplantation of a pituitary graft under the kidney capsule and the resulting elevation of serum prolactin enhances the primary humoral antibody response to sheep red blood cells. Enhancement of the response is not due to marked changes in the percentage of T-cells and their subsets, B-cells, or the number of nuclea...

journal_title：Journal of neuroimmunology

authors： Cross RJ,Campbell JL,Roszman TL

更新日期：1989-11-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as...

journal_title：Journal of neuroimmunology

authors： Marie-Claire C,Courtin C,Curis E,Bouaziz-Amar E,Laplanche JL,Jacob A,Etain B,Blanchard A,Bellivier F

更新日期：2019-09-15 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the opportunistic infections. It is observed in patients with HIV infection, lymphoid malignancies, after organ- and stem cell transplantations an...

journal_title：Journal of neuroimmunology

authors： Weissert R

更新日期：2011-02-01 00:00:00

abstract：:The cytokine interleukin-1 (IL-1) is involved in a wide range of inflammatory and immune responses. As such, IL-1 could play a role in peripheral nerve repair mechanisms. Specifically, by its already established properties as a regulator of nerve growth factor (NGF) synthesis, and as a chemotactant to macrophages. We ...

journal_title：Journal of neuroimmunology

authors： Rotshenker S,Aamar S,Barak V

更新日期：1992-07-01 00:00:00