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Interleukin-4-dependent induction of preproenkephalin in antigen-specific T helper-type 2 (Th2) cells.

Abstract：

:Naive Th cells obtained from OVA(323-339)-specific DO11.10 TCR-Tg mice did not express preproenkephalin (PPE) mRNA. However, culture of naive Th cells with OVA(323-339) peptide (OVA-pep) plus IL-2 under Th2-inducing conditions for 7 days resulted in an induction of PPE mRNA. The PPE mRNA was also induced by culturing with OVA-pep plus IL-2 (neutral condition). However, PPE mRNA induction under neutral conditions was totally abrogated by addition of anti-IL-4 mAb. The existence of methionine-enkephalin was also demonstrated in peptidase-digested peptides derived from Th2 cell lysate. These results demonstrate that IL-4 is a critical factor for the induction of PPE mRNA in freshly expanded antigen-specific Th2 cells.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Yahata T,Yahata C,Ohta A,Sekimoto M,Kitamura H,Iwakabe K,Habu S,Azuma S,Nakui M,Sato M,Koda T,Nishimura T

doi

10.1016/s0165-5728(00)00188-0

subject

Has Abstract

pub_date

2000-06-26 00:00:00

pages

103-8

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572800001880

journal_volume

105

pub_type

杂志文章

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