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Band 1 and voltage-sensitive Na+ channels are not codistributed in cultured rodent neuronal cells.

Abstract：

:The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high molecular weight component. Morphologically differentiated clone NB2a neuroblastoma cells have 2-3 times the amount of band 1 and 1.5 times the relative rate of synthesis of band 1 as undifferentiated cells. The anti-band 1 serum reacts with both adult mouse and rat brain but not 3 cultured rat neuronal lines known to have active Na+ channels. Thus either band 1 is not a component of the Na+ channel or individual cultured murine neuronal lines has distinct macromolecular Na+ channels.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Akeson R,Graham K

doi

10.1016/0165-5728(81)90028-x

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

239-48

issue

3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(81)90028-X

journal_volume

1

pub_type

杂志文章

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