Thymic myoid cells express high levels of muscle genes.

abstract：:Polymyositis (PM) is an inflammatory muscle disease caused by autoimmune dysfunction, considered to be caused by cytotoxic CD8 T cells. To date, no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DC) presenting p...

journal_title：Journal of neuroimmunology

authors： Kawachi I,Tanaka K,Tanaka M,Tsuji S

更新日期：2001-07-02 00:00:00

abstract：:Intrathecal Immunoglobulin G (IgG) is elevated in some central nervous system (CNS) diseases and microglia upregulate Fcγ receptors in various neurological disorders. However, the interaction between IgG or IgG immune complexes and microglial Fcγ receptors is not fully understood. In this study, the effect of IgG(1) i...

journal_title：Journal of neuroimmunology

authors： Parajuli B,Sonobe Y,Kawanokuchi J,Doi Y,Noda M,Takeuchi H,Mizuno T,Suzumura A

更新日期：2012-03-01 00:00:00

abstract：:We have previously demonstrated that central administration of interleukin (IL)-1beta suppresses natural killer (NK) cell activity, impairs NK-mediated lung clearance of tumor cells, and enhances tumor colonization. The central pathways activated by IL-1beta are as yet unknown. Using an in vivo model of tumor coloniza...

journal_title：Journal of neuroimmunology

authors： Hodgson DM,Yirmiya R,Taylor AN

更新日期：2001-09-03 00:00:00

abstract：OBJECTIVE:To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS:A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS:AQP1 a...

journal_title：Journal of neuroimmunology

authors： Long Y,Zheng Y,Shan F,Chen M,Fan Y,Zhang B,Gao C,Gao Q,Yang N

更新日期：2014-08-15 00:00:00

abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

journal_title：Journal of neuroimmunology

authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

更新日期：1989-05-01 00:00:00

abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

journal_title：Journal of neuroimmunology

authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

更新日期：2016-01-15 00:00:00

abstract：:Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

journal_title：Journal of neuroimmunology

authors： Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

更新日期：2002-01-01 00:00:00

abstract：:Sprague-Dawley rats were injected intraperitoneally with a suspension of Trypanosoma brucei brucei. An early induction of major histocompatibility complex (MHC) class I antigens as well as an infiltration of macrophage-like cells and cytotoxic T-cells was detected with immunohistochemical techniques in circumventricul...

journal_title：Journal of neuroimmunology

authors： Schultzberg M,Olsson T,Samuelsson EB,Maehlen J,Kristensson K

更新日期：1989-09-01 00:00:00

abstract：:The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated wit...

journal_title：Journal of neuroimmunology

authors： Dourado ME Junior,Ferreira LC,Freire-Neto FP,Jeronimo SM

更新日期：2016-09-15 00:00:00

abstract：:A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

journal_title：Journal of neuroimmunology

authors： Walker AG,Chapman J,Bruce CB,Rumsby MG

更新日期：1984-11-01 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and cho...

journal_title：Journal of neuroimmunology

authors： Tonelli LH,Maeda S,Rapp KL,Sternberg EM

更新日期：2003-07-01 00:00:00

abstract：:Migraine is believed to be a chronic neurological disorder with the exact aetiology being unknown. But, there is a debate on the role of immune dysfunction in migraine pathophysiology. Hence, authors made a debut attempt to explore the link between lymphocyte subset populations and migraine. A significant increase in ...

journal_title：Journal of neuroimmunology

authors： Arumugam M,Parthasarathy V

更新日期：2016-01-15 00:00:00

abstract：:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

journal_title：Journal of neuroimmunology

authors： Frohman EM,Vayuvegula B,van den Noort S,Gupta S

更新日期：1988-01-01 00:00:00

abstract：:It is widely believed that multiple sclerosis is a T-cell mediated autoimmune disease associated with abnormalities in immunoregulation. This large, prospective study evaluated the lymphocyte immunophenotypic profile of 246 MS patients, divided clinically into a remitting/relapsing group (n = 176) and a progressive gr...

journal_title：Journal of neuroimmunology

authors： Strauss K,Hulstaert F,Deneys V,Mazzon AM,Hannet I,De Bruyère M,Reichert T,Sindic CJ

更新日期：1995-12-31 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma agonist pioglitazone is FDA-approved for treatment of type-2 diabetes due to insulin sensitizing effects. However pioglitazone has anti-inflammatory and neuroprotective effects, reduces glial and T-cell activation, and reduces signs in an animal model of multiple sc...

journal_title：Journal of neuroimmunology

authors： Kaiser CC,Shukla DK,Stebbins GT,Skias DD,Jeffery DR,Stefoski D,Katsamakis G,Feinstein DL

更新日期：2009-06-25 00:00:00

abstract：:A recent meta-analysis of genome-wide association screens coupled to a replication exercise in a combined US/UK collection led to the identification of 4 single nucleotide polymorphisms (SNPs) in three gene loci, i.e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of signif...

journal_title：Journal of neuroimmunology

authors： Swaminathan B,Matesanz F,Cavanillas ML,Alloza I,Otaegui D,Olascoaga J,Cénit MC,de las Heras V,Barcina MG,Arroyo R,Alcina A,Fernandez O,Antigüedad A,Urcelay E,Vandenbroeck K

更新日期：2010-06-01 00:00:00

abstract：:To elucidate the factor(s) accelerating the autoimmune disease processes, we induced two types of experimental autoimmune encephalomyelitis (EAE), severe and very mild, in F344 rats by immunization with myelin basic protein (MBP) plus pertussis toxin (PT) (PT+) or with MBP alone (PT-) and compared the differences betw...

journal_title：Journal of neuroimmunology

authors： Arimoto H,Tanuma N,Jee Y,Miyazawa T,Shima K,Matsumoto Y

更新日期：2000-04-03 00:00:00

abstract：:Th17 cells play an important role in multiple sclerosis (MS) and its autoimmune model, experimental autoimmune encephalomyelitis (EAE). However, studies have not addressed how enhanced Th17 immune responses can affect demyelinating diseases. We induced EAE with MOG in RORγt transgenic C57BL/6 mice that overexpress a T...

journal_title：Journal of neuroimmunology

authors： Martinez NE,Sato F,Omura S,Kawai E,Takahashi S,Yoh K,Tsunoda I

更新日期：2014-11-15 00:00:00

abstract：:Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n=44) or Tourette syndrome (n=40) as compared to ...

journal_title：Journal of neuroimmunology

authors： Morris-Berry CM,Pollard M,Gao S,Thompson C,Tourette Syndrome Study Group.,Singer HS

更新日期：2013-11-15 00:00:00

abstract：:Cerebral ischaemia is a common occurrence in a range of pathological conditions, including stroke and traumatic brain injury. Two of the components in ischaemia are tissue hypoxia and the release of pro-inflammatory agents such as TNF-alpha. The role of TNF-alpha in an ischaemic/hypoxic episode is still controversial,...

journal_title：Journal of neuroimmunology

authors： Batti L,O'Connor JJ

更新日期：2010-01-25 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter, is neurotoxic at high concentrations. Neuroglial cells, including astrocytes and microglia, play an important role in regulating its extracellular levels. Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammato...

journal_title：Journal of neuroimmunology

authors： Klegeris A,Walker DG,McGeer PL

更新日期：1997-09-01 00:00:00

abstract：:Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

journal_title：Journal of neuroimmunology

authors： Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

更新日期：1989-12-01 00:00:00

abstract：:The role of autoantibody responses in pathogenesis or progression of multiple sclerosis (MS) remains controversial. This is partly because the methods that can distinctly identify pathogenic antibody reactivities targeting native membrane proteins from the reactivities that originate as an epiphenomenon in such diseas...

journal_title：Journal of neuroimmunology

authors： Aslam M,Kalluri SR,Cepok S,Kraus V,Buck D,Srivastava R,Hemmer B

更新日期：2010-04-15 00:00:00

abstract：:Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

journal_title：Journal of neuroimmunology

authors： Vandevelde M,Zurbriggen A,Steck A,Bichsel P

更新日期：1986-03-01 00:00:00

abstract：:Guinea pigs inoculated with bovine spinal cord ventral horn homogenate develop a syndrome termed experimental autoimmune gray matter disease (EAGMD) characterized by extremity weakness, bulbar signs, and a loss of lower and upper motoneurons. To provide evidence for the role of autoimmune mechanisms, we have administe...

journal_title：Journal of neuroimmunology

authors： Tajti J,Stefani E,Appel SH

更新日期：1991-11-01 00:00:00

abstract：:The present work examined the effects induced by dibutyryl cyclic adenosine monophosphate (dB-cAMP) on microglial cells in primary glial cell cultures from newborn rats. Microglial cells were identified by OX42 immunohistochemistry and nucleoside diphosphatase histochemistry. Double staining for astrocytes was carried...

journal_title：Journal of neuroimmunology

authors： Dalmau I,Castellano B,Pedersen EB,Finsen B,Zimmer J,González B

更新日期：1996-11-01 00:00:00

abstract：:Neuronal apoptosis has recently been implicated in multiple sclerosis (MS). Apoptotic cell death of neurons is induced in cultures exposed to cerebrospinal fluid (CSF) from MS patients. Since caspases are essential in the regulation of apoptosis, direct evidence was sought linking caspases to CSF-induced neuronal deat...

journal_title：Journal of neuroimmunology

authors： Cid C,Alvarez-Cermeño JC,Regidor I,Plaza J,Salinas M,Alcázar A

更新日期：2003-03-01 00:00:00

abstract：:A two-color immunofluorescence analysis of circulating abnormal T lymphocytes bearing both helper (T4) and suppressor/cytotoxic (Leu2a) T cell markers (double marker cells) was performed by means of the laser flow cytometry system. The double marker cell level was very low in 6 patients with multiple sclerosis and 12 ...

journal_title：Journal of neuroimmunology

authors： Matsui M,Kameyama M

更新日期：1986-06-01 00:00:00

abstract：:Recent studies suggest that monocyte activation may play a role in ALS pathogenesis. Therefore, monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), and plasma levels of MCP-1 were measured in 42 sALS patients, 38 healthy and 34 age-related macular degeneration (ARMD) controls. MCP-1 was elevate...

journal_title：Journal of neuroimmunology

authors： Zhang R,Gascon R,Miller RG,Gelinas DF,Mass J,Lancero M,Narvaez A,McGrath MS

更新日期：2006-10-01 00:00:00