当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Reduction of the microglial cell number in rat primary glial cell cultures by exogenous addition of dibutyryl cyclic adenosine monophosphate.

Reduction of the microglial cell number in rat primary glial cell cultures by exogenous addition of dibutyryl cyclic adenosine monophosphate.

Abstract：

:The present work examined the effects induced by dibutyryl cyclic adenosine monophosphate (dB-cAMP) on microglial cells in primary glial cell cultures from newborn rats. Microglial cells were identified by OX42 immunohistochemistry and nucleoside diphosphatase histochemistry. Double staining for astrocytes was carried out by combination with glial fibrillary acidic protein immunolabeling. Addition of 0.25 mM dB-cAMP to the cultures decreased the microglial cell number about sixfold. The findings suggest that the effect of dB-cAMP on the microglial cells might be either a direct action of dB-cAMP on the microglial cells or an indirect effect mediated by the astroglial cells.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Dalmau I,Castellano B,Pedersen EB,Finsen B,Zimmer J,González B

doi

10.1016/s0165-5728(96)00074-4

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

123-9

issue

2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(96)00074-4

journal_volume

70

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Alterations in cell-mediated immune response in subacute sclerosing panencephalitis.

    abstract：:To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we analyzed proliferation and cytokine secretion of cells from 35 patients and 42 healthy controls (HC) in response to central nervous system (CNS) antigens. The proliferation in response to myelin basic protein (MBP), myelin oligodendrocyt...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.09.002

    authors： Yentür SP,Gürses C,Demirbilek V,Yilmaz G,Onal AE,Yapici Z,Yalçinkaya C,Cokar O,Gökyiğit A,Saruhan-Direskeneli G

    更新日期：2005-12-30 00:00:00

  • Paradoxes of immunosuppression in mouse models of withdrawal.

    abstract：:Previously, our laboratory showed that either abrupt (AW) or precipitated withdrawal (PW) from morphine led to profound suppression of murine splenic antibody responses to sheep red blood cells at 24 h post-withdrawal. In the present studies, we examined the immune mechanisms mediating suppression at that time point. ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2003.10.024

    authors： Rahim RT,Feng P,Meissler JJ,Rogers TJ,Zhang L,Adler MW,Eisenstein TK

    更新日期：2004-02-01 00:00:00

  • Restriction fragment length polymorphism analysis of HLA-DR- and DQ-linked alleles in multiple sclerosis in Spain.

    abstract：:HLA-DR allele subtypes in multiple sclerosis (MS) individuals in Spain were determined by restriction fragment length polymorphism (RFLP) analysis. The well-established association of DRw15, DQw6, Dw2 alleles and MS susceptibility was confirmed. The strength of its association, however, was relatively weak in our MS p...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90076-w

    authors： Clerici N,Fernández M

    更新日期：1992-12-01 00:00:00

  • T-cell-mediated epineurial vasculitis and humoral-mediated microangiopathy in cryoglobulinemic neuropathy.

    abstract：:We used immunohistochemistry to assess the role of humoral and cellular factors in endoneurial microangiopathy and epineurial vasculitis in 15 nerve biopsies of patients with axonal neuropathy and monoclonal or mixed cryoglobulinemia (CG). Deposition of immunoglobulins and cytolytic complement was detected in endoneur...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00191-9

    authors： Bonetti B,Invernizzi F,Rizzuto N,Bonazzi ML,Zanusso GL,Chinaglia G,Monaco S

    更新日期：1997-03-01 00:00:00

  • Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India.

    abstract：:Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.06.002

    authors： Kumar MM,Venkataswamy MM,Sathyanarayanan G,Thippeswamy H,Chandra PS,Mani RS

    更新日期：2017-09-15 00:00:00

  • Stiff person spectrum disorders: An illustrative case series of their phenotypic and antibody diversity.

    abstract：:Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiph...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2020.577192

    authors： Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

    更新日期：2020-04-15 00:00:00

  • Autoantibodies against pituitary peptides in sera from patients with multiple sclerosis.

    abstract：:Autoantibodies against pituitary peptides were demonstrated in sera from multiple sclerosis (MS) patients. Ten patients with lupus erythematosus disseminatus (SLE) and 97 healthy blood donors served as controls. The sera were used as primary antibodies in the indirect immuno-enzyme cytochemical (IEC) method, with fixe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90007-3

    authors： Hansen BL,Hansen GN,Hagen C,Brodersen P

    更新日期：1983-10-01 00:00:00

  • Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells.

    abstract：:Human G-protein-coupled formyl peptide receptor-like 1 and its mouse homologue formyl peptide receptor 2 mediate the chemotactic activity of a variety of pathogen and host-derived peptides, including amyloid beta(42), a key causative factor in Alzheimer's disease (AD).Here, we found that polyinosine-polycytidylic acid...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.05.018

    authors： Chen K,Huang J,Liu Y,Gong W,Cui Y,Wang JM

    更新日期：2009-08-18 00:00:00

  • Interleukin-3 and encephalitogenic activity of SJL/J myelin basic protein-specific T cell lines.

    abstract：:Myelin basic protein (MBP)-specific SJL/J T cells were cultured in normal growth medium or growth medium supplemented with 10% culture supernatant from WEHI-3 cells, a source of interleukin-3 (IL-3), or with recombinant IL-3. T cell lines cultured with IL-3 supplementation were more encephalitogenic compared to parall...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90076-b

    authors： Zhao ML,Xia JQ,Fritz RB

    更新日期：1993-03-01 00:00:00

  • T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model.

    abstract：:The experimental autoimmune encephalomyelitis (EAE) model is indispensable for autoimmunity research, but model-specific T cell dynamics are sparsely studied. We used next-generation immunosequencing across lymphoid organs, blood and spinal cord in response to immunization with myelin basic protein (MBP) to study T ce...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.03.014

    authors： Schliffke S,Carambia A,Akyüz N,Thiele B,Herkel J,Binder M

    更新日期：2019-07-15 00:00:00

  • Suppression of experimental autoimmune encephalomyelitis (EAE) by intraperitoneal administration of soluble myelin antigens in Wistar rats.

    abstract：:Intraperitoneal (i.p.) treatment of Wistar rats with bovine myelin (BM) or myelin basic protein (MBP) previously to immunization with BM-CFA showed a diminished incidence and severity of experimental autoimmune encephalomyelitis (EAE) (2/13 and 0/7, respectively) when compared with rats immunized with BM-CFA (11/17) o...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00117-8

    authors： Rivero VE,Maccioni M,Bucher AE,Roth GA,Riera CM

    更新日期：1997-01-01 00:00:00

  • CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.

    abstract：:The role of CD8⁺ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8⁺ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.04.014

    authors： Camara M,Beyersdorf N,Fischer HJ,Herold MJ,Ip CW,van den Brandt J,Toyka KV,Taurog JD,Hünig T,Herrmann T,Reichardt HM,Weishaupt A,Kerkau T

    更新日期：2013-07-15 00:00:00

  • Disturbed in vitro adrenergic modulation of cytokine production in inflammatory bowel diseases in remission.

    abstract：OBJECTIVE:Psychological stress has been implicated in the pathophysiology of both inflammatory and functional gastrointestinal (GI) diseases. The goal of this study was to address neuroendocrine modulation of cytokine production by peripheral blood cells in GI diseases. METHODS:We analyzed the in vitro effects of the ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.09.011

    authors： Lucas A,Cobelens PM,Kavelaars A,Heijnen CJ,Holtmann G,Haag S,Gerken G,Langhorst J,Dobos GJ,Schedlowski M,Elsenbruch S

    更新日期：2007-01-01 00:00:00

  • Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training.

    abstract：:Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jneuroim.2017.12.001

    authors： Bansi J,Koliamitra C,Bloch W,Joisten N,Schenk A,Watson M,Kool J,Langdon D,Dalgas U,Kesselring J,Zimmer P

    更新日期：2018-01-15 00:00:00

  • A possible association between elevated serum levels of brain-specific auto-antibodies and reduced plasma levels of docosahexaenoic acid in autistic children.

    abstract：:Polyunsaturated fatty acids (PUFAs) are not only essential for energy production, but they also exhibit a range of immunomodulatory properties that progress through T cell mediated events. Autoimmunity may have a pathogenic role in a subgroup of autistic children. This study is the first to investigate the relationshi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.01.009

    authors： Mostafa GA,El-Khashab HY,Al-Ayadhi LY

    更新日期：2015-03-15 00:00:00

  • Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis.

    abstract：:Human sera from patients with multiple sclerosis (MS) were tested using an enzyme-linked immunosorbent assay (ELISA) method on well plates coated with various dicarboxylic acid (C4 to C10) protein conjugates. Specific immunological binding was found with an azelaic acid (AzeA, C9) conjugate. The antibody titer was hig...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90043-x

    authors： Daverat P,Geffard M,Orgogozo JM

    更新日期：1989-04-01 00:00:00

  • Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis.

    abstract：:Peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones (TZDs) and 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study ai...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.12.015

    authors： Storer PD,Xu J,Chavis J,Drew PD

    更新日期：2005-04-01 00:00:00

  • Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection.

    abstract：:Multiple sclerosis (MS) is an autoimmune disease associated with environmental factors, possibly including several viruses such as the coronaviruses. Indeed, murine coronavirus (MHV) infection provides a well-known experimental model for MS studies. Intracerebral infection of C57BL/6 mice with MHV-A59 revealed that vi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.01.007

    authors： Gruslin E,Moisan S,St-Pierre Y,Desforges M,Talbot PJ

    更新日期：2005-05-01 00:00:00

  • CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice.

    abstract：:Tumorigenesis requires interactions between tumor progenitors and their microenvironment. We found that low cAMP levels were sufficient for tumorigenesis in a mouse model of Neurofibromatosis-1 (NF1)-associated optic pathway glioma (OPG). We hypothesized that the distinct pattern of glioma in NF1 reflected spatiotempo...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.05.002

    authors： Sun T,Gianino SM,Jackson E,Piwnica-Worms D,Gutmann DH,Rubin JB

    更新日期：2010-07-27 00:00:00

  • The role of regulatory T cells in Lewis rats resistant to EAE.

    abstract：:Adult Lewis (LEW) rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE), induced actively by immunization with guinea pig (GP) myelin basic protein (MBP) in complete Freund's adjuvant or adoptively transferred with activated T lymphocytes reactive to GP MBP peptide 68-88. Once LEW rats recover...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00176-8

    authors： Sun D,Wilson DB,Cao L,Whitaker JN

    更新日期：1998-01-01 00:00:00

  • Antibody neutralization of vascular endothelial growth factor (VEGF) fails to attenuate vascular permeability and brain edema in experimental pneumococcal meningitis.

    abstract：:To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.11.013

    authors： van der Flier M,Coenjaerts FE,Mwinzi PN,Rijkers E,Ruyken M,Scharringa J,Kimpen JL,Hoepelman AI,Geelen SP

    更新日期：2005-03-01 00:00:00

  • Chromosome 7q21-22 and multiple sclerosis: evidence for a genetic susceptibility effect in vicinity to the protachykinin-1 gene.

    abstract：:Chromosome 7q21-22 and, in particular, the region surrounding D7S554 emerged from the recent American genome screen in multiple sclerosis (MS) as the most promising region genome-wide for harboring a disease susceptibility gene. We tested association between D7S554 and MS in 217 Sardinian trio MS families by the trans...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00023-1

    authors： Vandenbroeck K,Fiten P,Heggarty S,Goris A,Cocco E,Hawkins SA,Graham CA,Marrosu MG,Opdenakker G

    更新日期：2002-04-01 00:00:00

  • Major histocompatibility complex class II molecule expression on muscle cells is regulated by differentiation: implications for the immunopathogenesis of muscle autoimmune diseases.

    abstract：:Major histocompatibility complex (MHC) class II molecules are expressed on myoblasts after interferon-gamma (IFN-gamma) treatment, suggesting a muscle cell involvement in antigen presentation in inflammatory myopathies. However, they were not observed on normal or pathological myofibers. This discrepancy might be rela...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(96)00068-9

    authors： Mantegazza R,Gebbia M,Mora M,Barresi R,Bernasconi P,Baggi F,Cornelio F

    更新日期：1996-08-01 00:00:00

  • Experimental autoimmune encephalomyelitis: isolation and characterization of inflammatory cells from the central nervous system.

    abstract：:Lymphocytes from the central nervous system (CNS) of animals with acute experimental autoimmune encephalomyelitis (EAE) have been isolated and characterized. The lymphocytes were separated from Lewis rats which were injected either with an emulsion of myelin basic protein (BP) emulsified in complete Freund's adjuvant ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90137-9

    authors： Lyman WD,Abrams GA,Raine CS

    更新日期：1989-12-01 00:00:00

  • A monoclonal antibody recognizing subpopulations of neurones in mouse brain.

    abstract：:A monoclonal antibody, designated C138, was raised against a particulate fraction from young postnatal mouse cerebellum. In sections from adult mouse brain and cerebellum, this antibody stained a sub-population of neurons. Cell bodies of large neurones and fibre tracts were negative in all brain regions examined, wher...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90034-6

    authors： Hirsch MR,Langley OK,Ghandour MS,Hirn M,Gombos G,Goridis C

    更新日期：1983-06-01 00:00:00

  • Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody.

    abstract：:Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), characterized by progressive weakness associated with robust ITA...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.09.001

    authors： Pachner AR,Brady J,Narayan K

    更新日期：2007-10-01 00:00:00

  • Combination treatment of celecoxib and ciprofloxacin attenuates live S. aureus induced oxidative damage and inflammation in murine microglia via regulation of cytokine balance.

    abstract：:Microglial activation is the most common phenomenon in S. aureus induced brain abscesses as well as other common neurodegenerative diseases. The main objective of this study is to reduce the microglial inflammation with effective bacterial elimination. Ciprofloxacin and celecoxib were used in combination to regulate S...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.12.006

    authors： Dey R,Sultana S,Bishayi B

    更新日期：2018-03-15 00:00:00

  • Early major histocompatibility complex (MHC) class I antigen induction in hypothalamic supraoptic and paraventricular nuclei in trypanosome-infected rats.

    abstract：:Sprague-Dawley rats were injected intraperitoneally with a suspension of Trypanosoma brucei brucei. An early induction of major histocompatibility complex (MHC) class I antigens as well as an infiltration of macrophage-like cells and cytotoxic T-cells was detected with immunohistochemical techniques in circumventricul...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90104-5

    authors： Schultzberg M,Olsson T,Samuelsson EB,Maehlen J,Kristensson K

    更新日期：1989-09-01 00:00:00

  • Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis.

    abstract：:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.08.008

    authors： Marra S,Burnett M,Hoffman-Goetz L

    更新日期：2005-01-01 00:00:00

  • Muscarinic receptor subtypes in subpopulations of human blood mononuclear cells as analyzed by RT-PCR technique.

    abstract：:In this study we have analysed the expression of mRNA encoding the m1-m5 mAChR subtypes in human blood mononuclear cells and subpopulations of lymphocytes using reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Total RNA was extracted from human blood mononuclear cells. T cells, monocytes. EB virus t...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(96)00079-3

    authors： Hellström-Lindahl E,Nordberg A

    更新日期：1996-08-01 00:00:00