Induction of TRAIL-mediated glioma cell death by human T cells.

abstract：:Multiple sclerosis (MS) is a demyelinating disease characterized by the breakdown of the blood-brain barrier (BBB), and accumulation of inflammatory infiltrates in the central nervous system. Tight junctions are specialized cell-cell adhesion structures and critical components of the BBB that have previously been show...

journal_title：Journal of neuroimmunology

authors： Bennett J,Basivireddy J,Kollar A,Biron KE,Reickmann P,Jefferies WA,McQuaid S

更新日期：2010-12-15 00:00:00

abstract：:Lymphocytes from the central nervous system (CNS) of animals with acute experimental autoimmune encephalomyelitis (EAE) have been isolated and characterized. The lymphocytes were separated from Lewis rats which were injected either with an emulsion of myelin basic protein (BP) emulsified in complete Freund's adjuvant ...

journal_title：Journal of neuroimmunology

authors： Lyman WD,Abrams GA,Raine CS

更新日期：1989-12-01 00:00:00

abstract：:Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopme...

journal_title：Journal of neuroimmunology

authors： Kapelski P,Skibinska M,Maciukiewicz M,Pawlak J,Permoda-Osip A,Twarowska-Hauser J

更新日期：2015-08-15 00:00:00

abstract：:PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active ...

journal_title：Journal of neuroimmunology

authors： Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

更新日期：2010-08-25 00:00:00

abstract：:This study explores nasal administration of myelin basic protein (MBP) as a potential means of inducing tolerance to relapsing experimental autoimmune encephalomyelitis (PR-EAE), an experimental multiple sclerosis (MS) model that was induced in DA rats by immunization with rat spinal cord homogenate and incomplete Fre...

journal_title：Journal of neuroimmunology

authors： Bai XF,Shi FD,Xiao BG,Li HL,van der Meide PH,Link H

更新日期：1997-12-01 00:00:00

abstract：:The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo...

journal_title：Journal of neuroimmunology

authors： Jung S,Schluesener HJ,Toyka K,Hartung HP

更新日期：1991-12-01 00:00:00

abstract：:Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

journal_title：Journal of neuroimmunology

authors： Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

更新日期：1989-12-01 00:00:00

abstract：:A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...

journal_title：Journal of neuroimmunology

authors： Doll SC,Johnson TC

更新日期：1989-09-01 00:00:00

abstract：:The human platelet serotonergic responses of aggregation and uptake were shown to be modulated by muramyl peptides. Muramyl dipeptide inhibited serotonin uptake in a temperature dependent and stereospecific manner. It also blocked the binding to platelets of [3H]imipramine, a well-known inhibitor of serotonin uptake. ...

journal_title：Journal of neuroimmunology

authors： Polanski M,Karnovsky ML

更新日期：1992-03-01 00:00:00

abstract：:The microglial inflammatory response to Abeta(1-42) stimulation with or without IFN-gamma priming was investigated in low and high responder strains of mice, A/J and C57BL/6, respectively. A/J microglia showed moderate morphological changes upon stimulation with IFN-gamma alone or with Abeta(1-42). Conversely, C57BL/6...

journal_title：Journal of neuroimmunology

authors： Dudal S,Morissette C,Lacombe D,Tremblay P,Gervais F

更新日期：2004-08-01 00:00:00

abstract：:To study the role of cell adhesion molecules in the fatal CD8+ T-cell mediated meningitis which is induced by intracerebral infection with lymphocytic choriomeningitis virus, the expression of relevant molecules on inflammatory cells and local endothelium was analyzed immunohistochemically. Most inflammatory cells wer...

journal_title：Journal of neuroimmunology

authors： Marker O,Scheynius A,Christensen JP,Thomsen AR

更新日期：1995-10-01 00:00:00

abstract：:Possible mechanisms involved in the protective effect of staphylococcal enterotoxin B (SEB) injection on the subsequent development of experimental autoimmune encephalomyelitis (EAE) were investigated. Only partial clonal deletion and anergy of Vbeta8 + T-lymphocytes were documented after myelin basic protein immuniza...

journal_title：Journal of neuroimmunology

authors： Kuschnaroff LM,Overbergh L,Sefriouni H,Sobis H,Vandeputte M,Waer M

更新日期：1999-10-29 00:00:00

abstract：:The acetylcholine receptor (AChR) is the main target antigen in myasthenia gravis (MG), but about 15% of patients with typical immunologically mediated MG do not have detectable anti-AChR antibodies. Previous studies showed that plasma from these 'seronegative' patients (SNMG) reduced AChR function in the human AChR-e...

journal_title：Journal of neuroimmunology

authors： Li Z,Forester N,Vincent A

更新日期：1996-02-01 00:00:00

abstract：:Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n=44) or Tourette syndrome (n=40) as compared to ...

journal_title：Journal of neuroimmunology

authors： Morris-Berry CM,Pollard M,Gao S,Thompson C,Tourette Syndrome Study Group.,Singer HS

更新日期：2013-11-15 00:00:00

abstract：:To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...

journal_title：Journal of neuroimmunology

authors： Nakajima H,Nakamura Y,Inaba Y,Tsutsumi C,Unoda K,Hosokawa T,Kimura F,Hanafusa T,Date M,Kitaoka H

更新日期：2018-04-15 00:00:00

abstract：:Nitric oxide (NO) is implicated in inflammation and hypothalamic-pituitary responses to immune stimuli; however, the specific role of NO from neurons during stress-induced immune responses remains unspecified. We measured antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and ...

journal_title：Journal of neuroimmunology

authors： Bilbo SD,Hotchkiss AK,Chiavegatto S,Nelson RJ

更新日期：2003-07-01 00:00:00

abstract：:We investigated whether glatiramer acetate (GA) treatment may affect Th1 differentiation at various T-cell maturation stages. Specifically, we analyzed the effect of in vivo GA treatment on intracellular synthesis of IL-2 and TNF-alpha by naive, memory and effector CD4(+) and CD8(+) T cells by five-colour flow cytomet...

journal_title：Journal of neuroimmunology

authors： Kantengwa S,Weber MS,Juillard C,Benkhoucha M,Fellay B,Zamvil SS,Gougeon ML,Chofflon M,Lalive PH

更新日期：2007-04-01 00:00:00

abstract：:IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively...

journal_title：Journal of neuroimmunology

authors： Gruol DL,Puro A,Hao C,Blakely P,Janneke E,Vo K

更新日期：2011-10-28 00:00:00

abstract：:Cells that produce interleukin-6 (IL-6) require the presence of signaling molecules since this cytokine is not normally constitutively expressed. It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. In the cur...

journal_title：Journal of neuroimmunology

authors： Benveniste EN,Sparacio SM,Norris JG,Grenett HE,Fuller GM

更新日期：1990-12-01 00:00:00

abstract：:In order to evaluate changes in lymphocyte subpopulations of cerebrospinal fluid (CSF) cells in neurological diseases, normal control data have to be established. In this study we evaluated CSF samples from 65 dogs of both sexes and various breeds with an age range between 5 months and 6 years, and 20 one-year-old hea...

journal_title：Journal of neuroimmunology

authors： Tipold A,Moore P,Jungi TW,Sager H,Vandevelde M

更新日期：1998-02-01 00:00:00

abstract：:Methadone is known to exert modulatory effects on the immune system. We investigated the potential effects of methadone on infiltration of inflammatory cells into the spinal cord, as well as the proliferative and cytokine responses of T cells in MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice. Met...

journal_title：Journal of neuroimmunology

authors： Kafami L,Etesami I,Felfeli M,Enayati N,Ghiaghi R,Aminian A,Dehpour A

更新日期：2013-02-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

journal_title：Journal of neuroimmunology

authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

更新日期：2004-01-01 00:00:00

abstract：:H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that con...

journal_title：Journal of neuroimmunology

authors： Lavi E,Suzumura A,Murray EM,Silberberg DH,Weiss SR

更新日期：1989-04-01 00:00:00

abstract：:Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease. Here, we report that the sera of MS patien...

journal_title：Journal of neuroimmunology

authors： Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

更新日期：1998-06-15 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) treatment of Alzheimer's disease (AD) has been encouraging. Its mechanism of action might be via anti-β-amyloid (Aβ) antibodies which facilitate Aβ clearance. However, IVIG's benefits might result from its antiviral activity, particularly against herpes simplex virus type 1 (HSV1), a ...

journal_title：Journal of neuroimmunology

authors： Wozniak MA,Itzhaki RF

更新日期：2013-04-15 00:00:00

abstract：:Synthetic peptides of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) were screened for their ability to induce experimental allergic encephalomyelitis (EAE) in ABH (H-2A(g7)) and SJL (H-2(s)) mice. The use of overlapping 16mer...

journal_title：Journal of neuroimmunology

authors： Morris-Downes MM,McCormack K,Baker D,Sivaprasad D,Natkunarajah J,Amor S

更新日期：2002-01-01 00:00:00

abstract：:Naive Th cells obtained from OVA(323-339)-specific DO11.10 TCR-Tg mice did not express preproenkephalin (PPE) mRNA. However, culture of naive Th cells with OVA(323-339) peptide (OVA-pep) plus IL-2 under Th2-inducing conditions for 7 days resulted in an induction of PPE mRNA. The PPE mRNA was also induced by culturing ...

journal_title：Journal of neuroimmunology

authors： Yahata T,Yahata C,Ohta A,Sekimoto M,Kitamura H,Iwakabe K,Habu S,Azuma S,Nakui M,Sato M,Koda T,Nishimura T

更新日期：2000-06-26 00:00:00

abstract：:In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial ...

journal_title：Journal of neuroimmunology

authors： Gallo P,Pagni S,Giometto B,Piccinno MG,Bozza F,Argentiero V,Tavolato B

更新日期：1990-09-01 00:00:00

abstract：:In experimental autoimmune encephalomyelitis (EAE) and other neurodegenerative diseases, astrocytes play an important role in promoting or attenuating the inflammatory response through induction of different cytokines and growth factors. HuR plays a major role in regulating many of these factors by modulating RNA stab...

journal_title：Journal of neuroimmunology

authors： Wheeler C,Nabors LB,Barnum S,Yang X,Hu X,Schoeb TR,Chen D,Ardelt AA,King PH

更新日期：2012-05-15 00:00:00

abstract：:To determine whether TNF and TRAIL death receptors (DR), and decoy receptors (DcR), play a role in oligodendrocyte depletion in the lesions of chronic multiple sclerosis (MS), we investigated the presence and functionality of these molecules on oligodendrocytes in MS and non-MS brain tissue and on human oligodendrocyt...

journal_title：Journal of neuroimmunology

authors： Cannella B,Gaupp S,Omari KM,Raine CS

更新日期：2007-08-01 00:00:00