Serotonergic aspects of the response of human platelets to immune-adjuvant muramyl dipeptide.

abstract：:Melatonin is known as an antistress and immunostimulator compound while glucocorticoids have immunosuppressive function. The mechanism of action of both the hormones on immune cells is still a question. We found that melatonin improved the effect of dexamethasone (synthetic glucocorticoid) induced immunosuppression of...

journal_title：Journal of neuroimmunology

authors： Vishwas DK,Mukherjee A,Haldar C

更新日期：2013-06-15 00:00:00

abstract：:Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

journal_title：Journal of neuroimmunology

authors： Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

更新日期：2001-01-01 00:00:00

abstract：:We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201-216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44-59, induced cross-reactive T cells fo...

journal_title：Journal of neuroimmunology

authors： Gangaplara A,Massilamany C,Steffen D,Reddy J

更新日期：2013-10-15 00:00:00

abstract：:Our work consists of a pilot study to characterize circulating Th/c1, Th/c2, Th/c17, Treg and Tfh-like populations and IL-17 serum levels of relapsing-remitting (RR) MS patients treated with IFN-β, compared with healthy controls. In remission RRMS patients, we observe increased Th/c17 cells frequency committed to a Th...

journal_title：Journal of neuroimmunology

authors： Monteiro A,Rosado P,Rosado L,Fonseca AM,Paiva A

更新日期：2020-02-15 00:00:00

abstract：:Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

journal_title：Journal of neuroimmunology

authors： Schupf N,Williams CA

更新日期：1987-01-01 00:00:00

abstract：:We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8+ (putative suppressor...

journal_title：Journal of neuroimmunology

authors： Lisak RP,Zweiman B,Guerrero F,Moskovitz AR

更新日期：1985-05-01 00:00:00

abstract：:Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively the optic nerve and the spinal cord. It was previously considered to be a severe variant of multiple sclerosis (MS) due to the similar pathological features and its resemblance to optico-spinal, or Japanese, MS, typical of Asian populati...

journal_title：Journal of neuroimmunology

authors： Fazio R,Radaelli M,Furlan R

更新日期：2011-02-01 00:00:00

abstract：:The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulati...

journal_title：Journal of neuroimmunology

authors： Ekerfelt C,Ernerudh J,Forsberg P,Bergström S

更新日期：1998-08-14 00:00:00

abstract：:An epistatic gene interaction has been advocated to explain disease susceptibility in multiple sclerosis (MS). Cytokine genes are possible candidates due to the central role played by cytokines in the regulation of the immune-mediated pathogenetic process leading to central nervous system demyelination in these patien...

journal_title：Journal of neuroimmunology

authors： Vandenbroeck K,Martino G,Marrosu M,Consiglio A,Zaffaroni M,Vaccargiu S,Franciotta D,Ruggeri M,Comi G,Grimaldi LM

更新日期：1997-06-01 00:00:00

abstract：:Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

journal_title：Journal of neuroimmunology

authors： Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

更新日期：2009-05-29 00:00:00

abstract：:Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by priming and tolerising T cells. DC capture and process antigens, express co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. In multiple sclerosis (MS), autoreactive T c...

journal_title：Journal of neuroimmunology

authors： Huang YM,Xiao BG,Ozenci V,Kouwenhoven M,Teleshova N,Fredrikson S,Link H

更新日期：1999-09-01 00:00:00

abstract：:Following axotomy of the facial nerve microglial cells in the facial nucleus become activated, proliferate, and newly express class I and class II major histocompatibility complex (MHC) antigens. Dexamethasone treatment, starting 2 days prior to axotomy at 1 mg/kg/day, selectively inhibited axotomy-induced MHC class I...

journal_title：Journal of neuroimmunology

authors： Kiefer R,Kreutzberg GW

更新日期：1991-11-01 00:00:00

abstract：:To explore the hypothesis that gammadelta T cells may regulate activated alphabeta T cells, we studied gammadelta T cell responses to alphabeta T cell clones in Multiple Sclerosis (MS) patients who received attenuated autologous autoreactive T cells. We recently conducted a pilot study of T cell vaccination with myeli...

journal_title：Journal of neuroimmunology

authors： Stinissen P,Zhang J,Vandevyver C,Hermans G,Raus J

更新日期：1998-07-01 00:00:00

abstract：:The present work examined the effects induced by dibutyryl cyclic adenosine monophosphate (dB-cAMP) on microglial cells in primary glial cell cultures from newborn rats. Microglial cells were identified by OX42 immunohistochemistry and nucleoside diphosphatase histochemistry. Double staining for astrocytes was carried...

journal_title：Journal of neuroimmunology

authors： Dalmau I,Castellano B,Pedersen EB,Finsen B,Zimmer J,González B

更新日期：1996-11-01 00:00:00

abstract：:Neuroendocrine system and immune system can communicate via the use of soluble mediators like hormones, neurotransmitters and cytokines. The level of mediators secreted by either of these systems creates the milieu in which immune and neuroendocrine responses take place. For adequate communication between the systems,...

journal_title：Journal of neuroimmunology

authors： Heijnen CJ,Kavelaars A

更新日期：1999-12-01 00:00:00

abstract：:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

journal_title：Journal of neuroimmunology

authors： Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

更新日期：2005-10-01 00:00:00

abstract：:Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared ...

journal_title：Journal of neuroimmunology

authors： Mutnal MB,Cheeran MC,Hu S,Little MR,Lokensgard JR

更新日期：2010-10-08 00:00:00

abstract：:Dendritic cells (DCs) are key regulators of immune responses and have been associated with autoimmunity in animal models and human disease. The effects of interferon beta (IFN-beta), an immunomodulatory cytokine used in multiple sclerosis (MS) therapy, on DCs are not well understood. Monocyte-derived DCs at different ...

journal_title：Journal of neuroimmunology

authors： Wiesemann E,Sönmez D,Heidenreich F,Windhagen A

更新日期：2002-02-01 00:00:00

abstract：:Using simultaneous dual direct immunofluorescence the effect of high dose intravenous methylprednisolone on the expression of T lymphocyte differentiation antigens in paired cerebrospinal fluid and peripheral blood samples of nine clinically active patients with multiple sclerosis was studied. Corticosteroid treatment...

journal_title：Journal of neuroimmunology

authors： Durelli L,Poccardi G,Cavallo R

更新日期：1991-03-01 00:00:00

abstract：:Inflammatory mediators are involved in the pathogenesis of focal ischemic brain damage. In this study we used quantitative reverse transcriptase-polymerase chain reaction to analyze the spatiotemporal pattern of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and inducible nitric oxide synthase ...

journal_title：Journal of neuroimmunology

authors： Jander S,Schroeter M,Stoll G

更新日期：2000-09-22 00:00:00

abstract：:CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response and establishing immunological tolerance. We report that in the normal human brain CCL19, but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in cerebrospinal fluid. In both active and inactive multiple scl...

journal_title：Journal of neuroimmunology

authors： Krumbholz M,Theil D,Steinmeyer F,Cepok S,Hemmer B,Hofbauer M,Farina C,Derfuss T,Junker A,Arzberger T,Sinicina I,Hartle C,Newcombe J,Hohlfeld R,Meinl E

更新日期：2007-10-01 00:00:00

abstract：:This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less s...

journal_title：Journal of neuroimmunology

authors： Aharoni R,Aricha R,Eilam R,From I,Mizrahi K,Arnon R,Souroujon MC,Fuchs S

更新日期：2013-09-15 00:00:00

abstract：:We analyzed the characteristics of 29 Guillain-Barré syndrome (GBS) patients with IgM anti-GalNAc-GD1a antibodies. Fourteen of them had had an antecedent cytomegalovirus infection (CMV group) and 12 gastrointestinal infection (G-I group). Most of the G-I group patients (nine of 12) were subsequent to Campylobacter jej...

journal_title：Journal of neuroimmunology

authors： Kaida K,Kusunoki S,Kamakura K,Motoyoshi K,Kanazawa I

更新日期：2001-02-15 00:00:00

abstract：:The two chemokines, monocyte chemoattractant protein (MCP)-1 and gamma-interferon inducible protein (IP)-10, are thought to be involved in the pathogenesis of multiple sclerosis (MS). We measured MCP-1 and IP-10 levels in serum and CSF samples from 38 acute and 25 stable MS patients and from 40 controls. The latter co...

journal_title：Journal of neuroimmunology

authors： Franciotta D,Martino G,Zardini E,Furlan R,Bergamaschi R,Andreoni L,Cosi V

更新日期：2001-04-02 00:00:00

abstract：:The acetylcholine receptor (AChR) is the main target antigen in myasthenia gravis (MG), but about 15% of patients with typical immunologically mediated MG do not have detectable anti-AChR antibodies. Previous studies showed that plasma from these 'seronegative' patients (SNMG) reduced AChR function in the human AChR-e...

journal_title：Journal of neuroimmunology

authors： Li Z,Forester N,Vincent A

更新日期：1996-02-01 00:00:00

abstract：:Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerab...

journal_title：Journal of neuroimmunology

authors： Wildner P,Selmaj KW

更新日期：2017-10-15 00:00:00

abstract：:Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patien...

journal_title：Journal of neuroimmunology

authors： Strunk D,Schulte-Mecklenbeck A,Golombeck KS,Meyer Zu Hörste G,Melzer N,Beuker C,Schmidt A,Wiendl H,Meuth SG,Gross CC,Minnerup J

更新日期：2018-08-15 00:00:00

abstract：:Rat thymocytes incubated in RPMI medium for 120-300 min release a soluble factor of molecular weight below 10,000 Da which inhibits the binding of 3H-labeled muscarinic antagonists in an uncompetitive manner, i.e. it reduces maximal specific binding (Bmax) without changing the affinity of the ligand (KD). This factor ...

journal_title：Journal of neuroimmunology

authors： Maslinski W,Ryzewski J,Bartfai T

更新日期：1988-03-01 00:00:00

abstract：:Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish popula...

journal_title：Journal of neuroimmunology

authors： Mirowska-Guzel D,Gromadzka G,Mach A,Czlonkowski A,Czlonkowska A

更新日期：2011-07-01 00:00:00

abstract：:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

journal_title：Journal of neuroimmunology

authors： Tsunoda I,Libbey JE,Fujinami RS

更新日期：2007-08-01 00:00:00