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Immune cell profiling in the cerebrospinal fluid of patients with primary angiitis of the central nervous system reflects the heterogeneity of the disease.

Abstract：

:Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patients with multiple sclerosis, ischemic stroke, and somatoform disorders (n = 18 per group). Changes in the intrathecal immune-cell profile were heterogeneous in PACNS. While proportions of T-cell subsets remained unaltered, some PACNS patients showed a shift toward NK- or B cells. Intrathecal immunoglobulin synthesis was observed in a subgroup of PACNS patients with an increased frequency of antibody producing plasma cells.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Strunk D,Schulte-Mecklenbeck A,Golombeck KS,Meyer Zu Hörste G,Melzer N,Beuker C,Schmidt A,Wiendl H,Meuth SG,Gross CC,Minnerup J

doi

10.1016/j.jneuroim.2018.06.004

subject

Has Abstract

pub_date

2018-08-15 00:00:00

pages

109-116

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30165-6

journal_volume

321

pub_type

杂志文章

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