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Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment.

Abstract：

:HIV-associated cognitive neurological disorders (HAND) prevail in the antiretroviral therapy era. Proteomics analysis of CSF revealed expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) in Hispanic women with cognitive impairment (CI). We tested the hypothesis that there is reduced capacity of antioxidant enzymes in CI by measures of expression and activity of Cu/Zn SOD, catalase, and Se-glutathione peroxidase in HAND. Our results showed that the function of these antioxidants was decreased in the CSF and monocytes of women with CI. These findings have important implications regarding their possible contribution to oxidative stress and in the diagnosis and therapy for HAND.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Velázquez I,Plaud M,Wojna V,Skolasky R,Laspiur JP,Meléndez LM

doi

10.1016/j.jneuroim.2008.10.013

subject

Has Abstract

pub_date

2009-01-03 00:00:00

pages

106-11

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00454-2

journal_volume

206

pub_type

杂志文章

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