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Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.

Abstract：

:Inflammation in the meninges, tissues surrounding the brain and spinal cord that enclose the cerebrospinal fluid, closely parallels clinical exacerbations in relapsing-remitting experimental autoimmune encephalomyelitis (EAE). In preclinical disease, an influx of innate immune cells precedes loss of blood brain barrier (BBB) integrity and large-scale inflammation in the central nervous system (CNS). T cell infiltration into the meninges is observed in acute disease as well as during relapse, when neither BBB permeability nor significant increases in peripherally-derived immune cell numbers in the CNS are observed. These findings support the idea that the meninges are a gateway for immune cell access into the CNS, a finding that has important therapeutic implications.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Walker-Caulfield ME,Hatfield JK,Brown MA

doi

10.1016/j.jneuroim.2014.12.009

subject

Has Abstract

pub_date

2015-01-15 00:00:00

pages

112-22

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(14)00993-X

journal_volume

278

pub_type

杂志文章

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