The C5a complement activation peptide increases IL-1beta and IL-6 release from amyloid-beta primed human monocytes: implications for Alzheimer's disease.

Abstract:

:Alzheimer's disease (AD) brains contain large numbers of amyloid-beta peptide (Abeta) deposits associated with activated microglia, astrocytes and dystrophic neurites. Activated complement components and pro-inflammatory cytokines are also present, indicative of focal inflammation. However, neither Abeta, nor the chemokine-like mediator, C5a, which is generated by Abeta-mediated complement activation, significantly activates microglia, as assessed by pro-inflammatory cytokine release. We evaluated the possibility that both together would co-stimulate such release using the THP-1 human monocytic cell line as a microglial surrogate, and found this to be the case. These studies support the hypothesis that Abeta and C5a induce a chronic microglia-mediated focal inflammatory response in AD.

journal_name

J Neuroimmunol

authors

O'Barr S,Cooper NR

doi

10.1016/s0165-5728(00)00291-5

subject

Has Abstract

pub_date

2000-09-22 00:00:00

pages

87-94

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572800002915

journal_volume

109

pub_type

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