Abstract:
:Alzheimer's disease (AD) brains contain large numbers of amyloid-beta peptide (Abeta) deposits associated with activated microglia, astrocytes and dystrophic neurites. Activated complement components and pro-inflammatory cytokines are also present, indicative of focal inflammation. However, neither Abeta, nor the chemokine-like mediator, C5a, which is generated by Abeta-mediated complement activation, significantly activates microglia, as assessed by pro-inflammatory cytokine release. We evaluated the possibility that both together would co-stimulate such release using the THP-1 human monocytic cell line as a microglial surrogate, and found this to be the case. These studies support the hypothesis that Abeta and C5a induce a chronic microglia-mediated focal inflammatory response in AD.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
O'Barr S,Cooper NRdoi
10.1016/s0165-5728(00)00291-5subject
Has Abstractpub_date
2000-09-22 00:00:00pages
87-94issue
2eissn
0165-5728issn
1872-8421pii
S0165572800002915journal_volume
109pub_type
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