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Possible significance of anti-heat shock protein (HSP-65) antibodies in autoimmune myasthenia gravis.

Abstract：

:Myasthenia gravis (MG) is an autoimmune disorder caused by antibody-mediated attack against skeletal muscle nicotinic acetylcholine receptor (AchR) at neuromuscular junction. A close relationship exists between heat shock proteins (HSPs) and numerous autoimmune diseases. HSPs are over expressed to protect the host against various insults. Antibodies to HSP-65 (IgG, IgA, IgM) are evaluated in 40 MG sera by ELISA. About 80% of MG cases showed anti-HSP antibodies (62.5% IgG, 55% IgA, 40% IgM). The result suggests that, expression of HSP-65 increases in MG and most individuals produce antibodies to it. These antibodies might play a significant role in the pathogenesis of MG.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Patil SA,Katyayani S,Sood A,Kavitha AK,Marimuthu P,Taly AB

doi

10.1016/j.jneuroim.2013.02.001

subject

Has Abstract

pub_date

2013-04-15 00:00:00

pages

107-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00028-3

journal_volume

257

pub_type

杂志文章

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