Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity.

abstract：:Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

journal_title：Journal of neuroimmunology

authors： Correale J,Bassani Molinas Mde L

更新日期：2003-07-01 00:00:00

abstract：:This study aimed to evaluate the effects of leptin, ghrelin and neuropeptide-Y on the development of nonconvulsive seizure activity and their role on combating oxidative stress and cytokines produced by the systemic immune response in the WAG/Rij rat model for genetic absence epilepsy. Current study showed that all th...

journal_title：Journal of neuroimmunology

authors： Oztas B,Sahin D,Kir H,Kuskay S,Ates N

更新日期：2021-02-15 00:00:00

abstract：:Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by broadening of the autoimmune reportoire. Despite epitope spreading to...

journal_title：Journal of neuroimmunology

authors： Smith PA,Morris-Downes M,Heijmans N,Pryce G,Arter E,O'Neill JK,'t Hart B,Baker D,Amor S

更新日期：2005-07-01 00:00:00

abstract：:The cytokine interleukin-1 (IL-1) is involved in a wide range of inflammatory and immune responses. As such, IL-1 could play a role in peripheral nerve repair mechanisms. Specifically, by its already established properties as a regulator of nerve growth factor (NGF) synthesis, and as a chemotactant to macrophages. We ...

journal_title：Journal of neuroimmunology

authors： Rotshenker S,Aamar S,Barak V

更新日期：1992-07-01 00:00:00

abstract：:Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

journal_title：Journal of neuroimmunology

authors： Schupf N,Williams CA

更新日期：1987-01-01 00:00:00

abstract：:In this report, we have shown the expression of the complement regulatory proteins decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 on human D54-MG astroglioma cells by several methods, including immunofluorescence, flow cytometry and Western blotting and Northern blot analysis. Th...

journal_title：Journal of neuroimmunology

authors： Yang C,Jones JL,Barnum SR

更新日期：1993-09-01 00:00:00

abstract：:Employing immunohistochemical techniques and a panel of monoclonal antibodies that recognize rat cells of monocyte/macrophage lineage, we have demonstrated that cells labeled with these antibodies are widely distributed throughout the parenchyma of the rat brain. These cells have a remarkable microglial morphology and...

journal_title：Journal of neuroimmunology

authors： Honda H,Kimura H,Silvers WK,Rostami A

更新日期：1990-09-01 00:00:00

abstract：:Plasma B cells secrete immunoglobulinfree light chains (IgLC) which by binding to mast cells can mediate hypersensitivity responses and are involved in several immunological disorders. To investigate the effects of antigen-specific IgLC activation, intracellular recordings were made from cultured murine dorsal root ga...

journal_title：Journal of neuroimmunology

authors： Rijnierse A,Kraneveld AD,Salemi A,Zwaneveld S,Goumans AP,Rychter JW,Thio M,Redegeld FA,Westerink RH,Kroese AB

更新日期：2013-11-15 00:00:00

abstract：:B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces p...

journal_title：Journal of neuroimmunology

authors： Begum-Haque S,Sharma A,Christy M,Lentini T,Ochoa-Reparaz J,Fayed IF,Mielcarz D,Haque A,Kasper LH

更新日期：2010-02-26 00:00:00

abstract：:Interleukin (IL)-10 is an anti-inflammatory cytokine that can down-regulate various aspects of the immune response. In this study we demonstrate that exposure to a psychophysiological stressor (swim stress) increases IL-10 production in female rats in response to an in vivo challenge with bacterial lipopolysaccharide ...

journal_title：Journal of neuroimmunology

authors： Connor TJ,Brewer C,Kelly JP,Harkin A

更新日期：2005-02-01 00:00:00

abstract：:Alzheimer's disease (AD) brains contain large numbers of amyloid-beta peptide (Abeta) deposits associated with activated microglia, astrocytes and dystrophic neurites. Activated complement components and pro-inflammatory cytokines are also present, indicative of focal inflammation. However, neither Abeta, nor the chem...

journal_title：Journal of neuroimmunology

authors： O'Barr S,Cooper NR

更新日期：2000-09-22 00:00:00

abstract：:We studied the effect of interferons on the expression of class II histocompatibility (HLA-DR) antigens by cultured adult human astrocytes. Cultures were derived from brain tissue resected for surgical treatment of intractable epilepsy. Cultured astrocytes did not spontaneously display HLA-DR antigen as determined by ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Chou SM,Jacobs B,Yen-Lieberman B,Ransohoff RM

更新日期：1989-06-01 00:00:00

abstract：:The acetylcholine receptor (AChR) is the main target antigen in myasthenia gravis (MG), but about 15% of patients with typical immunologically mediated MG do not have detectable anti-AChR antibodies. Previous studies showed that plasma from these 'seronegative' patients (SNMG) reduced AChR function in the human AChR-e...

journal_title：Journal of neuroimmunology

authors： Li Z,Forester N,Vincent A

更新日期：1996-02-01 00:00:00

abstract：:In the present work we investigated on rat splenocytes long-term interactions between opioid and cannabinoid drugs in terms of a common regulation of cAMP intracellular pathway. Both morphine and the synthetic cannabinoid compound CP-55,940 inhibited in a concentration-dependent manner the intracellular cAMP level in ...

journal_title：Journal of neuroimmunology

authors： Massi P,Vaccani A,Rubino T,Parolaro D

更新日期：2003-12-01 00:00:00

abstract：:Opioid-containing immunocytes migrate to inflamed sites where they release beta-endorphin which activates peripheral opioid receptors and produces analgesia. The immigration of immunocytes to sites of inflammation is mediated by adhesion molecules. In this study, the expression of L-, P-, E-selectin and platelet-endot...

journal_title：Journal of neuroimmunology

authors： Mousa SA,Machelska H,Schäfer M,Stein C

更新日期：2000-08-01 00:00:00

abstract：:Autoantibodies which bind to integral membrane proteins of brain were tested for their ability to bind to cross-reactive antigens on non-neural tissue. Both brain specific autoantibodies and antibodies which bind to cross-reactive antigens were found. There were two types of brain reactive autoantibodies which could n...

journal_title：Journal of neuroimmunology

authors： Hoffman SA,Madsen CS

更新日期：1990-12-01 00:00:00

abstract：:In previous work on sigma (sigma) receptors, we established a hybridoma cell line, 10G9, producing a monoclonal anti-idiotypic antibody (anti-Id mAb) to the monoclonal and anti-haloperidol antibody. The anti-Id mAb showed specific binding affinity to sigma receptors in immunoprecipitation and competition experiments. ...

journal_title：Journal of neuroimmunology

authors： Kobayashi T,Togashi S,Itoh N,Kumanishi T

更新日期：1995-03-01 00:00:00

abstract：:Mutations in the GBA gene are related to an increased risk of developing neurodegenerative diseases. The exact molecular mechanisms involved in the interaction between GBA and α-synuclein, a protein that has been associated with several neurological diseases, remain unsolved. Brain-derived neurotrophic factor (BDNF) i...

journal_title：Journal of neuroimmunology

authors： Vairo F,Sperb-Ludwig F,Wilke M,Michellin-Tirelli K,Netto C,Neto EC,Doederlein Schwartz IV

更新日期：2015-01-15 00:00:00

abstract：:This study was aimed at (i) comparison of the usefulness of serum protein oxidation parameters for assessment of oxidative stress (OS) in multiple sclerosis (MS), and (ii) comparison of OS in MS patients subject to various therapies. Elevated glycophore level was noted in relapsing-remitting (RRMS) patients without tr...

journal_title：Journal of neuroimmunology

authors： Sadowska-Bartosz I,Adamczyk-Sowa M,Gajewska A,Bartosz G

更新日期：2014-01-15 00:00:00

abstract：:Immunofluorescence, cell binding assays and enzyme immunoassays were used to investigate the expression of class II major histocompatibility antigens on peripheral blood monocytes in 67 patients with multiple sclerosis. Monocytes from patients with active disease expressed fewer HLA-DR molecules on their surface than ...

journal_title：Journal of neuroimmunology

authors： Baxevanis CN,Reclos GJ,Arsenis P,Anastasopoulos E,Katsiyiannis A,Lymberi P,Matikas N,Papamichail M

更新日期：1989-05-01 00:00:00

abstract：:Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antige...

journal_title：Journal of neuroimmunology

authors： Hohlfeld R,Toyka KV

更新日期：1985-08-01 00:00:00

abstract：:The role of nitric oxide (NO) in central nervous system (CNS) inflammation is uncertain. Whereas experimental autoimmune encephalomyelitis (EAE) is exacerbated in mice deficient in inducible nitric oxide synthase (iNOS), inhibitor studies have suggested a pro-inflammatory role for NO. These discrepancies may reflect b...

journal_title：Journal of neuroimmunology

authors： Zehntner SP,Bourbonniere L,Hassan-Zahraee M,Tran E,Owens T

更新日期：2004-05-01 00:00:00

abstract：:Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the activation loop of ...

journal_title：Journal of neuroimmunology

authors： Jager LD,Dabelic R,Waiboci LW,Lau K,Haider MS,Ahmed CM,Larkin J 3rd,David S,Johnson HM

更新日期：2011-03-01 00:00:00

abstract：:Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that T...

journal_title：Journal of neuroimmunology

authors： Huang Q,Ma X,Zhu DL,Chen L,Jiang Y,Zhou L,Cen L,Pi R,Chen X

更新日期：2015-07-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with myelin basic protein (MBP) and adjuvants. Rats were treated with second daily injections of saline or cyclosporin A (CsA) from the day of inoculation. Saline-treated rats had an acute episode of disease followed by clinical r...

journal_title：Journal of neuroimmunology

authors： McCombe PA,Harness J,Pender MP

更新日期：1999-06-01 00:00:00

abstract：:A high proportion of peptide 1-11 specific T cells from H-2u (V beta 8+, H-2u) mice express the V beta 8 TCR chain. Peptide 89-101 is immunodominant for B10.RIII (V beta 8+, H-2r) mice; thus, it was of interest to determine whether V beta 8 TCR would be over-represented in a population of peptide 89-101-specific T cel...

journal_title：Journal of neuroimmunology

authors： Zhao ML,Xia JQ,Fritz RB

更新日期：1993-02-01 00:00:00

abstract：:An important extrahepatic consequence of Hepatitis C is its adverse impact on the central nervous system and cognitive performance. We aimed to determine whether there is a significant relationship between selected neurotransmitters and cytokines and cognitive performance in patients with Chronic Hepatitis C before an...

journal_title：Journal of neuroimmunology

authors： Weinstein AA,Estep JM,de Avila L,Curry M,Golabi P,Escheik C,Birerdinc A,Stepanova M,Price JK,Gerber L,Younossi ZM

更新日期：2019-10-15 00:00:00

abstract：:Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesi...

journal_title：Journal of neuroimmunology

authors： Kazarian M,Calbo J,Proost N,Carpenter CL,Berns A,Laird-Offringa IA

更新日期：2009-12-10 00:00:00

abstract：:In this report, the role of STAT4 and local production of interleukin (IL)-12 in the central nervous system (CNS) were examined during experimental vesicular stomatitis virus (VSV) encephalitis. We have previously shown that IL-12 treatment is beneficial both in vitro and in vivo during experimental VSV infection. Thi...

journal_title：Journal of neuroimmunology

authors： Chesler DA,Reiss CS

更新日期：2002-10-01 00:00:00

abstract：:Intrathecal Immunoglobulin G (IgG) is elevated in some central nervous system (CNS) diseases and microglia upregulate Fcγ receptors in various neurological disorders. However, the interaction between IgG or IgG immune complexes and microglial Fcγ receptors is not fully understood. In this study, the effect of IgG(1) i...

journal_title：Journal of neuroimmunology

authors： Parajuli B,Sonobe Y,Kawanokuchi J,Doi Y,Noda M,Takeuchi H,Mizuno T,Suzumura A

更新日期：2012-03-01 00:00:00