Molecular cloning of cDNAs for immunoglobulin variable regions of a monoclonal anti-idiotypic antibody specific for sigma receptors.

abstract：:Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu...

journal_title：Journal of neuroimmunology

authors： Matsuoka E,Usuku K,Jonosono M,Takenouchi N,Izumo S,Osame M

更新日期：2000-01-03 00:00:00

abstract：:G-protein-coupled receptors (GPCR) play an important role in inflammation. Their responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and beta-arrestins. We show here that induction of experimental autoimmune encephalomyelitis (EAE) by myelin oligodendrocyte glycoprotein (MOG) resulted in a profoun...

journal_title：Journal of neuroimmunology

authors： Vroon A,Lombardi MS,Kavelaars A,Heijnen CJ

更新日期：2003-04-01 00:00:00

abstract：:Lymphocytic choriomeningitis virus (LCMV) induces a chronic, wasting syndrome when injected intracerebrally into H-2b mice homozygous for a beta 2-microglobulin (beta 2-m (-/-)) gene disruption. These mice have very few CD8+ T cells and express little class I MHC glycoprotein, though minimal levels of the H-2Db molecu...

journal_title：Journal of neuroimmunology

authors： Doherty PC,Hou S,Southern PJ

更新日期：1993-07-01 00:00:00

abstract：:Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two pat...

journal_title：Journal of neuroimmunology

authors： Maddison P,Sadalage G,Ambrose PA,Jacob S,Vincent A

更新日期：2019-07-15 00:00:00

abstract：:Opsoclonus myoclonus ataxia syndrome (OMAS) is an autoimmune disorder characterized by rapid, random, conjugate eye movements (opsoclonus), myoclonus, and ataxia. Given these symptoms, autoantibodies targeting the cerebellum or brainstem could mediate the disease or be markers of autoimmunity. In a subset of patients ...

journal_title：Journal of neuroimmunology

authors： Panzer JA,Anand R,Dalmau J,Lynch DR

更新日期：2015-09-15 00:00:00

abstract：:We recently showed that MMP-9 activity was detectable in the cerebrospinal fluid (CSF) of about half of neurologically symptomatic HIV-infected patients. Using an experimental animal model, we detected MMP-9 activity in CSF samples from rats that had been injected intracisternally with recombinant HIV-1 Nef protein, b...

journal_title：Journal of neuroimmunology

authors： Sporer B,Koedel U,Paul R,Kohleisen B,Erfle V,Fontana A,Pfister HW

更新日期：2000-01-24 00:00:00

abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

更新日期：2001-09-03 00:00:00

abstract：:The key role of an inhibitory receptor, Programmed Death-1, has been evaluated in 273 patients with autoimmune myasthenia gravis. At the genetic level, SNP's genotyping showed no significant association to the disease. Gene expressions in patients were not different from that in controls. Interestingly, at the cell-su...

journal_title：Journal of neuroimmunology

authors： Sakthivel P,Ramanujam R,Wang XB,Pirskanen R,Lefvert AK

更新日期：2008-01-01 00:00:00

abstract：:The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo...

journal_title：Journal of neuroimmunology

authors： Jung S,Schluesener HJ,Toyka K,Hartung HP

更新日期：1991-12-01 00:00:00

abstract：:Recent evidence supports the possible involvement of myelin basic protein (BP) as one of the target autoantigens in multiple sclerosis (MS), including elevated frequencies of MS blood and cerebrospinal fluid (CSF) T cells, and the presence in MS plaque tissue of V beta gene sequences and CDR3 motifs characteristic of ...

journal_title：Journal of neuroimmunology

authors： Satyanarayana K,Chou YK,Bourdette D,Whitham R,Hashim GA,Offner H,Vandenbark AA

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:Our aim was to investigate the correlation between onset age, clinical features and HLA-DQA1/DQB1 genetic variability in myasthenia gravis (MG) patients in Southern Han Chinese. METHODS:205 MG patients and 100 controls were genotyped for HLA-DQA1 and -DQB1 using sequence-based typing (SBT) and analyzed for h...

journal_title：Journal of neuroimmunology

authors： Zhu WH,Lu JH,Lin J,Xi JY,Lu J,Luo SS,Qiao K,Xiao BG,Lu CZ,Zhao CB

更新日期：2012-06-15 00:00:00

abstract：OBJECTIVES:We previously found that antibodies in Tourette's syndrome (TS) patients' sera reacted with a 120 kDa protein from rat brain tissue. Here, we sought to identify this protein and determine if it was involved in TS pathogenesis. METHODS:The 120 kDa protein was identified using immunoprecipitation, Western blo...

journal_title：Journal of neuroimmunology

authors： Yeh CB,Shui HA,Chu TH,Chen YA,Tsung HC,Shyu JF

更新日期：2012-09-15 00:00:00

abstract：:Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the...

journal_title：Journal of neuroimmunology

authors： Laman JD,van Meurs M,Schellekens MM,de Boer M,Melchers B,Massacesi L,Lassmann H,Claassen E,Hart BA

更新日期：1998-06-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we foun...

journal_title：Journal of neuroimmunology

authors： Lv Z,Shi Q,Huang W,Xing C,Hao Y,Feng X,Yang Y,Zhang A,Kong Q,Yuki N,Wang Y

更新日期：2016-12-15 00:00:00

abstract：:Resident glial cells and invading inflammatory cells are responsible for cytokine production within the brain. Astrocytes are known to secrete a variety of cytokines upon stimulation with cytokines themselves, protein kinase C activators, bacterial or viral constituents. Astrocytes also have surface receptors for a wi...

journal_title：Journal of neuroimmunology

authors： Maimone D,Cioni C,Rosa S,Macchia G,Aloisi F,Annunziata P

更新日期：1993-08-01 00:00:00

abstract：:The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high mole...

journal_title：Journal of neuroimmunology

authors： Akeson R,Graham K

更新日期：1981-09-01 00:00:00

abstract：:We examined immune function and changes in T cell populations over a 1-year period in a series of progressive multiple sclerosis (MS) patients treated with different regimens of cyclophosphamide/ACTH as part of the Northeast Multiple Sclerosis Treatment Group. Our studies were designed to determine the effect of diffe...

journal_title：Journal of neuroimmunology

authors： Hafler DA,Orav J,Gertz R,Stazzone L,Weiner HL

更新日期：1991-05-01 00:00:00

abstract：:Neuroendocrine system and immune system can communicate via the use of soluble mediators like hormones, neurotransmitters and cytokines. The level of mediators secreted by either of these systems creates the milieu in which immune and neuroendocrine responses take place. For adequate communication between the systems,...

journal_title：Journal of neuroimmunology

authors： Heijnen CJ,Kavelaars A

更新日期：1999-12-01 00:00:00

abstract：:Transection of the rat facial nerve leads to an intrinsic microglial reaction in the facial nucleus. In the present study, we have examined immunocytochemically the expression of cell adhesion molecules during this process. Resting microglia constitutively expressed the LFA-1 alpha and beta chain (CD11a and CD18) in t...

journal_title：Journal of neuroimmunology

authors： Moneta ME,Gehrmann J,Töpper R,Banati RB,Kreutzberg GW

更新日期：1993-06-01 00:00:00

abstract：:CR-EAE is a Th1-mediated inflammatory autoimmune demyelinating disease of the CNS and serves as a model of human multiple sclerosis. Our previous studies have shown the protective effect of orally administered lisofylline in the prevention of active and passively induced acute EAE. In our present studies we have exami...

journal_title：Journal of neuroimmunology

authors： Du C,Cooper JC,Klaus SJ,Sriram S

更新日期：2000-10-02 00:00:00

abstract：:Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown. The level of plasma Chit activity positively correlates with Alzheimer's disea...

journal_title：Journal of neuroimmunology

authors： Sotgiu S,Musumeci S,Marconi S,Gini B,Bonetti B

更新日期：2008-06-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). To better understand the mechanism of disease relapse, we induced acute and chronic ...

journal_title：Journal of neuroimmunology

authors： Jee Y,Yoon WK,Okura Y,Tanuma N,Matsumoto Y

更新日期：2002-07-01 00:00:00

abstract：:Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T ...

journal_title：Journal of neuroimmunology

authors： Kumar MM,Venkataswamy MM,Sathyanarayanan G,Thippeswamy H,Chandra PS,Mani RS

更新日期：2017-09-15 00:00:00

abstract：:Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors an...

journal_title：Journal of neuroimmunology

authors： Kawano M,Takagi R,Kaneko A,Matsushita S

更新日期：2015-12-15 00:00:00

abstract：:The extent to which symptomatic improvement in patients with multiple sclerosis treated with intravenous methylprednisolone depends on immunological actions of corticosteroids is unknown. In this study the effect of methylprednisolone on circulating T and B cell function has been assessed in vitro and in vivo. Low mol...

journal_title：Journal of neuroimmunology

authors： Kirk P,Compston A

更新日期：1990-01-01 00:00:00

abstract：:The mechanism behind the association between MHC genes and myasthenia gravis (MG) is not fully understood. In the present study we studied the associations with polymorphisms at HLA-DR3, HLA-B8 and TNF-alpha genes in Swedish patients and healthy individuals. The TNF-alpha-308 allele 2 was associated with female patien...

journal_title：Journal of neuroimmunology

authors： Huang DR,Pirskanen R,Matell G,Lefvert AK

更新日期：1999-02-01 00:00:00

abstract：:Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal nec...

journal_title：Journal of neuroimmunology

authors： Horváth E,Huțanu A,Chiriac L,Dobreanu M,Orădan A,Nagy EE

更新日期：2018-11-15 00:00:00

abstract：:Peptide p259-271 of the human acetylcholine receptor alpha-subunit, preferentially stimulates T cells of patients with myasthenia gravis (MG) and is an immunodominant epitope for T cells of BALB/c mice. A p259-271 specific T cell line of BALB/c origin was established and was shown to induce experimental MG in naive mi...

journal_title：Journal of neuroimmunology

authors： Katz-Levy Y,Dayan M,Wirguin I,Fridkin M,Sela M,Mozes E

更新日期：1998-05-01 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are not only essential for energy production, but they also exhibit a range of immunomodulatory properties that progress through T cell mediated events. Autoimmunity may have a pathogenic role in a subgroup of autistic children. This study is the first to investigate the relationshi...

journal_title：Journal of neuroimmunology

authors： Mostafa GA,El-Khashab HY,Al-Ayadhi LY

更新日期：2015-03-15 00:00:00

abstract：:Multiple sclerosis affects more women than men. The reasons for this are unknown. Previously, we have shown significant differences in women versus men in inflammatory cytokine responses to the major protein component of myelin, proteolipid protein (PLP), which is thought to be a target in MS patients. Here, using the...

journal_title：Journal of neuroimmunology

authors： Moldovan IR,Cotleur AC,Zamor N,Butler RS,Pelfrey CM

更新日期：2008-01-01 00:00:00