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CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP.

Abstract：

:Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immune response. Human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is caused by HTLV-I infection and characterized by spastic paraparesis and urinary disturbance with perivascular HTLV-I-infected and activated CD4+ T-cell infiltration. In order to explore the underlying mechanism causing the disease after HTLV-I infection, we analyzed CD44 variant expression on peripheral blood mononuclear cells (PBMC) and in the spinal cord specimens from patients with HAM/TSP, and compared them with those from other HTLV-I-infected individuals and controls. We found that v6v expression with special direct link of exons 10 (v6) and 14(v10) was highly expressed in PBMC from patients with HAM/TSP and that v6v and CD4 double positive T-cell infiltration into the spinal cord lesion of HAM/TSP. This combination of CD44 splice variant has not been previously reported in the study of chronic inflammatory disorders and may be a marker molecule for T-cells infiltrating into the central nervous system (CNS), especially the spinal cord.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Matsuoka E,Usuku K,Jonosono M,Takenouchi N,Izumo S,Osame M

doi

10.1016/s0165-5728(99)00155-1

subject

Has Abstract

pub_date

2000-01-03 00:00:00

pages

1-7

issue

1

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(99)00155-1

journal_volume

102

pub_type

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