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Granulocyte-macrophage colony-stimulating factor as a mediator of autoimmunity in multiple sclerosis.

Abstract：

:Autoreactive, myelin-specific, CD4+ T cells have a central role in multiple sclerosis (MS) pathogenesis; however the exact phenotype characteristics of these cells remain elusive. Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) expression has emerged as the main pathological signature of the encephalogenicity in both T and B cell compartment. In this review we have summarized the current data supporting GM-CSF relevance in MS pathophysiology, in the context of both immunomodulatory and neuroinflammatory processes; as well as the potential cellular sources of this stimulating factor, including different T and B cell subsets.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kostic M,Zivkovic N,Cvetanovic A,Stojanovic I

doi

10.1016/j.jneuroim.2018.07.002

subject

Has Abstract

pub_date

2018-10-15 00:00:00

pages

1-9

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30167-X

journal_volume

323

pub_type

杂志文章,评审

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