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Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus.

Abstract：

:The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa light chain mRNA-containing cells in brain and accumulation of virus-specific antibodies in cerebrospinal fluid. Treatment with BD-rat serum altered viral gene expression in persistently infected cultured rat glioblastoma cells. These data suggest that antibodies, produced in the brain, may influence viral gene expression.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hatalski CG,Hickey WF,Lipkin WI

doi

10.1016/s0165-5728(98)00066-6

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

128-36

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572898000666

journal_volume

90

pub_type

杂志文章

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