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Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes.

Abstract：

:We evaluated the concentration of antineuronal antibodies in paired cerebrospinal fluid (CSF) and serum samples from 19 patients with central and peripheral paraneoplastic neurological syndromes (PNS), using an enzyme linked immunosorbent assay (ELISA) employing recombinant antineuronal antigens (HuD, Yo, Ri, CV2/CRMP5, amphiphysin, PNMA2/Ma2). The specific antibody index (AI) [Qspec/QIgG] was calculated to estimate specific intrathecal antibody synthesis. An AI>1.3 was considered as evidence of intrathecal specific antibody synthesis. 14 (88%) of 16 patients with exclusive or predominant paraneoplastic involvement of the central nervous system (CNS) showed an AI>1.3, indicating a specific intrathecal antibody synthesis, while all three patients with isolated involvement of the peripheral nervous system showed an AI<0.8. All together, in 17 of 19 patients (89%) we found a significant association (p<0.05) between central or peripheral neurological manifestations on the one hand and presence or absence of specific intrathecal synthesis respectively on the other hand. These data support the hypothesis that autoimmunity is involved in the pathogenesis of PNS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Stich O,Jarius S,Kleer B,Rasiah C,Voltz R,Rauer S

doi

10.1016/j.jneuroim.2006.11.008

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

220-4

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00461-9

journal_volume

183

pub_type

杂志文章

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