当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice.

Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice.

Abstract：

:We showed previously that mice deficient in astrocyte gap junctions Cx43 and Cx30 exhibit white matter vacuolation and hypomyelination. In this study we tested the hypothesis that loss of astrocytic gap junction proteins leads to exacerbation of the primary demyelinating diseases, using experimental autoimmune encephalomyelitis (EAE) as a model system. To test for this, Cx43 floxed mice were crossed with GFAP:Cre, Cx30 null mice to generate mice lacking astrocytic expression of both Cx43 and Cx30 (dKO). EAE was induced using myelin oligodendrocyte glycoprotein (MOG(35-55)) peptide, and mice were monitored for acute expression of disease. No statistically significant difference in clinical or pathological expression of EAE was observed. Lesion load and susceptibility of different areas of the CNS to inflammation were similar in all genotypes. Moreover, no differences were noted in blood-brain barrier (BBB) permeability, tissue wet weight, axonal pathology, gliosis or demyelination during acute disease. These data show that loss of the astrocytic connexins, Cx43 and Cx30, and the white matter pathology observed in these mice does not statistically affect clinical or pathological expression of EAE and show that astrocyte gap junctions do not regulate autoimmune inflammation and associated BBB disruption in acute EAE.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Lutz SE,Raine CS,Brosnan CF

doi

10.1016/j.jneuroim.2012.01.007

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

8-14

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(12)00008-2

journal_volume

245

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain.

    abstract：:A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynaptic adrenergic sensitivity as well...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00244-7

    authors： Nickola TJ,Ignatowski TA,Spengler RN

    更新日期：2000-07-10 00:00:00

  • MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).

    abstract：:Recent studies suggest that monocyte activation may play a role in ALS pathogenesis. Therefore, monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), and plasma levels of MCP-1 were measured in 42 sALS patients, 38 healthy and 34 age-related macular degeneration (ARMD) controls. MCP-1 was elevate...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.06.008

    authors： Zhang R,Gascon R,Miller RG,Gelinas DF,Mass J,Lancero M,Narvaez A,McGrath MS

    更新日期：2006-10-01 00:00:00

  • Pattern recognition receptor mRNA expression and cytokine and granzyme levels in HIV infected individuals with neurotuberculosis.

    abstract：:Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRN...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.01.015

    authors： Rao D,Vasanthapuram R,Satishchandra P,Desai A

    更新日期：2018-05-15 00:00:00

  • Effect of rhTNF-alpha injection into rat sciatic nerve.

    abstract：:To assess whether TNF-alpha causes inflammatory demyelination or axonal degeneration, we injected into rat sciatic nerve saline, 100 U and 1000 U of rhTNF-alpha and studied the electrophysiological and pathological effects. At day 1 electrophysiology showed a slight reduction of proximal compound muscle action potenti...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00229-x

    authors： Uncini A,Di Muzio A,Di Guglielmo G,De Angelis MV,De Luca G,Lugaresi A,Gambi D

    更新日期：1999-02-01 00:00:00

  • Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis.

    abstract：:Resistance to experimental allergic encephalomyelitis (EAE) induction by homogenized myelin (MSCH) in complete Freund's adjuvant (CFA) and pertussigen (P) in SJL mice was seen 1 week after intravenous injection of PLP 139-151 coupled to spleen cells (PLP-ECDI-SP). Although this resistance could be transferred by splee...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(95)00022-t

    authors： Santambrogio L,Crisi GM,Leu J,Hochwald GM,Ryan T,Thorbecke GJ

    更新日期：1995-05-01 00:00:00

  • Caspase inhibitors protect against neuronal apoptosis induced by cerebrospinal fluid from multiple sclerosis patients.

    abstract：:Neuronal apoptosis has recently been implicated in multiple sclerosis (MS). Apoptotic cell death of neurons is induced in cultures exposed to cerebrospinal fluid (CSF) from MS patients. Since caspases are essential in the regulation of apoptosis, direct evidence was sought linking caspases to CSF-induced neuronal deat...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00467-8

    authors： Cid C,Alvarez-Cermeño JC,Regidor I,Plaza J,Salinas M,Alcázar A

    更新日期：2003-03-01 00:00:00

  • Characterization of naïve, memory and effector T cells in progressive multiple sclerosis.

    abstract：:We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all su...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.06.001

    authors： Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

    更新日期：2017-09-15 00:00:00

  • Targeting peptides for microglia identified via phage display.

    abstract：:Screening with a 7-mer phage display peptide library, a panel of cell-targeting peptides for the murine microglial cell line, EOC 20, was recognized. A number of similar, but not identical, sets of sequences representing more than 75% of all the cell line-binding clones were identified. Comparative analysis indicated ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00071-1

    authors： Samoylova TI,Ahmed BY,Vodyanoy V,Morrison NE,Samoylov AM,Globa LP,Baker HJ,Cox NR

    更新日期：2002-06-01 00:00:00

  • Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells.

    abstract：:Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.08.016

    authors： Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

    更新日期：2018-11-15 00:00:00

  • Alterations in cell-mediated immune response in subacute sclerosing panencephalitis.

    abstract：:To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we analyzed proliferation and cytokine secretion of cells from 35 patients and 42 healthy controls (HC) in response to central nervous system (CNS) antigens. The proliferation in response to myelin basic protein (MBP), myelin oligodendrocyt...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.09.002

    authors： Yentür SP,Gürses C,Demirbilek V,Yilmaz G,Onal AE,Yapici Z,Yalçinkaya C,Cokar O,Gökyiğit A,Saruhan-Direskeneli G

    更新日期：2005-12-30 00:00:00

  • Impaired immune responsiveness is an essential component in persistent central nervous system infection with gross murine leukemia virus.

    abstract：:Exposure of newborn mice to Gross murine leukemia virus (GMuLV) results in persistent viral infection of the central nervous system (CNS) white matter. Animals exposed to virus as neonates showed a marked depression in GMuLV-specific B lymphocyte function as evidenced by significant decreases in adult and neonatal ant...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90093-m

    authors： Korostoff JM,Nakada MT,Markman JF,Gaulton GN

    更新日期：1991-10-01 00:00:00

  • Elevated levels of the complement components C3 and factor B in ventricular cerebrospinal fluid of patients with traumatic brain injury.

    abstract：:Immunological events occurring in the central nervous system (CNS) as a result of head trauma are largely unexplored. We report here that the levels of the alternative pathway complement proteins C3 and factor B are elevated in the cerebrospinal fluid (CSF) of head-injured patients. C3 and factor B indices suggest tha...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00164-6

    authors： Kossmann T,Stahel PF,Morganti-Kossmann MC,Jones JL,Barnum SR

    更新日期：1997-03-01 00:00:00

  • Murine cytomegalovirus infection in mice results in an acute inflammatory reaction in peripheral nerves.

    abstract：:Human cytomegalovirus (CMV) infection is asymptomatic in immunocompetent individuals. However, it can lead to disease in immunodeficient population. Little is known of the mechanisms underlying the pathogenicity of the virus. We investigated the impact of CMV infection on mouse nervous system. Peripheral nerves but no...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.577017

    authors： Oladiran O,Yang M,Rivera VAG,Shi X,Huang J,Fournier S,Zhang J

    更新日期：2019-10-15 00:00:00

  • Features of skin-coincubated macrophages that promote recovery from spinal cord injury.

    abstract：:Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00260-1

    authors： Bomstein Y,Marder JB,Vitner K,Smirnov I,Lisaey G,Butovsky O,Fulga V,Yoles E

    更新日期：2003-09-01 00:00:00

  • The role of macrophages in demyelination.

    abstract：:Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS). In particular in the CsA-induced chronic relapsing form (CREAE), pronounced demyelination occurs, in temporal association with relapses. It is still a matter of discussion which cell type ultimately...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/0165-5728(92)90132-5

    authors： Dijkstra CD,De Groot CJ,Huitinga I

    更新日期：1992-10-01 00:00:00

  • Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function.

    abstract：:Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human pe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00253-4

    authors： Shibata A,Zelivyanskaya M,Limoges J,Carlson KA,Gorantla S,Branecki C,Bishu S,Xiong H,Gendelman HE

    更新日期：2003-09-01 00:00:00

  • Lack of m2 muscarinic acetylcholine receptor mRNA in rat lymphocytes.

    abstract：:The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype. In this study we analyzed th...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90187-2

    authors： Costa P,Castoldi AF,Traver DJ,Costa LG

    更新日期：1994-01-01 00:00:00

  • Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correla...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.08.012

    authors： Baranowska-Bik A,Kochanowski J,Uchman D,Wolinska-Witort E,Kalisz M,Martynska L,Baranowska B,Bik W

    更新日期：2013-10-15 00:00:00

  • Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.

    abstract：:Inflammation in the meninges, tissues surrounding the brain and spinal cord that enclose the cerebrospinal fluid, closely parallels clinical exacerbations in relapsing-remitting experimental autoimmune encephalomyelitis (EAE). In preclinical disease, an influx of innate immune cells precedes loss of blood brain barrie...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.12.009

    authors： Walker-Caulfield ME,Hatfield JK,Brown MA

    更新日期：2015-01-15 00:00:00

  • Tumour necrosis factor-alpha has few morphological effects within the dorsal columns of the spinal cord, in contrast to its effects in the peripheral nervous system.

    abstract：:There is circumstantial evidence implicating the pro-inflammatory cytokine tumour necrosis factor (TNF) in the pathogenesis of multiple sclerosis (MS), but there is no direct evidence that TNF can produce demyelination in the central nervous system (CNS). We demonstrate here that single injections of TNF into the dors...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00213-7

    authors： Hall SM,Redford EJ,Smith KJ

    更新日期：2000-07-01 00:00:00

  • Interactions between CD4+ T-cells and rat Schwann cells in vitro. 2. Cytotoxic effects of P2-specific CD4+ T-cell lines on Lewis rat Schwann cells.

    abstract：:The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with 51Cr-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not ne...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90209-4

    authors： Argall KG,Armati PJ,Pollard JD,Bonner J

    更新日期：1992-09-01 00:00:00

  • Circulating T-cell subsets in Guillain-Barré syndrome.

    abstract：:We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8+ (putative suppressor...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(85)80050-3

    authors： Lisak RP,Zweiman B,Guerrero F,Moskovitz AR

    更新日期：1985-05-01 00:00:00

  • Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

    abstract：:Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies that bind to P/Q voltage-gated calcium channels at the neuromuscular junction. Using cell-free direct peptide binding in 12 LEMS patients, we find linear B-cell epitopes that reside on the extracellular peptide linke...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00063-2

    authors： Parsons KT,Kwok WW

    更新日期：2002-05-01 00:00:00

  • Anti-GM1 IgA antibodies in Guillain-Barré syndrome.

    abstract：:Serum anti-GM1 IgA antibodies were detected in 15 of 53 (28%) patients with the acute Guillain-Barré syndrome (GBS) and in one of 26 (4%) patients with other neurological diseases. Although nine GBS patients had anti-GM1 IgA titers of 1:200 or less, six patients had titers of 1:800 or more. Some GBS patients with anti...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90031-f

    authors： Ilyas AA,Mithen FA,Chen ZW,Cook SD

    更新日期：1992-01-01 00:00:00

  • Production and characterization of high titer antibodies to galactocerebroside.

    abstract：:High titer antibodies primarily of the IgG class were produced against galactocerebroside (GalC) by including keyhole limpet hemocyanin (KLH) and supplemental M. tuberculosis in the adjuvant mixture used for immunization of rabbits. Antibody titers were determined by an ELISA in which microtiter wells were coated with...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(87)90019-1

    authors： Benjamins JA,Callahan RE,Montgomery IN,Studzinski DM,Dyer CA

    更新日期：1987-04-01 00:00:00

  • "Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions".

    abstract：:Allograft inflammatory factor-1 (AIF-1) is a 17-kDa-peptide identified in rat cardiac allografts undergoing chronic rejection and in activated microglial cells in inflammatory autoimune disease of the CNS. We have investigated the expression of AIF-1 in 18 autopsy cases of human focal cerebral infarction. AIF-1-positi...

    journal_title：Journal of neuroimmunology

    pub_type： 更正并重新发布的文章,杂志文章

    doi：10.1016/s0165-5728(00)00283-6

    authors： Postler E,Rimner A,Beschorner R,Schluesener HJ,Meyermann R

    更新日期：2000-08-01 00:00:00

  • CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis.

    abstract：:We simultaneously measured 16 cytokines/chemokines in cerebrospinal fluid (CSF) from 14 patients with acute disseminated encephalomyelitis (ADEM) and 20 controls using a fluorescent bead-based immunoassay. A variety of cytokines, such as IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-gamma, TNF-alpha, G-CSF and MI...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.03.020

    authors： Ishizu T,Minohara M,Ichiyama T,Kira R,Tanaka M,Osoegawa M,Hara T,Furukawa S,Kira J

    更新日期：2006-06-01 00:00:00

  • Cyclophosphamide alters the clinical and pathological expression of experimental autoimmune gray matter disease.

    abstract：:Guinea pigs inoculated with bovine spinal cord ventral horn homogenate develop a syndrome termed experimental autoimmune gray matter disease (EAGMD) characterized by extremity weakness, bulbar signs, and a loss of lower and upper motoneurons. To provide evidence for the role of autoimmune mechanisms, we have administe...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90123-o

    authors： Tajti J,Stefani E,Appel SH

    更新日期：1991-11-01 00:00:00

  • Serum CD95 of relapsing remitting multiple sclerosis patients protects from CD95-mediated apoptosis.

    abstract：:Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease. Here, we report that the sera of MS patien...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00032-0

    authors： Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

    更新日期：1998-06-15 00:00:00

  • Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica.

    abstract：:Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.05.007

    authors： Akaishi T,Nakashima I,Misu T,Fujihara K,Aoki M

    更新日期：2015-06-15 00:00:00