Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function.

abstract：:A high proportion of peptide 1-11 specific T cells from H-2u (V beta 8+, H-2u) mice express the V beta 8 TCR chain. Peptide 89-101 is immunodominant for B10.RIII (V beta 8+, H-2r) mice; thus, it was of interest to determine whether V beta 8 TCR would be over-represented in a population of peptide 89-101-specific T cel...

journal_title：Journal of neuroimmunology

authors： Zhao ML,Xia JQ,Fritz RB

更新日期：1993-02-01 00:00:00

abstract：:Early diagnosis of multiple sclerosis (MS) may be assisted by tests for the abnormal immune responses of the central nervous system (CNS) including oligoclonal IgG bands in the cerebrospinal fluid (CSF), increased CNS IgG synthesis, increased CNS antibody synthesis against multiple viruses and increased numbers of enl...

journal_title：Journal of neuroimmunology

authors： Iivanainen MV

更新日期：1981-06-01 00:00:00

abstract：:We evaluated the presence of soluble (s) CD4 and sCD8, released from activated T cells, in the sera of patients with multiple sclerosis (MS) and human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). In addition, peripheral blood T cell subsets in pat...

journal_title：Journal of neuroimmunology

authors： Tsukada N,Matsuda M,Miyagi K,Yanagisawa N

更新日期：1991-12-01 00:00:00

abstract：:Autoantibodies which bind to integral membrane proteins of brain were tested for their ability to bind to cross-reactive antigens on non-neural tissue. Both brain specific autoantibodies and antibodies which bind to cross-reactive antigens were found. There were two types of brain reactive autoantibodies which could n...

journal_title：Journal of neuroimmunology

authors： Hoffman SA,Madsen CS

更新日期：1990-12-01 00:00:00

abstract：:Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system. Caveolin-3 is needed for muscle repair and skeletal muscle development. The objective of this study was to compare caveolin-3 expression in myasthenia gravis (MG) and control muscles. Caveolin-3 was abnormally expres...

journal_title：Journal of neuroimmunology

authors： Iwasa K,Furukawa Y,Yoshikawa H,Yamada M

更新日期：2016-12-15 00:00:00

abstract：:Using the alpha(181-192) peptides of neuronal nicotinic acetylcholine receptor (nAChR) and Ala-substituted peptide analogues, amino acid residues critical for specific monoclonal antibody (mAb) binding were identified. By means of 2D nuclear magnetic resonance (2D-NMR) analysis followed by molecular modeling, it was f...

journal_title：Journal of neuroimmunology

authors： Skok M,Lykhmus E,Bobrovnik S,Tzartos S,Tsouloufis T,Vanderesse R,Coutrot F,Thong Cung M,Marraud M,Krikorian D,Sakarellos-Daitsiotis M

更新日期：2001-12-03 00:00:00

abstract：:Following inflammation or infection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence th...

journal_title：Journal of neuroimmunology

authors： Guyon A,Massa F,Rovère C,Nahon JL

更新日期：2008-07-31 00:00:00

abstract：:Over the past decade, remarkable progress has been made in our understanding of the pathogenesis of Miller Fisher syndrome (MFS), a clinical variant of Guillain Barré syndrome (GBS). MFS comprises the clinical triad of ataxia, areflexia and ophthalmoplegia. It is associated with acute-phase IgG antibodies to GQ1b and ...

journal_title：Journal of neuroimmunology

authors： Willison HJ,O'Hanlon GM

更新日期：1999-12-01 00:00:00

abstract：:Autologous stem cell transplantation is being considered as treatment of severe refractory autoimmune disorders, including MS. Stem cell mobilization is achieved with granulocyte-colony stimulating factor (G-CSF), however, G-CSF administration resulted in cases of worsened clinical MS status. We studied autoreactive T...

journal_title：Journal of neuroimmunology

authors： Snir O,Lavie G,Achiron A,Bank I,Ben-Aharon T,Sredni B,Cohen IR,Mandel M

更新日期：2006-03-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB) induces both cellular immunosuppression and an inflammatory response. In an effort to better characterize CPB-induced immune dysfunction, we examined the chemotaxic ability of human granulocytes and macrophages to D-Ala2-Met-enkephalin (DAME) and interleukin (IL)-1 alpha with computer-assi...

journal_title：Journal of neuroimmunology

authors： Stefano GB,Bilfinger TV

更新日期：1993-09-01 00:00:00

abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

journal_title：Journal of neuroimmunology

authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

更新日期：2016-01-15 00:00:00

abstract：:The plasma from eight patients with multiple sclerosis (MS) whose disease was in remission, was investigated by a chemiluminescence technique for its ability to stimulate the oxidative metabolism of peripheral blood monocytes (PBM). The active fraction identified had a molecular weight between 13,700 and 43,000 Da. It...

journal_title：Journal of neuroimmunology

authors： Hammann KP,Hopf HC

更新日期：1986-11-01 00:00:00

abstract：:Stroke may be accompanied by immunological consequences including local autoimmunity and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the immune system gain direct access to the brain parenchyma. Here local autoimmunity contributes to lesion formation and, in experimental stroke, ...

journal_title：Journal of neuroimmunology

authors： Vogelgesang A,Dressel A

更新日期：2011-02-01 00:00:00

abstract：:Interleukin (IL)-10 is an anti-inflammatory cytokine that can down-regulate various aspects of the immune response. In this study we demonstrate that exposure to a psychophysiological stressor (swim stress) increases IL-10 production in female rats in response to an in vivo challenge with bacterial lipopolysaccharide ...

journal_title：Journal of neuroimmunology

authors： Connor TJ,Brewer C,Kelly JP,Harkin A

更新日期：2005-02-01 00:00:00

abstract：:Eleven dogs were experimentally infected with canine distemper virus and studied for periods of up to 63 days post-inoculation. The responsiveness of lymphocytes in vitro toward phytohemagglutinin, myelin basic protein and galactocerebroside was tested at regular intervals during the course of infection by means of [3...

journal_title：Journal of neuroimmunology

authors： Cerruti-Sola S,Kristensen F,Vandevelde M,Bichsel P,Kihm U

更新日期：1983-04-01 00:00:00

abstract：:HIV-1 expression in monocytes/macrophages can be controlled by transforming growth factor-beta 1 (TGF-beta 1). TGF-beta 1 is present in astrocytes surrounding HIV-1-infected monocyte/macrophages in brain tissue from patients with AIDS but not from seronegative, normal individuals. We sought to determine whether or not...

journal_title：Journal of neuroimmunology

authors： da Cunha A,Jackson RW,Vitković L

更新日期：1995-07-01 00:00:00

abstract：:Experimental autoimmune myasthenia gravis (EAMG), which to some extent represents an experimental counterpart of human myasthenia gravis, can be induced by inoculation of various animal species and strains with acetylcholine receptor (AChR). The oral administration of Torpedo AChR to Lewis rats prior to immunization w...

journal_title：Journal of neuroimmunology

authors： Wang ZY,Qiao J,Link H

更新日期：1993-05-01 00:00:00

abstract：:Transcriptional dysregulation is a major pathological feature of Huntington's disease (HD). The goal of this study was to understand how p65/RelA co-regulated genes, specifically those of the cytokine and endocannabinoid systems, were affected in HD. p65/RelA levels were lower in human HD tissue and R6/2 HD mice, as w...

journal_title：Journal of neuroimmunology

authors： Laprairie RB,Warford JR,Hutchings S,Robertson GS,Kelly ME,Denovan-Wright EM

更新日期：2014-02-15 00:00:00

abstract：:In 1996, we reported the results of a linkage genome screen based on 129 UK multiple sclerosis multiplex families, together with follow-up typing of interesting regions in a second set of families. We have now completed screening the remainder of the genome in this second set of United Kingdom families by typing 242 m...

journal_title：Journal of neuroimmunology

authors： Hensiek AE,Roxburgh R,Smilie B,Coraddu F,Akesson E,Holmans P,Sawcer SJ,Compston DA

更新日期：2003-10-01 00:00:00

abstract：:A monoclonal antibody, designated C138, was raised against a particulate fraction from young postnatal mouse cerebellum. In sections from adult mouse brain and cerebellum, this antibody stained a sub-population of neurons. Cell bodies of large neurones and fibre tracts were negative in all brain regions examined, wher...

journal_title：Journal of neuroimmunology

authors： Hirsch MR,Langley OK,Ghandour MS,Hirn M,Gombos G,Goridis C

更新日期：1983-06-01 00:00:00

abstract：:The surface receptors involved in natural killer (NK) cell triggering during the process of target cell lysis have been at least in part identified. These are members of a novel family of receptors that has been termed natural cytotoxicity receptors (NCR). The first three members of this emerging group of receptors ar...

journal_title：Journal of neuroimmunology

authors： Sivori S,Parolini S,Marcenaro E,Castriconi R,Pende D,Millo R,Moretta A

更新日期：2000-07-24 00:00:00

abstract：:EAN induced in Lewis rats by immunization with peripheral bovine myelin was treated by the Ras inhibitor farnesylthiosalicylate (FTS). Treatment from day 0 with FTS (5 mg/kg intraperitoneally twice daily) attenuated peak clinical scores (mean+/-S.E., 2.5+/-0.5 compared to 4.1+/-0.5 in saline treated controls, p=0.018,...

journal_title：Journal of neuroimmunology

authors： Kafri M,Kloog Y,Korczyn AD,Ferdman-Aronovich R,Drory V,Katzav A,Wirguin I,Chapman J

更新日期：2005-11-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to G...

journal_title：Journal of neuroimmunology

authors： Jayasimhan A,Ellis DP,Ziegler AI,Slattery RM

更新日期：2019-02-15 00:00:00

abstract：:A monoclonal antibody (7.1B3) has been produced in mice previously immunised with a glycoprotein fraction prepared from human myotube cells grown in tissue culture. The antibody precipitates an antigen complex of four glycoprotein components from detergent extracted human muscle myotube cultures. These are two chains ...

journal_title：Journal of neuroimmunology

authors： Walsh FS,Phillips E,Dhut S,Moore SE

更新日期：1983-08-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an inflammatory autoimmune demyelinating disease of the peripheral nervous system (PNS) and represents an animal model of Guillain-Barré syndrome (GBS), which is a major inflammatory demyelinating disease of the PNS in humans. In the present study, the dynamics of the expressi...

journal_title：Journal of neuroimmunology

authors： Zou LP,Pelidou SH,Abbas N,Deretzi G,Mix E,Schaltzbeerg M,Winblad B,Zhu J

更新日期：1999-08-03 00:00:00

abstract：:The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone l...

journal_title：Journal of neuroimmunology

authors： Paciotti GF,Skwerer RG,Tamarkin L

更新日期：1987-10-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

journal_title：Journal of neuroimmunology

authors： Conrady CD,Drevets DA,Carr DJ

更新日期：2010-03-30 00:00:00

abstract：:HIV-associated cognitive neurological disorders (HAND) prevail in the antiretroviral therapy era. Proteomics analysis of CSF revealed expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) in Hispanic women with cognitive impairment (CI). We tested the hypothesis that there is reduced capacity of antioxidant enzymes in ...

journal_title：Journal of neuroimmunology

authors： Velázquez I,Plaud M,Wojna V,Skolasky R,Laspiur JP,Meléndez LM

更新日期：2009-01-03 00:00:00

abstract：:Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

journal_title：Journal of neuroimmunology

authors： Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

更新日期：2002-06-01 00:00:00

abstract：:This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less s...

journal_title：Journal of neuroimmunology

authors： Aharoni R,Aricha R,Eilam R,From I,Mizrahi K,Arnon R,Souroujon MC,Fuchs S

更新日期：2013-09-15 00:00:00