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Inhibition of Ras attenuates the course of experimental autoimmune neuritis.

Abstract：

:EAN induced in Lewis rats by immunization with peripheral bovine myelin was treated by the Ras inhibitor farnesylthiosalicylate (FTS). Treatment from day 0 with FTS (5 mg/kg intraperitoneally twice daily) attenuated peak clinical scores (mean+/-S.E., 2.5+/-0.5 compared to 4.1+/-0.5 in saline treated controls, p=0.018, t-test) but not recovery. Treatment from day 10 with FTS attenuated peak disability (2.5+/-0.6, p=0.032 compared to saline treated controls) and improved recovery (0.84+/-0.42, untreated controls 2.4+/-0.6, p=0.028 by repeated measures ANOVA). Effects were confirmed by rotarod and nerve conduction studies. An inactive analogue, geranylthiosalicylate, had no clinical effect. Inhibition of Ras is of potential use in the treatment of inflammatory neuropathies.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kafri M,Kloog Y,Korczyn AD,Ferdman-Aronovich R,Drory V,Katzav A,Wirguin I,Chapman J

doi

10.1016/j.jneuroim.2005.07.008

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

46-55

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00307-3

journal_volume

168

pub_type

杂志文章

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