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Normal human plasma contains antibodies that specifically block neuropathy-associated human anti-GM1 IgG-antibodies.

Abstract：

:Intravenous immunoglobulin (IVIg) is used in the treatment of a variety of autoimmune diseases. The blocking of disease-associated antibodies by anti-idiotype antibodies present in IVIg has been proposed as an action mechanism. Anti-GM1 antibodies have been implicated in motor neuropathies. Although IVIg is frequently applied for these diseases, the presence in IVIg or in human plasma of anti-idiotype antibodies that recognize anti-GM1 antibodies has not been clearly demonstrated. Here we present evidence that normal human plasma contains antibodies that inhibit the binding of anti-GM1 IgG-antibodies from neuropathy patients but do not inhibit anti-GM1 IgG-antibodies of rabbit origin with the same fine specificity. The significance of these findings in the course of acute and chronic neuropathies is discussed.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Lopez PH,Irazoqui FJ,Nores GA

doi

10.1016/s0165-5728(99)00276-3

subject

Has Abstract

pub_date

2000-06-26 00:00:00

pages

179-83

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572899002763

journal_volume

105

pub_type

杂志文章

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